Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Nadine Kaesler"'
Autor:
Fabian Peisker, Maurice Halder, James Nagai, Susanne Ziegler, Nadine Kaesler, Konrad Hoeft, Ronghui Li, Eric M. J. Bindels, Christoph Kuppe, Julia Moellmann, Michael Lehrke, Christian Stoppe, Michael T. Schaub, Rebekka K. Schneider, Ivan Costa, Rafael Kramann
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
The cardiac vascular niche is of major importance in homeostasis and disease, but knowledge of its complexity in response to injury remains limited. Here we combine lineage tracing with single cell RNA sequencing to show alterations in fibroblasts, e
Externí odkaz:
https://doaj.org/article/19f66c2c61bd4908bcd8a5e61c027ad1
Autor:
Xoana Barros, Xenia Friesen, Vincent Mathias Brandenburg, Elisa Anamaria Liehn, Sonja Steppan, Fabian Kiessling, Rafael Kramann, Jürgen Floege, Thilo Krüger, Nadine Kaesler
Publikováno v:
Nutrients, Vol 15, Iss 6, p 1303 (2023)
Cardiovascular complications are accompanied by life-threatening complications and represent the major cause of death in patients with chronic kidney disease (CKD). Magnesium is important for the physiology of cardiac function, and its deficiency is
Externí odkaz:
https://doaj.org/article/f50fb5b79e6043e6a37cd4cca1690150
Autor:
Nikolas Rapp, Vincent M. Brandenburg, Nadine Kaesler, Stephan J. L. Bakker, Robert Stöhr, Alexander Schuh, Pieter Evenepoel, Leon J. Schurgers
Publikováno v:
Nutrients, Vol 13, Iss 10, p 3490 (2021)
Vitamin K dependent proteins (VKDP), such as hepatic coagulation factors and vascular matrix Gla protein (MGP), play key roles in maintaining physiological functions. Vitamin K deficiency results in inactive VKDP and is strongly linked to vascular ca
Externí odkaz:
https://doaj.org/article/fd957b025c754f9bb7b0f2381d50e814
Publikováno v:
Toxins, Vol 12, Iss 3, p 161 (2020)
Cardiac remodeling occurs frequently in chronic kidney disease patients and affects quality of life and survival. Current treatment options are highly inadequate. As kidney function declines, numerous metabolic pathways are disturbed. Kidney and hear
Externí odkaz:
https://doaj.org/article/dd0a2d347b564503a8fab263a7d9d4ef
Autor:
Ilenia Cirilli, Patrick Orlando, Sonia Silvestri, Fabio Marcheggiani, Phiwayinkosi V. Dludla, Nadine Kaesler, Luca Tiano
Publikováno v:
BioFactors. 48:1129-1136
Carboxylative enzymes are involved in many pathways and their regulation plays a crucial role in many of these pathways. In particular, γ-glutamylcarboxylase (GGCX) converts glutamate residues (Glu) into γ-carboxyglutamate (Gla) of the vitamin K-de
Autor:
Nazanin Kabgani, Felix Schreibing, Leon J. Schurgers, Jürgen Floege, Thimoteus Speer, Vera Jankowski, Christoph Kuppe, Christiane Drechsler, Peter Boor, Rafael Kramann, Sofia de la Puente-Secades, Nikolas Rapp, Nadine Kaesler
Publikováno v:
Kidney International, 101(2), 338-348. Elsevier Inc.
Kidney International, 101(2), 338-348. Elsevier Science
Kidney International, 101(2), 338-348. Elsevier Science
Chronic kidney disease (CKD) is accompanied with extensive cardiovascular calcification, in part correlating with functional vitamin K deficiency. Here, we sought to determine causes for vitamin K deficiency beyond reduced dietary intake. Initially,
Publikováno v:
Kidney International. 100:1023-1036
Vitamin K, well known for its role in coagulation, encompasses 2 major subgroups: vitamin K1 is exclusively synthesized by plants, whereas vitamin K2 mostly originates from bacterial synthesis. Vitamin K serves as a cofactor for the enzyme gamma-glut
Autor:
Nazanin Kabgani, Eric Bindels, Christoph Kuppe, Remco Hoogenboezem, Sylvia Menzel, Mahmoud M. Ibrahim, Maurice Halder, Jürgen Floege, Lukas Gernhold, Rafael Kramann, James R Smith, Julio Saez-Rodriguez, Nadine Kaesler, Victor G. Puelles, Katharina C Reimer, Neil C. Henderson, Xiaoting Zhang, Susanne Ziegler, Martin Klaus, Jennifer Kranz, Javier Perales-Patón, Rebekka K. Schneider, Peter Boor, Jitske Jansen, Yaoxian Xu, John R. Wilson-Kanamori, Tobias B. Huber, Ross Dobie, Joachim Steffens
