Dysregulation of a lncRNA within the TNFRSF10A locus activates cell death pathways

Autor: Michael Farkas, Tadeusz Kaczynski, Nadine Husami, Elizabeth Au

TNFRSF10A (tumor necrosis factor receptor superfamily member 10A) encodes a cell surface receptor protein involved in apoptotic, necroptotic, and inflammatory pathways. Dysregulation of TNFRSF10A has been implicated in sensitization to apoptosis and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b5959eef8d773f91838789e4d5e5faba
https://doi.org/10.21203/rs.3.rs-2395063/v1

A systems biology approach uncovers novel disease mechanisms in age-related macular degeneration

Autor: Luz D. Orozco, Leah Owen, Jeffrey Hofmann, Amy D. Stockwell, Jianhua Tao, Susan Haller, Vineeth T. Mukundan, Christine Clarke, Jessica Lund, Akshayalakshmi Sridhar, Julie L. Barr, Rylee A. Zavala, Elijah C. Graves, Charles Zhang, Nadine Husami, Robert Finley, Elizabeth Au, John H. Lillvis, Michael H. Farkas, Akbar Shakoor, Richard M. Sherva, Ivana K. Kim, Joshua S. Kaminker, Michael J. Townsend, Lindsay A. Farrer, Brian L. Yaspan, Hsu-Hsin Chen, Margaret M. DeAngelis

Age-related Macular Degeneration (AMD) is a leading cause of blindness, affecting 200 million people worldwide. We present a comprehensive molecular atlas for different stages of AMD.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a07fcd58dd2422fa1d90174ae6aa8727

Patterns of Gene Expression, Splicing, and Allele-Specific Expression Vary among Macular Tissues and Clinical Stages of Age-Related Macular Degeneration.

Autor: Shwani, Treefa^1,2 (AUTHOR) treefash@buffalo.edu, Zhang, Charles¹ (AUTHOR) czhang62@buffalo.edu, Owen, Leah A.^1,3,4,5 (AUTHOR) akbar.shakoor@hsc.utah.edu, Shakoor, Akbar³ (AUTHOR) albert.vitale@hsc.utah.edu, Vitale, Albert T.³ (AUTHOR), Lillvis, John H.^1,6 (AUTHOR) jhlillvi@buffalo.edu, Barr, Julie L.^1,2 (AUTHOR) jbarr2@buffalo.edu, Cromwell, Parker¹ (AUTHOR) parkercr@buffalo.edu, Finley, Robert¹ (AUTHOR) robert.finley1@hsc.wvu.edu, Husami, Nadine¹ (AUTHOR) nadinehu@buffalo.edu, Au, Elizabeth¹ (AUTHOR) elizabethdgeorge@gmail.com, Zavala, Rylee A.¹ (AUTHOR) ryleezav@buffalo.edu, Graves, Elijah C.¹ (AUTHOR) gravee1@g.ucla.edu, Zhang, Sarah X.^1,2,7 (AUTHOR) xzhang38@buffalo.edu, Farkas, Michael H.^1,2,6,7 (AUTHOR) mhfarkas@buffalo.edu, Ammar, David A.⁸ (AUTHOR) david.ammar@lwvi.org, Allison, Karen M.⁹ (AUTHOR) karen_allison@urmc.rochester.edu, Tawfik, Amany^10,11 (AUTHOR) amtawfik@oakland.edu, Sherva, Richard M.¹² (AUTHOR) sherva@bu.edu, Li, Mingyao¹³ (AUTHOR) mingyao@pennmedicine.upenn.edu

Publikováno v: Cells (2073-4409). Dec2023, Vol. 12 Issue 23, p2668. 29p.