Monomeric C‐reactive protein modulates classic complement activation on necrotic cells

Autor: Nadine Lauer, Kristin Stelzner, Hans W. M. Niessen, Michael Mihlan, Peter F. Zipfel, Koba Kupreishvili, Frida C Bergstrom, Anna M. Blom

Publikováno v: Mihlan, M, Blom, A M, Kupreishvili, K, Lauer, N, Stelzner, K, Bergstrom, F, Niessen, H W M & Zipfel, P F 2011, ' Monomeric C-reactive protein modulates classic complement activation on necrotic cells ', FASEB Journal, vol. 25, no. 12, pp. 4198-4210 . https://doi.org/10.1096/fj.11-186460
FASEB Journal, 25(12), 4198-4210. FASEB

The acute-phase protein C-reactive protein (CRP) recruits C1q to the surface of damaged cells and thereby initiates complement activation. However, CRP also recruits complement inhibitors, such as C4b-binding protein (C4bp) and factor H, which both b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc494c99c9e976047b1778e37d3eace
https://doi.org/10.1096/fj.11-186460

Critical involvement of hydrogen peroxide in exercise-induced up-regulation of endothelial NO synthase

Autor: Wilfried Meyer, David G. Harrison, Ralf Jacob, Nadine Lauer, Georg Kojda, Ulrich Rüther, Tatsiana Suvorava

Publikováno v: Cardiovascular Research. 65:254-262

Objective : Recent studies from our groups have indicated that endothelial nitric oxide synthase (eNOS) expression is increased in cell culture by both shear stress and by hydrogen peroxide (H2O2). In vivo, exercise training, known to increase both e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c352debe35a2df47c1f0362e2f07f2e3
https://doi.org/10.1016/j.cardiores.2004.09.010

Upregulation of Vascular NAD(P)H Oxidase Subunit gp91phox and Impairment of the Nitric Oxide Signal Transduction Pathway in Hypertension

Autor: Henning Morawietz, Georg Kojda, Andreas Hacker, Martina Weber, Uwe Rueckschloss, Nadine Lauer

Publikováno v: Biochemical and Biophysical Research Communications. 285:1130-1135

In this study we analyzed the role of vascular NAD(P)H oxidase in the generation of O−2 and the endothelial impairment of NO signal transduction pathway in hypertension. In aortic rings of 15-month-old stroke-prone spontaneously hypertensive rats (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d71594a475be4ac5728c1f3482664502
https://doi.org/10.1006/bbrc.2001.5312

Defective Complement Action and Control Defines Disease Pathology for Retinal and Renal Disorders and Provides a Basis for New Therapeutic Approaches

Autor: Nadine Lauer, Peter F. Zipfel

Publikováno v: Complement Therapeutics ISBN: 9781461441175

The complement system is a central homeostatic system of the vertebrate organism and part of innate immunity. When activated, complement has multiple functions and drives homeostasis and the elimination of infectious microbes (Walport MJ (2001) N Eng

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9291b78d43ad858465b9dbe2caef7b77
https://doi.org/10.1007/978-1-4614-4118-2_11

Complement factor H binds malondialdehyde epitopes and protects from oxidative stress

Autor: Keiryn L. Bennett, David Weismann, James T. Handa, Christoph J. Binder, Giulio Superti-Furga, Hubert Brandstätter, Marisol Cano, Karsten Hartvigsen, Sotirios Tsimikas, Hendrik P. N. Scholl, Peter F. Zipfel, Joseph L. Witztum, Christine Skerka, Nadine Lauer, Peter Charbel Issa

Publikováno v: Nature. 478(7367)

Oxidative stress and enhanced lipid peroxidation are linked to many chronic inflammatory diseases, including age-related macular degeneration (AMD). AMD is the leading cause of blindness in Western societies, but its aetiology remains largely unknown

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2241abd00e157142f1d4f9e30afdbe4
https://pubmed.ncbi.nlm.nih.gov/21979040