Formin-mediated nuclear actin assembly at androgen receptors promotes transcriptional droplet formation

Autor: Julian Knerr, Ralf Werner, Carsten Schwan, Hong Wang, Peter Gebhardt, Helga Grötsch, Almuth Caliebe, Malte Spielmann, Paul-Martin Holterhus, Robert Grosse, Nadine Hornig

Steroid hormone receptors are ligand-binding transcription factors essential for mammalian physiology. The androgen receptor (AR) binds androgens mediating gene expression for sexual, somatic, and behavioral functions, and is involved in various cond

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a91d5032f23dbd127f2a3b360fa8032
https://doi.org/10.21203/rs.3.rs-1664650/v1

Reduced Androgen Receptor Expression in Genital Skin Fibroblasts From Patients With 45,X/46,XY Mosaicism

Autor: Paul-Martin Holterhus, Eva Maria Murga Penas, Olaf Hiort, Anne Katrin Eckstein, Almuth Caliebe, Pascal Rodens, Ralf Werner, Jeta Demiri, Hans-Udo Schweikert, Nadine Hornig, Alexandra Kulle, Ole Ammerpohl, Laura Audí

Publikováno v: The Journal of clinical endocrinology and metabolism. 104(10)

Context Molecular mechanisms causing the broad phenotypic diversity of external masculinization in individuals with 45,X/46,XY mosaicism are poorly understood. Objective Analysis of androgen receptor (AR) expression and function as a putative influen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10521c28a33eddd9a275ef03eeadda5d
https://pubmed.ncbi.nlm.nih.gov/31180485

Epigenetic Repression of Androgen Receptor Transcription in Mutation-Negative Androgen Insensitivity Syndrome (AIS Type II)

Autor: H. U. Schweikert, Olaf Hiort, Ole Ammerpohl, Susanne Bens, Hendrik G. Stunnenberg, Alexandra Kulle, Paul-Martin Holterhus, Nina C. Hubner, Ralf Werner, Anne Katrin Eckstein, Annemarie Verrijn-Stuart, Martine Cools, Helmuth G. Dörr, Susanne Gonzalves, Reiner Siebert, Nadine Hornig, Maik Welzel, Pascal Rodens

Publikováno v: The Journal of clinical endocrinology and metabolism, 103(12), 4617. The Endocrine Society
Journal of Clinical Endocrinology and Metabolism, 103, 12, pp. 4617-4627
Journal of Clinical Endocrinology and Metabolism, 103, 4617-4627

Contains fulltext : 197541.pdf (Publisher’s version ) (Closed access) Context: Inactivating mutations within the AR-gene are present in only around 40% of individuals with clinically and hormonally diagnosed androgen insensitivity syndrome (AIS). P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e58acb268e331df0c790daa943f487
https://dspace.library.uu.nl/handle/1874/373771

Multiples of Median-Transformed, Normalized Reference Ranges of Steroid Profiling Data Independent of Age, Sex, and Units

Autor: Thomas Reinehr, Marek Niedziela, Alexandra Kulle, Nadine Hornig, Christoph Borzikowsky, Paul-Martin Holterhus, Gunter Simic-Schleicher, Maciej Flader, Dominika Zalas, Halit Ilker Akkurt, Sabine Heger

Publikováno v: Hormone research in paediatrics. 89(4)

Background/Aims: The high complexity of pediatric reference ranges across age, sex, and units impairs clinical application and comparability of steroid hormone data, e.g., in congenital adrenal hyperplasia (CAH). We developed a multiples-of-median (M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::709e38342343f775e52b8253cdc3c98e
https://pubmed.ncbi.nlm.nih.gov/29694956

Determination of 17OHPreg and DHEAS by LC-MS/MS: Impact of Age, Sex, Pubertal Stage, and BMI on the Δ5 Steroid Pathway

Autor: Thomas Reinehr, Paul-Martin Holterhus, Alexandra Kulle, Nadine Hornig, Gunter Simic-Schleicher

Publikováno v: The Journal of clinical endocrinology and metabolism. 102(1)

Background: Dehydroepiandrosterone sulfate (DHEAS) and 17-hydroxypregnenolone (17OHPreg) are important for understanding the Δ5 pathway (e.g., in adrenarche and obesity). Although mass spectrometry has become the state-of-the-art method for quantify

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14c11ddd86f959ca0e76b531a9cafd25
https://pubmed.ncbi.nlm.nih.gov/27809697