Výsledky vyhledávání - "Nadine L, Samara"

Akademický článek

A Toxoplasma gondii O-glycosyltransferase that modulates bradyzoite cyst wall rigidity is distinct from host homologues

Autor: Pranav Kumar, Tadakimi Tomita, Thomas A. Gerken, Collin J. Ballard, Yong Sok Lee, Louis M. Weiss, Nadine L. Samara

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract Infection with the apicomplexan protozoan Toxoplasma gondii can be life-threatening in immunocompromised hosts. Transmission frequently occurs through the oral ingestion of T. gondii bradyzoite cysts, which transition to tachyzoites, dissemi

Externí odkaz: https://doaj.org/article/38f632452ed54bc1842575fe1d9de860

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Akademický článek

A novel role for GalNAc-T2 dependent glycosylation in energy homeostasis

Autor: Cristy R.C. Verzijl, Federico Oldoni, Natalia Loaiza, Justina C. Wolters, Antoine Rimbert, E. Tian, Weiming Yang, Dicky Struik, Marieke Smit, Niels J. Kloosterhuis, Amy J. Fernandez, Nadine L. Samara, Kelly G. Ten Hagen, Kruti Dalal, Aliona Chernish, Peggy McCluggage, Lawrence A. Tabak, Johan W. Jonker, Jan Albert Kuivenhoven

Publikováno v: Molecular Metabolism, Vol 60, Iss , Pp 101472- (2022)

Objective: GALNT2, encoding polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2), was initially discovered as a regulator of high-density lipoprotein metabolism. GalNAc-T2 is known to exert these effects through post-translational modification

Externí odkaz: https://doaj.org/article/ed1b5a2f73a641f4a58ccdb15e609510

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Akademický článek

A molecular switch orchestrates enzyme specificity and secretory granule morphology

Autor: Suena Ji, Nadine L. Samara, Leslie Revoredo, Liping Zhang, Duy T. Tran, Kayla Muirhead, Lawrence A. Tabak, Kelly G. Ten Hagen

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

Regulated secretion is an essential process that requires packing and maturation of cargo proteins in membranous secretory granules. Here, authors identify a gene, pgant9, that influences the glycosylation status of the secretory cargo as well as the

Externí odkaz: https://doaj.org/article/1955994d66254a509ac60c07ad959d67

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Differential splicing of the lectin domain of an O-glycosyltransferase modulates both peptide and glycopeptide preferences

Autor: Carolyn May, Thomas A. Gerken, Zulfeqhar Syed, Leslie Revoredo, Earnest James Paul Daniel, Nadine L. Samara, Kelly G. Ten Hagen, Suena Ji, Lawrence A. Tabak

Publikováno v: Journal of Biological Chemistry. 295:12525-12536

Mucin-type O-glycosylation is an essential post-translational modification required for protein secretion, extracellular matrix formation, and organ growth. O-Glycosylation is initiated by a large family of enzymes (GALNTs in mammals and PGANTs in Dr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c1268fe17e6ba6c7ad9b4faacf8b0791
https://doi.org/10.1074/jbc.ra120.014700

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Furin cleavage of the SARS-CoV-2 spike is modulated by O -glycosylation

Autor: Liping Zhang, Zulfeqhar Syed, Lawrence A. Tabak, Hayley M Reynolds, Matthew Mann, Nadine L. Samara, E Tian, Darryl C. Zeldin, Kelly G. Ten Hagen

Publikováno v: bioRxiv
article-version (status) pre
article-version (number) 1
Proceedings of the National Academy of Sciences of the United States of America

Significance The novel SARS-CoV-2 coronavirus that is responsible for the global pandemic contains a unique insertion of four amino acids within the spike protein (S). Furin cleavage at this novel insertion site has been shown to increase pseudoviral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::879a98958b29b9fa851adc8172092712
https://doi.org/10.1073/pnas.2109905118

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O‐glycosylation of the novel SARS‐CoV‐2 coronavirus spike protein influences furin cleavage

Autor: Lawrence A. Tabak, Darryl C. Zeldin, Hayley M Reynolds, Negin P. Martin, Matthew Mann, Nadine L. Samara, E Tian, Liping Zhang, Kelly G. Ten Hagen, Zulfeqhar Syed

Publikováno v: The FASEB Journal

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the pandemic that has affected millions of people worldwide. This virus contains a unique polybasic insertion (PRRA) within the spike protein, resulting in a novel furin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afb74bdfdd9841e3bfe5a7890cdcc006
http://europepmc.org/articles/PMC8239757

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Cation trafficking propels RNA hydrolysis

Autor: Wei Yang, Nadine L. Samara

Publikováno v: Nature Structural & Molecular Biology. 25:715-721

Catalysis by members of the RNase H superfamily of enzymes is generally believed to require only two Mg2+ ions that are coordinated by active-site carboxylates. By examining the catalytic process of Bacillus halodurans RNase H1 in crystallo, however,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d7dd761ca37c145816b939f6cb31423
https://doi.org/10.1038/s41594-018-0099-4

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The structure of the colorectal cancer-associated enzyme GalNAc-T12 reveals how nonconserved residues dictate its function

Autor: Lawrence A. Tabak, Amy J. Fernandez, Sai Pooja Mahajan, Nadine L. Samara, Thomas A. Gerken, Earnest James Paul Daniel, Jeffrey J. Gray

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance While it is well established that heavily O-glycosylated mucins are essential for normal gastrointestinal function, it is not known how polypeptide N-acetylgalactosaminyl transferase (GalNAc-T12)–specific O-glycans may be contributing.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::831b734d06d35f142aed6da4417d1e7f
https://pubmed.ncbi.nlm.nih.gov/31548401

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Evolution of Inosine-Specific Endonuclease V from Bacterial DNase to Eukaryotic RNase

Autor: Isao Kuraoka, Jinjun Wu, Wei Yang, Nadine L. Samara

Publikováno v: Mol Cell

Summary Endonuclease V (EndoV) cleaves the second phosphodiester bond 3′ to a deaminated adenosine (inosine). Although highly conserved, EndoV homologs change substrate preference from DNA in bacteria to RNA in eukaryotes. We have characterized End

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c3d0776d83e41d426e22eb10c3de2c7
https://pubmed.ncbi.nlm.nih.gov/31444105

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Detection of Reaction Intermediates in Mg

Autor: Nadine L, Samara, Yang, Gao, Jinjun, Wu, Wei, Yang

Publikováno v: Methods in enzymology. 592

Structures of enzyme-substrate/product complexes have been studied for over four decades but have been limited to either before or after a chemical reaction. Recently using in crystallo catalysis combined with X-ray diffraction, we have discovered th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::45b233071ae2acb000836e7428b51999
https://pubmed.ncbi.nlm.nih.gov/28668125

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