Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Nadine M Shaban"'
Autor:
Sofia N Moraes, Jordan T Becker, Seyed Arad Moghadasi, Nadine M Shaban, Ashley A Auerbach, Adam Z Cheng, Reuben S Harris
Publikováno v:
eLife, Vol 11 (2022)
Viruses have evolved diverse mechanisms to antagonize host immunity such as direct inhibition and relocalization of cellular APOBEC3B (A3B) by the ribonucleotide reductase (RNR) of Epstein-Barr virus. Here, we investigate the mechanistic conservation
Externí odkaz:
https://doaj.org/article/62fa70d70b3b4647b32f816eb1942dd8
Autor:
Eric W Refsland, Judd F Hultquist, Elizabeth M Luengas, Terumasa Ikeda, Nadine M Shaban, Emily K Law, William L Brown, Cavan Reilly, Michael Emerman, Reuben S Harris
Publikováno v:
PLoS Genetics, Vol 10, Iss 11, p e1004761 (2014)
The Vif protein of HIV-1 allows virus replication by degrading several members of the host-encoded APOBEC3 family of DNA cytosine deaminases. Polymorphisms in both host APOBEC3 genes and the viral vif gene have the potential to impact the extent of v
Externí odkaz:
https://doaj.org/article/57861d10d259422298ec574873c6613b
Autor:
Sofia N. Moraes, Zhiheng Yu, Rui Yan, Ke Shi, Adam Z. Cheng, Michael A. Carpenter, Reuben S. Harris, Jason S. McLellan, Nadine M. Shaban
Viruses use a plethora of mechanisms to evade immune responses. A new example is neutralization of the nuclear DNA cytosine deaminase APOBEC3B by the Epstein-Barr virus (EBV) ribonucleotide reductase subunit BORF2. Cryo-EM studies of APOBEC3B-BORF2 c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c1ff565839475d03b4e95fdcf5f86a3
https://doi.org/10.1101/2021.08.30.458246
https://doi.org/10.1101/2021.08.30.458246
Autor:
Jiayi Wang, Hideki Aihara, Daniel J. Salamango, Ke Shi, Jordan T. Becker, Reuben S. Harris, Nadine M. Shaban, Kate V. Lauer
Publikováno v:
J Mol Biol
As many as five members of the APOBEC3 family of DNA cytosine deaminases are capable of inhibiting HIV-1 replication by deaminating viral cDNA cytosines and interfering with reverse transcription. HIV-1 counteracts restriction with the virally encode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d46937283c8740cfc6a64ea922fadfc
https://doi.org/10.1016/j.jmb.2019.09.014
https://doi.org/10.1016/j.jmb.2019.09.014
Autor:
Adam Z. Cheng, Craig J. Bierle, Peter J. Southern, Reuben S. Harris, Nadine M. Shaban, Elisa Fanunza, Sofia N. Moraes, Wade A. Bresnahan, Stephen A. Rice
Publikováno v:
Viruses, Vol 13, Iss 390, p 390 (2021)
Viruses
Viruses
The apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like (APOBEC) family of DNA cytosine deaminases provides a broad and overlapping defense against viral infections. Successful viral pathogens, by definition, have evolved strategies to e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de5d6e7e2d9498fb4d6950c2759cc05
https://www.mdpi.com/1999-4915/13/3/390
https://www.mdpi.com/1999-4915/13/3/390
Autor:
Edyta Marcon, Nadine M. Shaban, Matthew C. Jarvis, Ivan Borozan, Jack Greenblatt, Natasha Malik-Soni, William L. Brown, Diako Ebrahimi, Adam Z. Cheng, Lori Frappier, Reuben S. Harris, Michael A. Carpenter, Jaime Yockteng-Melgar, Jennifer L. McCann
Publikováno v:
Nature Microbiology. 4:78-88
The apolipoprotein B messenger RNA editing enzyme, catalytic polypeptide-like (APOBEC) family of single-stranded DNA (ssDNA) cytosine deaminases provides innate immunity against virus and transposon replication1-4. A well-studied mechanism is APOBEC3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5bb8496814e11b7ddf64a24726d315b
https://doi.org/10.1038/s41564-018-0284-6
https://doi.org/10.1038/s41564-018-0284-6
Autor:
Daniel J. Salamango, Adam Z. Cheng, Nadine M. Shaban, Jeongsik Yong, Jennifer L. McCann, William L. Brown, Terumasa Ikeda, Diako Ebrahimi, Reuben S. Harris, Gabriel J. Starrett, Michael A. Carpenter, Jairam R. Lingappa, Christopher M. Richards, Jordan T. Becker, Jiayi Wang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications
Nature Communications
Human APOBEC3H (A3H) is a single-stranded DNA cytosine deaminase that inhibits HIV-1. Seven haplotypes (I–VII) and four splice variants (SV154/182/183/200) with differing antiviral activities and geographic distributions have been described, but th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c96fbdb29358874c7b9d118d101cdedc
http://link.springer.com/article/10.1038/s41467-018-06594-3
http://link.springer.com/article/10.1038/s41467-018-06594-3
Autor:
Nadine M. Shaban, Matthew C. Jarvis, Hilde Nilsen, Gabriel J. Starrett, Sterre Leenen, Reuben S. Harris, Daniel J. Salamango, William L. Brown, Artur A. Serebrenik
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(44)
Human cells express up to 9 active DNA cytosine deaminases with functions in adaptive and innate immunity. Many cancers manifest an APOBEC mutation signature and APOBEC3B (A3B) is likely the main enzyme responsible. Although significant numbers of AP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73f5ed127cddab41557291bdcbb284f5
https://pubmed.ncbi.nlm.nih.gov/31611371
https://pubmed.ncbi.nlm.nih.gov/31611371
Autor:
Reuben S. Harris, Nadine M. Shaban, Artur A. Serebrenik, Daniel J. Salamango, William L. Brown, A. St Martin
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
The prospect of introducing a single C-to-T change at a specific genomic location has become feasible with APOBEC-Cas9 editing technologies. We present a panel of eGFP reporters for quantification and optimization of single base editing by APOBEC-Cas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a3d7c4258344812e102453d4ad592e2
https://doi.org/10.1038/s41598-018-36739-9
https://doi.org/10.1038/s41598-018-36739-9
Autor:
Michael A. Carpenter, Rommie E. Amaro, Ke Shi, Kayo Kurahashi, Daniel A. Harki, Hideki Aihara, Justin V. Duffy, Surajit Banerjee, Jennifer L. McCann, Nadine M. Shaban, Daniel J. Salamango, Özlem Demir, Gabriel J. Starrett, Reuben S. Harris
Publikováno v:
Nature structural & molecular biology
APOBEC-catalyzed cytosine-to-uracil deamination of single-stranded (ss)DNA has beneficial functions in immunity and detrimental roles in cancer. APOBEC enzymes have intrinsic dinucleotide specificities that impart hallmark mutation signatures. Despit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f76474941a4b2646ff3c347b4b83c74a
https://doi.org/10.1038/nsmb.3344
https://doi.org/10.1038/nsmb.3344