Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Nadine Lehmann"'
Autor:
Nicole Ziegler, Mariela Cortés-López, Francesca Alt, Maximilian Sprang, Arsenij Ustjanzew, Nadine Lehmann, Khalifa El Malki, Arthur Wingerter, Alexandra Russo, Olaf Beck, Sebastian Attig, Lea Roth, Julian König, Claudia Paret, Jörg Faber
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTDespite massive improvements in the treatment of B-ALL through CART-19 immunotherapy, a large number of patients suffer a relapse due to loss of the targeted epitope. Mutations in the CD19 locus and aberrant splicing events are known to accou
Externí odkaz:
https://doaj.org/article/2b706a5b32624427bf13e1bdcb10eeb5
Autor:
Nadine Lehmann, Claudia Paret, Khalifa El Malki, Alexandra Russo, Marie Astrid Neu, Arthur Wingerter, Larissa Seidmann, Sebastian Foersch, Nicole Ziegler, Lea Roth, Nora Backes, Roger Sandhoff, Joerg Faber
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Papillary renal cell carcinoma (PRCC) is a rare entity in children with no established therapy protocols for advanced diseases. Immunotherapy is emerging as an important therapeutic tool for childhood cancer. Tumor cells can be recognized and killed
Externí odkaz:
https://doaj.org/article/e138c3c0e30c4a50b0b943bb2fc60865
Autor:
Sandra Stössel, Marie A. Neu, Arthur Wingerter, Wilhelm Bloch, Philipp Zimmer, Claudia Paret, Khalifa El Malki, Freerk T. Baumann, Alexandra Russo, Nicole Henninger, Nadine Lehmann, Henrike Otto, Jörg Faber
Publikováno v:
Frontiers in Pediatrics, Vol 8 (2020)
Objective: In cancer patients, the impairment in muscle function is a frequently observed phenomenon. However, comprehensive evaluation of the effect of exercise training on muscle function in childhood cancer patients (CCPs) is sparse and therefore
Externí odkaz:
https://doaj.org/article/4c37caae9ca7403baef8bdd3b80d3a74
Autor:
Claudia Paret, Nadine Lehmann, Hannah Bender, Maximilian Sprang, Clemens J. Sommer, Denis Cana, Larissa Seidmann, Arthur Wingerter, Marie A. Neu, Khalifa El Malki, Francesca Alt, Lea Roth, Federico Marini, Malte Ottenhausen, Martin Glaser, Markus Knuf, Alexandra Russo, Joerg Faber
Publikováno v:
Cancers, Vol 13, Iss 22, p 5838 (2021)
Medulloblastoma is the most common malignant brain tumor in children. Immunotherapy is yet to demonstrate dramatic results in medulloblastoma, one reason being the low rate of mutations creating new antigens in this entity. In tumors with low mutatio
Externí odkaz:
https://doaj.org/article/ef2a8eb1cda543319a2d2d59080d5609
Autor:
Arthur Wingerter, Khalifa El Malki, Roger Sandhoff, Larissa Seidmann, Daniel-Christoph Wagner, Nadine Lehmann, Nadine Vewinger, Katrin B. M. Frauenknecht, Clemens J. Sommer, Frank Traub, Thomas Kindler, Alexandra Russo, Henrike Otto, André Lollert, Gundula Staatz, Lea Roth, Claudia Paret, Jörg Faber
Publikováno v:
Cancers, Vol 13, Iss 3, p 520 (2021)
The ganglioside GD2 is an important target in childhood cancer. Nevertheless, the only therapy targeting GD2 that is approved to date is the monoclonal antibody dinutuximab, which is used in the therapy of neuroblastoma. The relevance of GD2 as a tar
Externí odkaz:
https://doaj.org/article/977280ead9cc4b928ad76f0b8aa9e6af
Autor:
Olaf Beck, Claudia Paret, Alexandra Russo, Jürgen Burhenne, Margaux Fresnais, Kevin Steimel, Larissa Seidmann, Daniel-Christoph Wagner, Nadine Vewinger, Nadine Lehmann, Maximilian Sprang, Nora Backes, Lea Roth, Marie Astrid Neu, Arthur Wingerter, Nicole Henninger, Khalifa El Malki, Henrike Otto, Francesca Alt, Alexander Desuki, Thomas Kindler, Joerg Faber
Publikováno v:
Cancers, Vol 12, Iss 4, p 793 (2020)
Osteosarcoma (OS) is the second most common cause of cancer-related death in pediatric patients. The insulin-like growth factor (IGF) pathway plays a relevant role in the biology of OS but no IGF targeted therapies have been successful as monotherapy
Externí odkaz:
https://doaj.org/article/4063335c588a4ac58e55fb80a34395cc
Autor:
Alexandra Russo, Claudia Paret, Francesca Alt, Jürgen Burhenne, Margaux Fresnais, Wolfgang Wagner, Martin Glaser, Hannah Bender, Sabrina Huprich, Patrick N. Harter, Katharina Filipski, Nadine Lehmann, Nora Backes, Lea Roth, Larissa Seidmann, Clemens Sommer, Marc A. Brockmann, Torsten Pietsch, Marie A. Neu, Arthur Wingerter, Jörg Faber
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 17, p 4267 (2019)
The insulin-like growth factor (IGF) pathway plays an important role in several brain tumor entities. However, the lack of inhibitors crossing the blood−brain barrier remains a significant obstacle for clinical translation. Here, we targeted the IG
Externí odkaz:
https://doaj.org/article/1e910f23e4c146c898b6d61725250cc8
Autor:
Nadine Vewinger, Sabrina Huprich, Larissa Seidmann, Alexandra Russo, Francesca Alt, Hannah Bender, Clemens Sommer, David Samuel, Nadine Lehmann, Nora Backes, Lea Roth, Patrick N. Harter, Katharina Filipski, Jörg Faber, Claudia Paret
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 12, p 3027 (2019)
(1) Background: The high-grade neuroepithelial tumor of the central nervous system with BCOR alteration (HGNET-BCOR) is a highly malignant tumor. Preclinical models and molecular targets are urgently required for this cancer. Previous data suggest a
Externí odkaz:
https://doaj.org/article/91e21fd6f8f047bdb6518a70a6a1821a
Autor:
Jörg Faber, Niklas Joisten, Nadine Lehmann, Sandra Stössel, Wilhelm Bloch, Claudia Paret, Khalifa El Malki, Matteo Winker, Philipp Zimmer, Marie A. Neu
Publikováno v:
Supportive Care in Cancer. 30:2905-2908
While exercise and physical activity have been suggested to reduce mortality and symptoms in cancer, knowledge on these associations in patients with childhood cancer (CCPs) is sparse. Anti-inflammatory properties of exercise might mediate these bene
Autor:
Markus Kienast, Samuel H. Davin, Moritz F. Lehmann, Carolyn Buchwald, Evan N. Edinger, Nadine Lehmann, Owen A. Sherwood
Publikováno v:
Biogeosciences, Vol 18, Pp 4491-4510 (2021)
The flow of Pacific water to the North Atlantic exerts a globally significant control on nutrient balances between the two ocean basins and strongly influences biological productivity in the northwest Atlantic. Nutrient ratios of nitrate (NO3-) versu