Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Nadine Krüger"'
Autor:
Franziska K. Kaiser, Mariana Gonzalez Hernandez, Nadine Krüger, Ellinor Englund, Wenjuan Du, Anna Z. Mykytyn, Mathijs P. Raadsen, Mart M. Lamers, Francine Rodrigues Ianiski, Tatiana M. Shamorkina, Joost Snijder, Federico Armando, Georg Beythien, Malgorzata Ciurkiewicz, Tom Schreiner, Eva Gruber-Dujardin, Martina Bleyer, Olga Batura, Lena Erffmeier, Rabea Hinkel, Cheila Rocha, Monica Mirolo, Dubravka Drabek, Berend-Jan Bosch, Mark Emalfarb, Noelia Valbuena, Ronen Tchelet, Wolfgang Baumgärtner, Markku Saloheimo, Stefan Pöhlmann, Frank Grosveld, Bart L. Haagmans, Albert D.M.E. Osterhaus
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Monoclonal antibodies are an increasingly important tool for prophylaxis and treatment of acute virus infections like SARS-CoV-2 infection. However, their use is often restricted due to the time required for development, variable yields and
Externí odkaz:
https://doaj.org/article/98f6041d164849c48be914ce65c5b198
Autor:
Mohammad Zahidul Hasan, Maren Claus, Nadine Krüger, Sarah Reusing, Eline Gall, Christina Bade-Döding, Armin Braun, Carsten Watzl, Markus Uhrberg, Lutz Walter
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
HLA-E expression plays a central role for modulation of NK cell function by interaction with inhibitory NKG2A and stimulatory NKG2C receptors on canonical and adaptive NK cells, respectively. Here, we demonstrate that infection of human primary lung
Externí odkaz:
https://doaj.org/article/922fdbe1e53a41a29cccf93946fdf801
Autor:
Markus Hoffmann, Anzhalika Sidarovich, Prerna Arora, Nadine Krüger, Inga Nehlmeier, Amy Kempf, Luise Graichen, Martin S. Winkler, Daniela Niemeyer, Christine Goffinet, Christian Drosten, Sebastian Schulz, Hans-Martin Jäck, Stefan Pöhlmann
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT SARS-CoV-2 variants of concern (VOC) acquired mutations in the spike (S) protein, including E484K, that confer resistance to neutralizing antibodies. However, it is incompletely understood how these mutations impact viral entry into host cel
Externí odkaz:
https://doaj.org/article/b456191be4ea4ac29d1a309a4697f9af
Autor:
Hannah Kleine-Weber, Simon Schroeder, Nadine Krüger, Alexander Prokscha, Hassan Y. Naim, Marcel A. Müller, Christian Drosten, Stefan Pöhlmann, Markus Hoffmann
Publikováno v:
Emerging Microbes and Infections, Vol 9, Iss 1, Pp 155-168 (2020)
ABSTRACTMiddle East respiratory syndrome (MERS) coronavirus (MERS-CoV) causes a severe respiratory disease in humans. The MERS-CoV spike (S) glycoprotein mediates viral entry into target cells. For this, MERS-CoV S engages the host cell protein dipep
Externí odkaz:
https://doaj.org/article/6c0d81b7e961460e8a7dc357695bbdf0
Autor:
Nadine Krüger, Thales Kronenberger, Hang Xie, Cheila Rocha, Stefan Pöhlmann, Haixia Su, Yechun Xu, Stefan A. Laufer, Thanigaimalai Pillaiyar
Publikováno v:
Pharmaceuticals, Vol 16, Iss 2, p 190 (2023)
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has forced the development of direct-acting antiviral drugs due to the coronavirus disease 2019 (COVID-19) pandemic. The main protease of SARS-CoV-2 is a crucial enzyme that breaks down
Externí odkaz:
https://doaj.org/article/aee043fbfbe24ace8b45cc13804aa9a2
Autor:
Anzhalika Sidarovich, Nadine Krüger, Cheila Rocha, Luise Graichen, Amy Kempf, Inga Nehlmeier, Martin Lier, Anne Cossmann, Metodi V. Stankov, Sebastian R. Schulz, Georg M. N. Behrens, Hans-Martin Jäck, Stefan Pöhlmann, Markus Hoffmann
Publikováno v:
Viruses, Vol 14, Iss 11, p 2475 (2022)
The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) facilitates viral entry into host cells and is the key target for neutralizing antibodies. The SARS-CoV-2 lineage B.1.620 carries fifteen mutations in the S protein
Externí odkaz:
https://doaj.org/article/5777d3dcf3384ed790818719c997e62a
Publikováno v:
Viruses, Vol 14, Iss 7, p 1526 (2022)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic, which has been reported to have caused 18 [...]
Externí odkaz:
https://doaj.org/article/e288826b15b84f25a7e28ff19b282c41
Autor:
Markus Hoffmann, Lu Zhang, Nadine Krüger, Luise Graichen, Hannah Kleine-Weber, Heike Hofmann-Winkler, Amy Kempf, Stefan Nessler, Joachim Riggert, Martin Sebastian Winkler, Sebastian Schulz, Hans-Martin Jäck, Stefan Pöhlmann
Publikováno v:
Cell Reports, Vol 35, Iss 3, Pp 109017- (2021)
Summary: Transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from humans to farmed mink has been observed in Europe and the US. In the infected animals, viral variants arose that harbored mutations in the spike (S) protein, t
Externí odkaz:
https://doaj.org/article/cf114b85f78c491d9f80733acf2b0401
Autor:
Iris Färber, Johannes Krüger, Cheila Rocha, Federico Armando, Maren von Köckritz-Blickwede, Stefan Pöhlmann, Armin Braun, Wolfgang Baumgärtner, Sandra Runft, Nadine Krüger
Publikováno v:
Viruses, Vol 14, Iss 4, p 828 (2022)
Several animal species are susceptible to SARS-CoV-2 infection, as documented by case reports and serological and in vivo infection studies. However, the susceptibility of many animal species remains unknown. Furthermore, the expression patterns of S
Externí odkaz:
https://doaj.org/article/1da3b75e027d440a83541598d6f517e2
Autor:
Nadine Krüger, Cheila Rocha, Sandra Runft, Johannes Krüger, Iris Färber, Federico Armando, Eva Leitzen, Graham Brogden, Gisa Gerold, Stefan Pöhlmann, Markus Hoffmann, Wolfgang Baumgärtner
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10636 (2021)
Natural or experimental infection of domestic cats and virus transmission from humans to captive predatory cats suggest that felids are highly susceptible to SARS-CoV-2 infection. However, it is unclear which cells and compartments of the respiratory
Externí odkaz:
https://doaj.org/article/f13fe1406bcd4f75ae5f1b22e3d1a784