Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Nadine Reischmann"'
Autor:
Manon A Simard, Carlos Cabrera-Galvez, Santiago Viteri, Felix Geist, Nadine Reischmann, Michael Zühlsdorf, Niki Karachaliou
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 57, Iss , Pp 101063- (2024)
MET inhibitors have demonstrated efficacy in treating patients with non-small cell lung cancer (NSCLC) harboring METex14 skipping alterations. Advancements in spatial profiling technologies have unveiled the complex dynamics of the tumor microenviron
Externí odkaz:
https://doaj.org/article/3bf51d62f03b48e4a51b131b02e0e59d
Autor:
Nadine Reischmann, Carolin Schmelas, Miguel Ángel Molina-Vila, Núria Jordana-Ariza, Daniel Kuntze, Silvia García-Roman, Manon A. Simard, Doreen Musch, Christina Esdar, Joachim Albers, Niki Karachaliou
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107006- (2023)
Summary: This study evaluates the efficacy of combining targeted therapies with MET or SHP2 inhibitors to overcome MET-mediated resistance in different NSCLC subtypes. A prevalence study was conducted for MET amplification and overexpression in sampl
Externí odkaz:
https://doaj.org/article/212794a83ace4b01a781beca9b628143
A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts
Autor:
Max Nobis, David Herrmann, Sean C. Warren, Shereen Kadir, Wilfred Leung, Monica Killen, Astrid Magenau, David Stevenson, Morghan C. Lucas, Nadine Reischmann, Claire Vennin, James R.W. Conway, Alice Boulghourjian, Anaiis Zaratzian, Andrew M. Law, David Gallego-Ortega, Christopher J. Ormandy, Stacey N. Walters, Shane T. Grey, Jacqueline Bailey, Tatyana Chtanova, Julian M.W. Quinn, Paul A. Baldock, Peter I. Croucher, Juliane P. Schwarz, Agata Mrowinska, Lei Zhang, Herbert Herzog, Andrius Masedunskas, Edna C. Hardeman, Peter W. Gunning, Gonzalo del Monte-Nieto, Richard P. Harvey, Michael S. Samuel, Marina Pajic, Ewan J. McGhee, Anna-Karin E. Johnsson, Owen J. Sansom, Heidi C.E. Welch, Jennifer P. Morton, Douglas Strathdee, Kurt I. Anderson, Paul Timpson
Publikováno v:
Cell Reports, Vol 21, Iss 1, Pp 274-288 (2017)
The small GTPase RhoA is involved in a variety of fundamental processes in normal tissue. Spatiotemporal control of RhoA is thought to govern mechanosensing, growth, and motility of cells, while its deregulation is associated with disease development
Externí odkaz:
https://doaj.org/article/c83a8ae4b29e4df59cdaacb8bc5a5802
Autor:
Florian Weinberg, Nadine Reischmann, Lisa Fauth, Sanaz Taromi, Justin Mastroianni, Martin Köhler, Sebastian Halbach, Andrea C. Becker, Niantao Deng, Tatjana Schmitz, Franziska Maria Uhl, Nicola Herbener, Bianca Riedel, Fabian Beier, Alexander Swarbrick, Silke Lassmann, Jörn Dengjel, Robert Zeiser, Tilman Brummer
Publikováno v:
EBioMedicine, Vol 20, Iss C, Pp 79-97 (2017)
Despite being overexpressed in different tumor entities, RIO kinases are hardly characterized in mammalian cells. We investigated the role of these atypical kinases in different cancer cells. Using isogenic colon-, breast- and lung cancer cell lines,
Externí odkaz:
https://doaj.org/article/32fd6546823d4e5fa47b9bb4b923d4d0
Autor:
