Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Nadine U. Strempel"'
Autor:
Stephanie Plassmann, Juan Manuel Ramírez-Anguita, Annett Boeddrich, Elsa Sanchez-Garcia, Jana Wolf, Erich E. Wanker, Kenny Bravo-Rodriguez, Nadine U. Strempel, Antonio Z. Politi, Anne Ast, Konrad Klockmeier, Katharina Baum, Alexander Buntru, Anne S. Wagner, Christian Haenig, Lydia Brusendorf
Huntingtin (HTT) fragments with extended polyglutamine (polyQ) tracts self-assemble into amyloid-like fibrillar aggregates. Elucidating the fibril formation mechanism is critical for understanding Huntington’s disease pathology and for developing n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72958ae99f7a7d477ada0313341725a6
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85045543107
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85045543107
Publikováno v:
Essays in Biochemistry. 56:167-180
PolyQ (polyglutamine) diseases such as HD (Huntington's disease) or SCA1 (spinocerebellar ataxia type 1) are neurodegenerative disorders caused by abnormally elongated polyQ tracts in human proteins. PolyQ expansions promote misfolding and aggregatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e3de85a7bdb080ee0730dc4298aca18
https://doi.org/10.1042/bse0560167
https://doi.org/10.1042/bse0560167
Autor:
Yacine Bounab, Gillian P. Bates, Ralf P. Friedrich, David Fournier, Josef Priller, Miguel A. Andrade-Navarro, Konrad Klockmeier, Christian Haenig, Matthias E. Futschik, Franziska Hesse, Sean Patrick Riechers, Erich E. Wanker, Stephan J. Sigrist, Sargon Yigit, Martin Stroedicke, Nadine U. Strempel, Michael R. Hayden, Rona K. Graham, Sigrid Schnoegl, Annett Boeddrich, Shuang Li, Jenny Russ, Thomas Wiglenda, Cecilia Nicoletti, Gautam Chaurasia
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Assemblies of huntingtin (HTT) fragments with expanded polyglutamine (polyQ) tracts are a pathological hallmark of Huntington's disease (HD). The molecular mechanisms by which these structures are formed and cause neuronal dysfunction and toxicity ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11b6410b3bf5fa81355c1008e6a41ee2
https://hdl.handle.net/10400.1/11700
https://hdl.handle.net/10400.1/11700