Diagnostic biomarkers for adult haemophagocytic lymphohistiocytosis in critically ill patients (HEMICU): a prospective observational study protocol

Autor: Claudia Spies, Gunnar Lachmann, Cornelia Knaak, Clarissa von Haefen, Nadine Paeschke, Christian Meisel, Peter Nyvlt, Friederike S Schuster, Sophie K Piper, Jochen Kruppa, Gerald Vorderwülbecke, Felix Balzer, Paul La Rosée, Thomas Schenk, Nadine Unterwalder, Uwe Kölsch, Nils Lachmann, Levent Akyüz, Frank M Brunkhorst, Hans-Dieter Volk, Didier Keh

Publikováno v: BMJ Open, Vol 9, Iss 10 (2019)

Introduction Haemophagocytic lymphohistiocytosis (HLH) in adults is characterised by toxic immune activation and a sepsis-like syndrome, leading to high numbers of undiagnosed cases and mortality rates of up to 68%. Early diagnosis and specific immun

Externí odkaz: https://doaj.org/article/96907cc990d04601bb78e19a14d23c1d

Acetylcholinesterase inhibitors reduce neuroinflammation and -degeneration in the cortex and hippocampus of a surgery stress rat model.

Autor: Alexander Kalb, Clarissa von Haefen, Marco Sifringer, Annalena Tegethoff, Nadine Paeschke, Mariya Kostova, Aarne Feldheiser, Claudia D Spies

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e62679 (2013)

Exogenous stress like tissue damage and pathogen invasion during surgical trauma could lead to a peripheral inflammatory response and induce neuroinflammation, which can result in postoperative cognitive dysfunction (POCD). The cholinergic anti-infla

Externí odkaz: https://doaj.org/article/688f3a89cbfc44649dc67ec1cc3cf5e2

Dexmedetomidine Prevents Lipopolysaccharide-Induced MicroRNA Expression in the Adult Rat Brain

Autor: Claudia Spies, Stefanie Endesfelder, Marco Sifringer, Nadine Paeschke, Clarissa von Haefen

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 18, Iss 9, p 1830 (2017)
International Journal of Molecular Sciences; Volume 18; Issue 9; Pages: 1830

During surgery or infection, peripheral inflammation can lead to neuroinflammation, which is associated with cognitive impairment, neurodegeneration, and several neurodegenerative diseases. Dexmedetomidine, an α-2-adrenoceptor agonist, is known to e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::778a60038bca004b8fe79ac8e4b39022
http://europepmc.org/articles/PMC5618479

Acetylcholinesterase inhibitors reduce neuroinflammation and -degeneration in the cortex and hippocampus of a surgery stress rat model

Autor: Marco Sifringer, Claudia Spies, Aarne Feldheiser, Nadine Paeschke, Clarissa von Haefen, Annalena Tegethoff, Alexander Kalb, Mariya Kostova

Publikováno v: PLoS ONE
PLoS ONE, Vol 8, Iss 5, p e62679 (2013)

Exogenous stress like tissue damage and pathogen invasion during surgical trauma could lead to a peripheral inflammatory response and induce neuroinflammation, which can result in postoperative cognitive dysfunction (POCD). The cholinergic anti-infla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a8a45ab160e6c61aef4440d9261f6c2
https://pubmed.ncbi.nlm.nih.gov/23671623