Zahra Erami, David Herrmann, Sean C. Warren, Max Nobis, Ewan J. McGhee, Morghan C. Lucas, Wilfred Leung, Nadine Reischmann, Agata Mrowinska, Juliane P. Schwarz, Shereen Kadir, James R.W. Conway, Claire Vennin, Saadia A. Karim, Andrew D. Campbell, David Gallego-Ortega, Astrid Magenau, Kendelle J. Murphy, Rachel A. Ridgway, Andrew M. Law, Stacey N. Walters, Shane T. Grey, David R. Croucher, Lei Zhang, Herbert Herzog, Edna C. Hardeman, Peter W. Gunning, Christopher J. Ormandy, T.R. Jeffry Evans, Douglas Strathdee, Owen J. Sansom, Jennifer P. Morton, Kurt I. Anderson, Paul Timpson
Publikováno v:
Cell Reports, Vol 14, Iss 1, Pp 152-167 (2016)
E-cadherin-mediated cell-cell junctions play a prominent role in maintaining the epithelial architecture. The disruption or deregulation of these adhesions in cancer can lead to the collapse of tumor epithelia that precedes invasion and subsequent me
Externí odkaz:
https://doaj.org/article/df26cad288c04a3b996446d05fb3fd9a
Autor:
Melanie Boerries, Nadine Reischmann, Thomas Reinheckel, Tilman Brummer, Geoffroy Andrieux, Ricarda Griffin
Publikováno v:
Oncogene
BRAFV600E confers poor prognosis and is associated with a distinct subtype of colorectal cancer (CRC). Little is known, however, about the genetic events driving the initiation and progression of BRAFV600E mutant CRCs. Recent genetic analyses of CRCs
Autor:
Franziska M. Uhl, Ulrike Burk, Shuofei Cheng, Sandra Braun, Sebastian Halbach, Tilman Brummer, Manuel Lauinger, Thomas Reinheckel, Nadine Reischmann, Martin Köhler, Sophia Ehrenfeld, Kathrin Ringwald, Robert Zeiser, Natalie Köhler, Christoph Peters, Corinna Spohr
Publikováno v:
Oncogene. 38:1324-1339
Copy number gains, point mutations and epigenetic silencing events are increasingly observed in genes encoding elements of the Ras/Raf/MEK/ERK signaling axis in human breast cancer. The three Raf kinases A-Raf, B-Raf, and Raf-1 have an important role
Autor:
Nadine Reischmann, Lorenz Pudelko, Christopher Stroh, Nina Linde, Doreen Musch, Marina Keil, Linda Pudelko, Christina Esdar, Andree Blaukat, Karl M. Schumacher, Niki Karachaliou
Publikováno v:
Cancer Research. 82:1105-1105
Background: Although advancements have been made in available targeted therapies for non-small cell lung cancer (NSCLC), most patients have an incomplete response and eventually acquire resistance. It is well known that MET signaling is a key pathway
Autor:
Núria Jordana-Ariza, Nadine Reischmann, Carlos Esparré, Ruth Román, Cristina Aguado-Esteban, Silvia García-Román, Christopher Stroh, Andrés Aguilar Aguilar, Rafael Rosell, Niki Karachaliou, Miguel A. Molina-Vila
Publikováno v:
Cancer Research. 82:1106-1106
Background: ALK and ROS1 fusion-positive NSCLC patients derive clinical benefit from tyrosine kinase inhibitors (TKIs) but ultimately relapse. Acquired resistance mechanisms include on-target secondary mutations or copy number gains and activation of
Autor:
Natalie Köhler, Johana Norona, Tatjana Zabelina, Melanie Boerries, Bruce R. Blazar, Till S. Clauditz, Michele Proietti, Bodo Grimbacher, Annette Schmitt-Graeff, Steffen Heeg, Geoffroy Andrieux, Nadine Reischmann, Nicolaus Kroeger, Gregory A. Taylor, Dietmar Pfeifer, Robert Zeiser, Ian J. Frew, Alla Bulashevska, Jocelyn de Heer, Antonella Catalano, Ami S. Bhatt, Tilman Brummer, Dominik Schmidt, Rebekka Ihlemann, Francis Ayuk, Benjamin A. Siranosian, Petya Apostolova
Publikováno v:
Blood
Acute graft-versus-host disease (GVHD) is a life-threatening complication after allogeneic hematopoietic cell transplantation (allo-HCT). Although currently used GVHD treatment regimens target the donor immune system, we explored here an approach tha