Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Nadine Johnson Farley"'
Publikováno v:
Cancer Chemotherapy and Pharmacology
Purpose To investigate the effectiveness of a combination of 6-thioguanine (6-TG) and pralatrexate (PDX) in methylthioadenosine phosphorylase (MTAP)-deficient T-cell acute lymphoblastic leukemia (T-cell ALL). Methods CCRF-CEM (MTAP−/−) and Molt4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad86ab70ee663f432a141df9659ef878
https://doi.org/10.1007/s00280-015-2747-2
https://doi.org/10.1007/s00280-015-2747-2
Autor:
Nadine Johnson Farley, Jonathan Lewis, Nitu Bansal, Hagop Youssoufian, Lisa Y. Wu, Joseph R. Bertino
Publikováno v:
Molecular Cancer Therapeutics. 14:23-30
Prostate cancer is the leading cause of cancer-related death in men in the United States. A major cause of drug resistance in prostate and other epithelial tumors may be due to the presence of a fraction of tumor cells that retain the ability to init
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe54123d0954f92f35b965679b75fd2c
https://doi.org/10.1158/1535-7163.mct-13-1040
https://doi.org/10.1158/1535-7163.mct-13-1040
Autor:
John E. Kerrigan, Nitu Bansal, Kathleen W. Scotto, Tazeem Shaik, Olga B. Garbuzenko, Debabrata Banerjee, Emine Ercikan Abali, Xiaoqi Xie, Tamara Minko, Joseph R. Bertino, Nadine Johnson-Farley
Publikováno v:
Oncotarget
// Xiaoqi Xie 1 , Nitu Bansal 1 , Tazeem Shaik 1 , John E. Kerrigan 1 , Tamara Minko 2 , Olga Garbuzenko 2 ,Emine Ercikan Abali 3 , Nadine Johnson-Farley 1 , Debabrata Banerjee 1 , Kathleen W. Scotto 1 and Joseph R Bertino 1 1 Rutgers Cancer Institut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee27838e935d30501cf16a6956f362a
https://doi.org/10.18632/oncotarget.1809
https://doi.org/10.18632/oncotarget.1809
Autor:
Kuo-Chieh Lee, Yi-Ching Hsieh, Debabrata Banerjee, Kathleen W. Scotto, Philip M. Tedeschi, Joseph R. Bertino, Nadine Johnson-Farley, Rialnat AdeBisi Lawal, John E. Kerrigan, Emine Ercikan Abali
Publikováno v:
Molecular Pharmacology. 83:339-353
Dihydrofolate reductase (DHFR), because of its essential role in DNA synthesis, has been targeted for the treatment of a wide variety of human diseases, including cancer, autoimmune diseases, and infectious diseases. Methotrexate (MTX), a tight bindi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c83ba3a07d5980c6f222ab16478cf06
https://doi.org/10.1124/mol.112.080218
https://doi.org/10.1124/mol.112.080218
Autor:
Sharathkumar Bhagavathi, Martin Lubin, Wing C. Chan, Lauri Goodell, Nadine Johnson-Farley, Joseph R. Bertino
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 12:306-309
The majority of peripheral T-cell lymphomas were found to lack methylthioadenosine phosphorylase, an enzyme that is essential for the salvage of adenine from methylthioadenosine, a product of polyamine synthesis. Importantly, tumors that lack this en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5e4d95e2adb7787b26fde2ece1c4f2d
https://doi.org/10.1016/j.clml.2012.07.001
https://doi.org/10.1016/j.clml.2012.07.001
Autor:
Benjamin A. Belinka, Brian A. Vega, Joseph R. Bertino, Kristina M. DiFranco, David Elson, Nadine Johnson-Farley, Scott C. Kachlany
Leukotoxin (LtxA) is a protein secreted from the oral bacterium Aggregatibacter actinomycetemcomitans. LtxA binds to the β2 integrin lymphocyte-associated function antigen-1 (LFA-1) on human white blood cells (WBCs), resulting in cell death. LtxA is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be01181e103a2081b9c946937d304527
https://europepmc.org/articles/PMC4553223/
https://europepmc.org/articles/PMC4553223/
Publikováno v:
Journal of Neurochemistry. 93:910-917
5-HT(1A) receptors have been hypothesized to mediate some of the neuronal plasticity and behavioral responses stimulated by serotonin selective reuptake inhibitors. Although the cellular signaling pathways required for inducing these actions have not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6791ebd6da7afe1e5776f962b362798e
https://doi.org/10.1111/j.1471-4159.2005.03107.x
https://doi.org/10.1111/j.1471-4159.2005.03107.x
Publikováno v:
Journal of Neurochemistry. 87:1076-1085
The roles of 3',5'-cyclic adenosine monophosphate (cAMP) and protein kinase A in 5-hydroxytryptamine (5-HT)7 receptor-mediated activation of extracellular-regulated kinase (ERK) were studied in cultured hippocampal neurons and transfected PC12 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5082faf6d18f1cfded7db167e574445
https://doi.org/10.1046/j.1471-4159.2003.02076.x
https://doi.org/10.1046/j.1471-4159.2003.02076.x
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 303:746-752
5-Hydroxytryptamine (5-HT) 2A receptors have been implicated to play a role in both the treatment and pathophysiology of a number of psychiatric disorders. Therefore, the coupling of this receptor to signals, such as extracellular signal-regulated ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7c92287b932ac52bd6f4e2fbd263d06
https://doi.org/10.1124/jpet.102.038083
https://doi.org/10.1124/jpet.102.038083
Publikováno v:
British Journal of Pharmacology. 136:1072-1078
1: Since all 5-HT(1) receptors couple to G(i)-type G proteins and inhibit adenylyl cyclase, the functional significance of five distinct subtypes of 5-HT(1) receptors has been unclear. 2: In previous studies we have used transfected cells to demonstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::740fe39f6c2d29e92d05cf9cbd08ac67
https://doi.org/10.1038/sj.bjp.0704809
https://doi.org/10.1038/sj.bjp.0704809