Zobrazeno 1 - 10
of 169
pro vyhledávání: '"Nadine Jagerovic"'
Autor:
Gemma Navarro, Marc Gómez-Autet, Paula Morales, Joan Biel Rebassa, Claudia Llinas del Torrent, Nadine Jagerovic, Leonardo Pardo, Rafael Franco
Publikováno v:
Pharmacological Research, Vol 208, Iss , Pp 107363- (2024)
G protein-coupled receptors (GPCRs) exist within a landscape of interconvertible conformational states and in dynamic equilibrium between monomers and higher-order oligomers, both influenced by ligand binding. Here, we show that a homobivalent ligand
Externí odkaz:
https://doaj.org/article/0e0661cb783749e1bee2b5a8648b5e8e
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The classical terms agonists and antagonists for G protein coupled receptors (GPCRs) have often become misleading. Even the biased agonism concept does not describe all the possibilities already demonstrated for GPCRs. The cannabinoid CB2 receptor (C
Externí odkaz:
https://doaj.org/article/afbbc5a71e5e4873b7b89ddbc373f385
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Both metabotropic (CBRs) and ionotropic cannabinoid receptors (ICRs) have implications in a range of neurological disorders. The metabotropic canonical CBRs CB1 and CB2 are highly implicated in these pathological events. However, selective targeting
Externí odkaz:
https://doaj.org/article/ac74d42050f64b19959deb4153459339
Autor:
Sonia Burgaz, Concepción García, Claudia Gonzalo-Consuegra, Marta Gómez-Almería, Francisco Ruiz-Pino, Juan Diego Unciti, María Gómez-Cañas, Juan Alcalde, Paula Morales, Nadine Jagerovic, Carmen Rodríguez-Cueto, Eva de Lago, Eduardo Muñoz, Javier Fernández-Ruiz
Publikováno v:
Molecules, Vol 26, Iss 24, p 7643 (2021)
Cannabinoids act as pleiotropic compounds exerting, among others, a broad-spectrum of neuroprotective effects. These effects have been investigated in the last years in different preclinical models of neurodegeneration, with the cannabinoid type-1 (C
Externí odkaz:
https://doaj.org/article/4a88a818e83d475a8337cdef7ec47035
Autor:
Paula Morales, Nadine Jagerovic
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Cannabis has long been known to limit or prevent nausea and vomiting, lack of appetite, and pain. For this reason, cannabinoids have been successfully used in the treatment of some of the unwanted side effects caused by cancer chemotherapy. Besides t
Externí odkaz:
https://doaj.org/article/619ae7d1b8af479d93fc5ab967797a72
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Cannabidiol (CBD) has been traditionally used in Cannabis-based preparation, however historically, it has received far less interest as a single drug than the other components of Cannabis. Currently, CBD generates considerable interest due to its ben
Externí odkaz:
https://doaj.org/article/a99fa04a986b4bacaeef95d0f24ddaeb
Autor:
Paula Morales, Laura Figuerola-Asencio, Dow H. Hurst, Pingwei Zhao, Mary E. Abood, Patricia H. Reggio, Nadine Jagerovic
Publikováno v:
Proceedings, Vol 22, Iss 1, p 92 (2019)
Docking studies of identified GPR55 ligands using a GPR55 inactive state model allow rationalizing key structural features involved in ligand–receptor binding. On this molecular basis, we have designed novel quinolone sulfonamide derivatives with o
Externí odkaz:
https://doaj.org/article/2630e8776f5d4776bbd5423c44a9f3b6
Publikováno v:
Proceedings, Vol 22, Iss 1, p 29 (2019)
The orphan G protein coupled receptor 6 (GPR6) is a cannabinoid-related Class A GPCR. It is highly expressed in the central nervous system and exhibits high constitutive activation of adenylyl cyclase. Several research groups have demonstrated that G
Externí odkaz:
https://doaj.org/article/ee178a2bce784273b024a486c58a2acc
Autor:
Paula Morales, Luis Miguel Azofra, José Cumella, Laura Hernandez-Folgado, María Roldán, Ibon Alkorta, Nadine Jagerovic
Publikováno v:
ARKIVOC, Vol 2014, Iss 2, Pp 319-332 (2013)
Externí odkaz:
https://doaj.org/article/87dbac5773974247ab3c2121e74ca608
Autor:
Gema Navarro, Paula Morales, Carmen Rodríguez-Cueto, Javier Fernández-Ruiz, Nadine Jagerovic, Rafael Franco
Publikováno v:
Frontiers in Neuroscience, Vol 10 (2016)
Endocannabinoids activate two types of specific receptors, namely cannabinoid CB1 and CB2. Contrary to the psychotropic actions of agonists of CB1 receptors, and serious side effects of the selective antagonists of this receptor, drugs acting on CB2
Externí odkaz:
https://doaj.org/article/aad44e01b19d415fa58abbd0bca9006f