Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Nadine M. Aziz"'
Autor:
Nadine M. Aziz, Jenny A. Klein, Morgan R. Brady, Jose Luis Olmos-Serrano, Vittorio Gallo, Tarik F. Haydar
Publikováno v:
Journal of Neurodevelopmental Disorders, Vol 11, Iss 1, Pp 1-17 (2019)
Abstract Background Down syndrome (DS), caused by the triplication of chromosome 21, results in a constellation of clinical features including changes in intellectual and motor function. Although altered neural development and function have been well
Externí odkaz:
https://doaj.org/article/d4b35132fe2e4d9a88c940a86424aa8a
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 9 (2020)
Mouse models of Down syndrome (DS) have been invaluable tools for advancing knowledge of the underlying mechanisms of intellectual disability in people with DS. The Ts(1716)65Dn (Ts65Dn) mouse is one of the most commonly used models as it recapitulat
Externí odkaz:
https://doaj.org/article/61f4148cd77046ca8aeed53a7a8176bd
Autor:
Nadine M. Aziz, Faycal Guedj, Jeroen L. A. Pennings, Jose Luis Olmos-Serrano, Ashley Siegel, Tarik F. Haydar, Diana W. Bianchi
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 6 (2018)
Down syndrome (DS) results from triplication of human chromosome 21. Neuropathological hallmarks of DS include atypical central nervous system development that manifests prenatally and extends throughout life. As a result, individuals with DS exhibit
Externí odkaz:
https://doaj.org/article/4afb9f40e6dd49c0acc6497a27082010
Publikováno v:
Disease Models & Mechanisms
article-version (VoR) Version of Record
Disease Models & Mechanisms, Vol 13, Iss 9 (2020)
article-version (VoR) Version of Record
Disease Models & Mechanisms, Vol 13, Iss 9 (2020)
Mouse models of Down syndrome (DS) have been invaluable tools for advancing knowledge of the underlying mechanisms of intellectual disability in people with DS. The Ts(1716)65Dn (Ts65Dn) mouse is one of the most commonly used models as it recapitulat
Autor:
Jenny A. Klein, Tarik F. Haydar, Morgan R. Brady, Jose Luis Olmos-Serrano, Nadine M. Aziz, Vittorio Gallo
Publikováno v:
Journal of Neurodevelopmental Disorders
Journal of Neurodevelopmental Disorders, Vol 11, Iss 1, Pp 1-17 (2019)
Journal of Neurodevelopmental Disorders, Vol 11, Iss 1, Pp 1-17 (2019)
BackgroundDown syndrome (DS), caused by the triplication of chromosome 21, results in a constellation of clinical features including changes in intellectual and motor function. Although altered neural development and function have been well described
Autor:
Tarik F. Haydar, Jose Luis Olmos-Serrano, Joseph W. Goodliffe, Nadine M. Aziz, Diana W. Bianchi, Faycal Guedj, Jeroen L. A. Pennings
Publikováno v:
The Journal of Neuroscience. 36:2926-2944
Studies in humans with Down syndrome (DS) show that alterations in fetal brain development are followed by postnatal deficits in neuronal numbers, synaptic plasticity, and cognitive and motor function. This same progression is replicated in several m
Autor:
Diana W. Bianchi, Ashley E Siegel, Nadine M. Aziz, Faycal Guedj, Jeroen L. A. Pennings, Jose Luis Olmos-Serrano, Tarik F. Haydar
Publikováno v:
Disease Models & Mechanisms
Disease Models & Mechanisms, Vol 11, Iss 6 (2018)
Disease Models & Mechanisms, Vol 11, Iss 6 (2018)
Down syndrome (DS) results from triplication of human chromosome 21. Neuropathological hallmarks of DS include atypical central nervous system development that manifests prenatally and extends throughout life. As a result, individuals with DS exhibit
Autor:
Grant L. Austin, Zhengqiu Zhou, M. Kathryn Brewer, John J. McCarthy, Nadine M. Aziz, Zoe R. Simmons, Annette Uittenbogaard, Jason A. Brandon, Peter J. Roach, Dustin Armstrong, Matthew S. Gentry, Ramon C. Sun, Tracy R. McKnight, Jill Zeller, Dyann M. Segvich, Bradley L. Hodges, Lyndsay E.A. Young, Anna A. DePaoli-Roach, James R. Pauly
Publikováno v:
Cell Metab
Summary Lafora disease (LD) is a fatal childhood epilepsy caused by recessive mutations in either the EPM2A or EPM2B gene. A hallmark of LD is the intracellular accumulation of insoluble polysaccharide deposits known as Lafora bodies (LBs) in the bra
Publikováno v:
Molecular Genetics and Metabolism. 126:S24
Autor:
Benjamin Wolozin, Grzegorz Rymarczyk, Michael T. Kirber, Qingde Zhou, Allen Yen, Victoria M. Bolotina, Hirohide Asai, Chelsea Trengrove, Nadine M. Aziz, Tsuneya Ikezu, Gustavo Mostoslavsky
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Nature Communications
Nature Communications
The etiology of idiopathic Parkinson's disease (idPD) remains enigmatic despite recent successes in identification of genes (PARKs) that underlie familial PD. To find new keys to this incurable neurodegenerative disorder we focused on the poorly unde