Zobrazeno 1 - 10
of 172
pro vyhledávání: '"Nadine Jagerovic"'
Autor:
Gemma Navarro, Marc Gómez-Autet, Paula Morales, Joan Biel Rebassa, Claudia Llinas del Torrent, Nadine Jagerovic, Leonardo Pardo, Rafael Franco
Publikováno v:
Pharmacological Research, Vol 208, Iss , Pp 107363- (2024)
G protein-coupled receptors (GPCRs) exist within a landscape of interconvertible conformational states and in dynamic equilibrium between monomers and higher-order oligomers, both influenced by ligand binding. Here, we show that a homobivalent ligand
Externí odkaz:
https://doaj.org/article/0e0661cb783749e1bee2b5a8648b5e8e
Autor:
Rubén Tovar, Marialuisa de Ceglia, Massimo Ubaldi, Miguel Rodríguez-Pozo, Laura Soverchia, Carlo Cifani, Gema Rojo, Ana Gavito, Laura Hernandez-Folgado, Nadine Jagerovic, Roberto Ciccocioppo, Elena Baixeras, Fernando Rodríguez de Fonseca, Juan Decara
Publikováno v:
Nutrients, Vol 15, Iss 20, p 4448 (2023)
Acylethanolamides (NAEs) are bioactive lipids derived from diet fatty acids that modulate important homeostatic functions, including appetite, fatty acid synthesis, mitochondrial respiration, inflammation, and nociception. Among the naturally circula
Externí odkaz:
https://doaj.org/article/cb54f673fc6949d5bcb0b0871a918aa4
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The classical terms agonists and antagonists for G protein coupled receptors (GPCRs) have often become misleading. Even the biased agonism concept does not describe all the possibilities already demonstrated for GPCRs. The cannabinoid CB2 receptor (C
Externí odkaz:
https://doaj.org/article/afbbc5a71e5e4873b7b89ddbc373f385
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Both metabotropic (CBRs) and ionotropic cannabinoid receptors (ICRs) have implications in a range of neurological disorders. The metabotropic canonical CBRs CB1 and CB2 are highly implicated in these pathological events. However, selective targeting
Externí odkaz:
https://doaj.org/article/ac74d42050f64b19959deb4153459339
Autor:
Sonia Burgaz, Concepción García, Claudia Gonzalo-Consuegra, Marta Gómez-Almería, Francisco Ruiz-Pino, Juan Diego Unciti, María Gómez-Cañas, Juan Alcalde, Paula Morales, Nadine Jagerovic, Carmen Rodríguez-Cueto, Eva de Lago, Eduardo Muñoz, Javier Fernández-Ruiz
Publikováno v:
Molecules, Vol 26, Iss 24, p 7643 (2021)
Cannabinoids act as pleiotropic compounds exerting, among others, a broad-spectrum of neuroprotective effects. These effects have been investigated in the last years in different preclinical models of neurodegeneration, with the cannabinoid type-1 (C
Externí odkaz:
https://doaj.org/article/4a88a818e83d475a8337cdef7ec47035
Autor:
Rubén Tovar, Ana Luisa Gavito, Antonio Vargas, Laura Soverchia, Laura Hernandez-Folgado, Nadine Jagerovic, Elena Baixeras, Roberto Ciccocioppo, Fernando Rodríguez de Fonseca, Juan Decara
Publikováno v:
Nutrients, Vol 13, Iss 8, p 2589 (2021)
Obesity is currently a major epidemic in the developed world. However, we lack a wide range of effective pharmacological treatments and therapies against obesity, and those approved are not devoid of adverse effects. Dietary components such as palmit
Externí odkaz:
https://doaj.org/article/be088650bd5e4423bb21c2fdba78c5e1
Autor:
Paula Morales, Nadine Jagerovic
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Cannabis has long been known to limit or prevent nausea and vomiting, lack of appetite, and pain. For this reason, cannabinoids have been successfully used in the treatment of some of the unwanted side effects caused by cancer chemotherapy. Besides t
Externí odkaz:
https://doaj.org/article/619ae7d1b8af479d93fc5ab967797a72
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 3, p 1001 (2021)
Cannabinoids have shown to exert their therapeutic actions through a variety of targets. These include not only the canonical cannabinoid receptors CB1R and CB2R but also related orphan G protein-coupled receptors (GPCRs), ligand-gated ion channels,
Externí odkaz:
https://doaj.org/article/c8cee5daa483427ea113fc07bbbd89fb
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Cannabidiol (CBD) has been traditionally used in Cannabis-based preparation, however historically, it has received far less interest as a single drug than the other components of Cannabis. Currently, CBD generates considerable interest due to its ben
Externí odkaz:
https://doaj.org/article/a99fa04a986b4bacaeef95d0f24ddaeb
Autor:
Paula Morales, Laura Figuerola-Asencio, Dow H. Hurst, Pingwei Zhao, Mary E. Abood, Patricia H. Reggio, Nadine Jagerovic
Publikováno v:
Proceedings, Vol 22, Iss 1, p 92 (2019)
Docking studies of identified GPR55 ligands using a GPR55 inactive state model allow rationalizing key structural features involved in ligand–receptor binding. On this molecular basis, we have designed novel quinolone sulfonamide derivatives with o
Externí odkaz:
https://doaj.org/article/2630e8776f5d4776bbd5423c44a9f3b6