Concerted regulation of ISWI by an autoinhibitory domain and the H4 N-terminal tail

Autor: Johanna Ludwigsen, Sabrina Pfennig, Ashish K Singh, Christina Schindler, Nadine Harrer, Ignasi Forné, Martin Zacharias, Felix Mueller-Planitz

Publikováno v: eLife, Vol 6 (2017)

ISWI-family nucleosome remodeling enzymes need the histone H4 N-terminal tail to mobilize nucleosomes. Here we mapped the H4-tail binding pocket of ISWI. Surprisingly the binding site was adjacent to but not overlapping with the docking site of an au

Externí odkaz: https://doaj.org/article/ff843e54053a417491a69848ba66e7b3

Structural Architecture of the Nucleosome Remodeler ISWI Determined from Cross-Linking, Mass Spectrometry, SAXS, and Modeling

Autor: Johanna Ludwigsen, Jan Lipfert, Nadine Harrer, Martin Zacharias, Linda K. Bruetzel, Felix Mueller-Planitz, Ignasi Forné, Christina E. M. Schindler, Axel Imhof

Publikováno v: Structure (London, England : 1993). 26(2)

Chromatin remodeling factors assume critical roles by regulating access to nucleosomal DNA. To determine the architecture of the Drosophila ISWI remodeling enzyme, we developed an integrative structural approach that combines protein cross-linking, m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::437913c18f34787abe7bd7e4a3457107
https://pubmed.ncbi.nlm.nih.gov/29395785

Auf der Suche nach dem 'idealen Beruf' für WirtschaftspädagogInnen mit Kind/ern

Autor: Nadine Harrer

Publikováno v: Vereinbarkeit von Beruf und familiären Sorgepflichten ISBN: 9783658145743

Das Wirtschaftspadagogikstudium ist mehrfach qualifizierend angelegt. AbsolventInnen konnen den Beruf einer Lehrkraft an berufsbildenden mittleren und hoheren Schulen, einer/eines Betriebspadagogin/-padagogen oder den einer/eines Expertin/Experten in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7dac1cf795135704a43168a7517bbe06
https://doi.org/10.1007/978-3-658-14575-0_8

A Poly-ADP-Ribose Trigger Releases the Auto-Inhibition of a Chromatin Remodeling Oncogene

Autor: Nadine Harrer, Sébastien Huet, Sebastian Eustermann, Ingvar R. Möller, Gunnar Knobloch, Markus Hassler, Hans A. V. Kistemaker, Kasper D. Rand, Christiane Kotthoff, Hari R. Singh, Charlotte Blessing, Aurelio Pio Nardozza, Felix Mueller-Planitz, Dmitri V. Filippov, Andreas G. Ladurner, Gyula Timinszky

Publikováno v: Molecular Cell
Molecular Cell, Elsevier, 2017, 68 (5), pp.860-871.e7. ⟨10.1016/j.molcel.2017.11.019⟩
Molecular Cell, 2017, 68 (5), pp.860-871.e7. ⟨10.1016/j.molcel.2017.11.019⟩
MOLECULAR CELL, 68(5), 860-871

DNA damage triggers chromatin remodeling by mechanisms that are poorly understood. The oncogene and chromatin remodeler ALC1/CHD1L massively decompacts chromatin in vivo yet is inactive prior to DNA-damage-mediated PARP1 induction. We show that the i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc80b6b90692759203bceac103c5fa2
https://doi.org/10.1016/j.molcel.2017.11.019

Integrative Modeling of the ISWI Chromatin Remodeling Enzyme from Cross-Linking/Mass Spectrometry and Saxs Data

Autor: Christina E. M. Schindler, Jan Lipfert, Felix Müller-Planitz, Nadine Harrer, Martin Zacharias

Publikováno v: ResearcherID

The eukaryotic genome is organized in the form of chromatin, a complex of DNA with compacting and regulatory proteins. The basic packing unit is the nucleosome where DNA is wrapped tightly around histone proteins. This packaging inevitably leads to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d60f929036e479d61a5bb4cda12630db
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000375141600156&KeyUID=WOS:000375141600156