Chronically Elevated Interleukin-6 Disturbs the Coagulation Cascade in Mice

Autor: Wolfram Ruf, Nadine Hoevelmeyer, Henri M. H. Spronk, Bernhard Lämmle, Tanja Knopp, Johannes Wild, Philip Wenzel, Thomas Wunderlich, Susanne Karbach, Thomas Münzel, Heidi Rossmann, Rebecca Jung, Jeremy Lagrange, Ari Waisman

Publikováno v: Blood. 138:2065-2065

Introduction: Pro-inflammatory cytokines play an essential role as activators of the hemostatic system and in the regulation of physiological antithrombotic mechanisms. Interleukin-6 (IL-6) influences platelet production and platelet activation. It w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2eb558a413d0e4149e2cfc5af5d1ebb3
https://doi.org/10.1182/blood-2021-149628

Thymus-derived regulatory T cells are positively selected on natural self-antigen through cognate interactions of high functional avidity

Autor: Stephen M. Anderton, Yarúa Jaimes, Roland S. Liblau, Nadine Hoevelmeyer, Ulrik Stervbo, Ping Shen, Uwe Klemm, Simon Fillatreau, Elisa Kieback, Vicky Lampropoulou, Wolfgang Uckert, Andreas Radbruch, M. Bunse, Ellen Hilgenberg, Pierre Boudinot, Anja A. Kühl

Publikováno v: Immunity
Immunity, Elsevier, 2016, 44 (5), pp.1114-1126. ⟨10.1016/j.immuni.2016.04.018⟩
Kieback, E, Hilgenberg, E, Stervbo, U, Lampropoulou, V, Shen, P, Bunse, M, Jaimes, Y, Boudinot, P, Radbruch, A, Klemm, U, Kühl, A A, Liblau, R, Hoevelmeyer, N, Anderton, S M, Uckert, W & Fillatreau, S 2016, ' Thymus-Derived Regulatory T Cells Are Positively Selected on Natural Self-Antigen through Cognate Interactions of High Functional Avidity ', Immunity, vol. 44, no. 5, pp. 1114-1126 . https://doi.org/10.1016/j.immuni.2016.04.018
Immunity, 2016, 44 (5), pp.1114-1126. ⟨10.1016/j.immuni.2016.04.018⟩

Regulatory T (Treg) cells expressing Foxp3 transcripton factor are essential for immune homeostasis. They arise in the thymus as a separate lineage from conventional CD4+Foxp3- T (Tconv) cells. Here, we show that the thymic development of Treg cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4be1af244f0664c13a2399fdc7cdd27
https://hal.inrae.fr/hal-02637633

Inhibitionof IL-1 signaling in hepatocytes retains insulin sensitivity and protects fromhepatocellular injury in nonalcoholic fatty liver disease

Autor: W. Marcus, JM Schattenberg, Ari Waisman, Detlef Schuppan, Beate K. Straub, Nadine Hoevelmeyer, N Gehrke, K.Y. Ook, PR Galle

Publikováno v: Journal of Hepatology. 68:S333

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b5c6d543caa015f75d267716db1d3794
https://doi.org/10.1016/s0168-8278(18)30884-5

The transcription factor Bcl-3 regulates the development of marginal zone, germinal center and B1 B cells (LYM7P.624)

Autor: Nadine Hoevelmeyer, Marcus Wörns, Sonja Reissig, Petra Adams-Quack, Ari Waisman

Publikováno v: The Journal of Immunology. 194:200.16-200.16

Bcl-3 is an atypical member of the IkB family and functions as a transcriptional suppressor or promoter by associating with the NF-kB members p50/NF-kB1 and p52/NF-kB2 homodimers. The bcl3 gene was first identified at the breaking point of recurring

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::06d6e4f7b53a89e56fa87232873f0ddc
https://doi.org/10.4049/jimmunol.194.supp.200.16

Combined B cell specific deletion of the deubiquitinating enzymes CYLD and A20 leads to a dramatic accumulation of CD5+ B cells (TUM5P.936)

Autor: Nadine Hoevelmeyer, Matthias Hahn, Ari Waisman

Publikováno v: The Journal of Immunology. 192:139.3-139.3

Mutations in NFκB signaling molecules and in negative regulators of NFκB, such as CYLD and A20, have been identified in B cell lymphomas. These deubiquitinating (DUB) enzymes remove activating lysine-63 linked ubiquitin chains from numerous NFκB s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd38f137aa9c527510b08f7fb16c263d
https://doi.org/10.4049/jimmunol.192.supp.139.3