Publikováno v:
Nature, 589(7841), 281-286. Nature Publishing Group
Nature
Kuppe, C, Ibrahim, M M, Kranz, J, Zhang, X, Ziegler, S, Perales-patón, J, Jansen, J, Reimer, K C, Smith, J R, Dobie, R, Wilson-Kanamori, J R, Halder, M, Xu, Y, Kabgani, N, Kaesler, N, Klaus, M, Gernhold, L, Puelles, V G, Huber, T B, Boor, P, Menzel, S, Hoogenboezem, R M, Bindels, E M J, Steffens, J, Floege, J, Schneider, R K, Saez-rodriguez, J, Henderson, N C & Kramann, R 2021, ' Decoding myofibroblast origins in human kidney fibrosis ', Nature, vol. 589, no. 7841, pp. 281–286 . https://doi.org/10.1038/s41586-020-2941-1
Nature
Kuppe, C, Ibrahim, M M, Kranz, J, Zhang, X, Ziegler, S, Perales-patón, J, Jansen, J, Reimer, K C, Smith, J R, Dobie, R, Wilson-Kanamori, J R, Halder, M, Xu, Y, Kabgani, N, Kaesler, N, Klaus, M, Gernhold, L, Puelles, V G, Huber, T B, Boor, P, Menzel, S, Hoogenboezem, R M, Bindels, E M J, Steffens, J, Floege, J, Schneider, R K, Saez-rodriguez, J, Henderson, N C & Kramann, R 2021, ' Decoding myofibroblast origins in human kidney fibrosis ', Nature, vol. 589, no. 7841, pp. 281–286 . https://doi.org/10.1038/s41586-020-2941-1
Kidney fibrosis is the hallmark of chronic kidney disease progression; however, at present no antifibrotic therapies exist1–3. The origin, functional heterogeneity and regulation of scar-forming cells that occur during human kidney fibrosis remain
Autor:
Leon J. Schurgers, Burkhard Hellmann, Jürgen Floege, Claudia Goettsch, Nadine Kaesler, Daniel Weis, Rafael Kramann
Publikováno v:
Nephrology Dialysis Transplantation, 35(1), 65-73. Oxford University Press
Background. Optimal phosphate control is an unmet need in chronic kidney disease (CKD). High serum phosphate increases calcification burden and is associated with mortality and cardiovascular disease in CKD. Nicotinamide (NA) alone or in combination
Autor:
Kerstin Mahr, Mette Nyegard, Joachim Jankowski, Marina Augusto Heuschkel, Simon Winther, Morten Bøttcher, Nadine Kaesler, Vera Jankowski, Anika Himmelsbach, Juliane Hermann, Nikolaus Marx, Stefan J Schunk, Thimoteus Speer, Anders Nykjaer, Turgay Saritas, Søren Thirup, Claudia Goettsch, Mads Kjolby, Juergen Floege, Rafael Kramann
Publikováno v:
Jankowski, V, Saritas, T, Kjolby, M, Hermann, J, Speer, T, Himmelsbach, A, Mahr, K, Heuschkel, M A, Schunk, S J, Thirup, S, Winther, S, Bottcher, M, Nyegard, M, Nykjaer, A, Kramann, R, Kaesler, N, Jankowski, J, Floege, J, Marx, N & Goettsch, C 2022, ' Carbamylated sortilin associates with cardiovascular calcification in patients with chronic kidney disease ', Kidney International, vol. 101, no. 3, pp. 574-584 . https://doi.org/10.1016/j.kint.2021.10.018
Kidney international 101(3), 574-584 (2022). doi:10.1016/j.kint.2021.10.018
Jankowski, V, Saritas, T, Kjolby, M, Hermann, J, Speer, T, Himmelsbach, A, Mahr, K, Heuschkel, M A, Schunk, S J, Thirup, S, Winther, S, Bottcher, M, Nyegaard, M, Nykjaer, A, Kramann, R, Kaesler, N, Jankowski, J, Floege, J, Marx, N & Goettsch, C 2022, ' Carbamylated sortilin associates with cardiovascular calcification in patients with chronic kidney disease. ', Kidney International, vol. 101, no. 3, pp. 574-584 . https://doi.org/10.1016/j.kint.2021.10.018
Kidney international 101(3), 574-584 (2022). doi:10.1016/j.kint.2021.10.018
Jankowski, V, Saritas, T, Kjolby, M, Hermann, J, Speer, T, Himmelsbach, A, Mahr, K, Heuschkel, M A, Schunk, S J, Thirup, S, Winther, S, Bottcher, M, Nyegaard, M, Nykjaer, A, Kramann, R, Kaesler, N, Jankowski, J, Floege, J, Marx, N & Goettsch, C 2022, ' Carbamylated sortilin associates with cardiovascular calcification in patients with chronic kidney disease. ', Kidney International, vol. 101, no. 3, pp. 574-584 . https://doi.org/10.1016/j.kint.2021.10.018
Kidney international 101(3), 574-584 (2022). doi:10.1016/j.kint.2021.10.018
Published by Elsevier, New York, NY
Published by Elsevier, New York, NY