Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Nadine Pavloff"'
Autor:
Ben Cadieux, Nadine Pavloff, Sara Louis Isbell, Terry A Hauser, Christopher S. Williams, Mark Johnson
Publikováno v:
Drug Design, Development and Therapy. 12:2795-2804
Nadine Pavloff,1 Terry A Hauser,1 Chris Williams,2 Sara Louis Isbell,1 Ben Cadieux,1 Mark Johnson1 1Horizon Pharma,Inc., Lake Forest, IL, USA; 2Alcami Corporation, Wilmington, NC, USA Background: Cysteamine bitartrate delayed-release (DR) capsule (Pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b1dcba52010f5997b6bdb5b38314bf5
https://doi.org/10.2147/dddt.s174928
https://doi.org/10.2147/dddt.s174928
Autor:
Beth Levy, Carole Vogler, Emil D. Kakkis, Nancy Galvin, William S. Sly, Nadine Pavloff, Jeffrey H. Grubb, Yun Tan
Publikováno v:
Proceedings of the National Academy of Sciences. 102:14777-14782
Enzyme replacement therapy (ERT) effectively reverses storage in several lysosomal storage diseases. However, improvement in brain is limited by the blood-brain barrier except in the newborn period. In this study, we asked whether this barrier could
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b541a99ca6f0e7c9b4f0daf24a521415
https://doi.org/10.1073/pnas.0506892102
https://doi.org/10.1073/pnas.0506892102
Autor:
Michel C. Vellard, Todd C. Zankel, Vishwanath Koppaka, Guojun Bu, Jeff F. Lemontt, Allora I. Aguilera, Minmin Qin, Keri L. Schwartz, Dan J Wendt, Paul A. Fitzpatrick, Terri Christianson, Lynn M. McCormick, William S. Prince, Nadine Pavloff, Chris M. Starr
Publikováno v:
Journal of Biological Chemistry. 279:35037-35046
Enzyme replacement therapy for lysosomal storage disorders depends on efficient uptake of recombinant enzyme into the tissues of patients. This uptake is mediated by oligosaccharide receptors including the cation-independent mannose 6-phosphate recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c68cc05d6c6650a2623091834156f378
https://doi.org/10.1074/jbc.m402630200
https://doi.org/10.1074/jbc.m402630200
Autor:
Vaclav Prochazka, Philip A. Pemberton, Nadine Pavloff, Jan Potempa, Philip J. Barr, Wan Ching Audrey Chen, James Travis, Robert N. Pike, Michael C. Kiefer
Publikováno v:
Journal of Biological Chemistry. 272:1595-1600
The proteinases of Porphyromonas gingivalis are key virulence factors in the etiology and progression of periodontal disease. Previous work in our laboratories resulted in the purification of arginine- and lysine-specific cysteine proteinases, design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::914e65933818cc771b0ed7d496ca65f4
https://doi.org/10.1074/jbc.272.3.1595
https://doi.org/10.1074/jbc.272.3.1595
Publikováno v:
Trends in Microbiology. 3:430-434
Analysis of the available data on the Porphyromonas gingivalis proteinase system suggests that at most three different genes encode arginine-X- and lysine-X-specific cysteine proteinases. These are synthesized as polyproteins containing a prepropepti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0894b7fe72d2249e9aba0c5fe7ebf4f
https://doi.org/10.1016/s0966-842x(00)88996-9
https://doi.org/10.1016/s0966-842x(00)88996-9
Autor:
Michael C. Kiefer, Nadine Pavloff, Vaclav Prochazka, Philip J. Barr, Robert N. Pike, James Travis, Jan Potempa
Publikováno v:
Journal of Biological Chemistry. 270:1007-1010
The identification of proteinases of Porphyromonas gingivalis that act as virulence factors in periodontal disease has important implications in the study of host-pathogen interactions as well as in the discovery of potential therapeutic and immunopr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1825f58c6e1cbe4a84f2789527a260b5
https://doi.org/10.1074/jbc.270.3.1007
https://doi.org/10.1074/jbc.270.3.1007
Publikováno v:
DNA Sequence. 2:227-234
We have isolated and sequenced overlapping cDNA clones from a breast carcinoma cDNA library containing the entire coding region of both the R1 and R2 subunits of the human ribonucleotide reductase gene. The coding region of the human R1 subunit compr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f8f43b1ca90b4cb3ea2864abe392b96
https://doi.org/10.3109/10425179209020807
https://doi.org/10.3109/10425179209020807
Autor:
James R. Erickson, Zahi M. Mouchabeck, A. Rene Tipton, Michael C. Kiefer, Philip A. Pemberton, Jason Smith, Nadine Pavloff
Publikováno v:
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 45(12)
The tumor suppressor maspin (mammary serpin) was originally identified as a component of human mammary epithelial cells that is downregulated as mammary tumor cells progress from the benign to the invasive and metastatic states. Maspin inhibits cellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f7f1b2f2392c7eb73d7a83da53dd26c
https://pubmed.ncbi.nlm.nih.gov/9389773
https://pubmed.ncbi.nlm.nih.gov/9389773
Publikováno v:
Biochemical and Biophysical Research Communications. 163:1128-1134
Burkitt lymphoma cells and their counterpart of normal origin contain proteins with associated tyrosine protein, kinase activity. These proteins were isolated by affinity chromatography and Fast Pressure Liquid Chromatography. Proteins with enzyme ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::179286118e5c730eeb7ca25b98c990ec
https://doi.org/10.1016/0006-291x(89)92338-3
https://doi.org/10.1016/0006-291x(89)92338-3
Publikováno v:
Biochemical and Biophysical Research Communications. 121:779-787
A protein kinase activity (PK) was associated with immunoprecipitates between polypeptides of human lymphoblastoid cells of malignant origin (Raji cell line) or of their normal counterparts (Priess cell line) and antibodies directed against avian pp6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3522112d703bcf726a4a8f28c39f3ae
https://doi.org/10.1016/0006-291x(84)90746-0
https://doi.org/10.1016/0006-291x(84)90746-0