Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Nadine L Wicks"'
Autor:
Jan M Bruder, Zachary A Pfeiffer, Jonathan M Ciriello, Diana M Horrigan, Nadine L Wicks, Benjamin Flaherty, Elena Oancea
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43465 (2012)
Melanocytes present in skin and other organs synthesize and store melanin pigment within membrane-delimited organelles called melanosomes. Exposure of human skin to ultraviolet radiation (UV) stimulates melanin production in melanosomes, followed by
Externí odkaz:
https://doaj.org/article/587c24838ab647e3a8e01b3d54b1f4df
Publikováno v:
Proceedings of the National Academy of Sciences. 108:609-614
Voltage gating of hyperpolarization-activated cation (HCN) channels is potentiated by direct binding of cAMP to a cytoplasmic cAMP-sensing domain (CSD). When unliganded, the CSD inhibits hyperpolarization-dependent opening of the HCN channel gate; cA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9058558a197cd7d3531138b86d27e895
https://doi.org/10.1073/pnas.1012750108
https://doi.org/10.1073/pnas.1012750108
Publikováno v:
Photochemistry and Photobiology
Human skin is constantly exposed to solar light containing visible and ultraviolet radiation (UVR), a powerful skin carcinogen. UVR elicits cellular responses in epidermal cells via several mechanisms: direct absorption of short-wavelength UVR photon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5c4f1a4d1375e6e6be24b81c42a0db4
https://pubmed.ncbi.nlm.nih.gov/25267311
https://pubmed.ncbi.nlm.nih.gov/25267311
Autor:
Benjamin Flaherty, Elena Oancea, Jan M. Bruder, Jonathan M. Ciriello, Diana M. Horrigan, Zachary Pfeiffer, Nadine L. Wicks
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 8, p e43465 (2012)
PLoS ONE, Vol 7, Iss 8, p e43465 (2012)
Melanocytes present in skin and other organs synthesize and store melanin pigment within membrane-delimited organelles called melanosomes. Exposure of human skin to ultraviolet radiation (UV) stimulates melanin production in melanosomes, followed by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05017e21ef49128a5f7fc8ac3e8fc5e
http://europepmc.org/articles/PMC3425493
http://europepmc.org/articles/PMC3425493
SummaryExposure of human skin to solar ultraviolet radiation (UVR), a powerful carcinogen [1] comprising ∼95% ultraviolet A (UVA) and ∼5% ultraviolet B (UVB) at the Earth's surface, promotes melanin synthesis in epidermal melanocytes [2, 3], whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b0b137a5f58e138ed21d0bd8de2ccbc
https://europepmc.org/articles/PMC3586554/
https://europepmc.org/articles/PMC3586554/
Autor:
Elena, Oancea, Nadine L, Wicks
Publikováno v:
Advances in experimental medicine and biology. 704
TRPM1, initially named Melastatin, is the founding member of the TRPM subfamily of Transient Receptor Potential (TRP) ion channels. Despite sustained efforts, the molecular properties and physiological functions of TRPM1 remained elusive until recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6f097f99e63683cd324c0f3559702eb9
https://pubmed.ncbi.nlm.nih.gov/21290293
https://pubmed.ncbi.nlm.nih.gov/21290293
Autor:
Elena Oancea, Nadine L. Wicks
Publikováno v:
Transient Receptor Potential Channels ISBN: 9789400702646
TRPM1, initially named Melastatin, is the founding member of the TRPM subfamily of Transient Receptor Potential (TRP) ion channels. Despite sustained efforts, the molecular properties and physiological functions of TRPM1 remained elusive until recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fa1f23f57a3f3a10dc4d3ee44193ade
https://doi.org/10.1007/978-94-007-0265-3_7
https://doi.org/10.1007/978-94-007-0265-3_7
Publikováno v:
Pflugers Archiv : European journal of physiology. 458(5)
Hyperpolarisation–activation of HCN ion channels relies on the movement of a charged S4 transmembrane helix, preferentially stabilising the open conformation of the ion pore gate. The open state is additionally stabilised, (a) when cyclic AMP (cAMP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5370d30d450f0079da7d3cc96f161b97
https://pubmed.ncbi.nlm.nih.gov/19544068
https://pubmed.ncbi.nlm.nih.gov/19544068
Publikováno v:
Biophysical Journal. 96(3):484a-485a
HCN ion channels belong to the voltage-gated K-channel superfamily, but their voltage-sensing (S4) helices produce an unusual hyperpolarization-activation mechanism. This hyperpolarization-activation can be enhanced by (a) cyclic AMP (cAMP) binding t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a3cdf4191fca390db8d4d286a5e7d1e
Autor:
Bruder, Jan M.1, Pfeiffer, Zachary A.1, Ciriello, Jonathan M.1, Horrigan, Diana M.1, Wicks, Nadine L.1, Flaherty, Benjamin1, Oancea, Elena1 elena_oancea@brown.edu, Slominski, Andrzej T.2
Publikováno v:
PLoS ONE. Aug2012, Vol. 7 Issue 8, Special section p1-14. 14p.