Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Nadine Dobberstein"'
Autor:
Tobias Benkel, Mirjam Zimmermann, Julian Zeiner, Sergi Bravo, Nicole Merten, Victor Jun Yu Lim, Edda Sofie Fabienne Matthees, Julia Drube, Elke Miess-Tanneberg, Daniela Malan, Martyna Szpakowska, Stefania Monteleone, Jak Grimes, Zsombor Koszegi, Yann Lanoiselée, Shannon O’Brien, Nikoleta Pavlaki, Nadine Dobberstein, Asuka Inoue, Viacheslav Nikolaev, Davide Calebiro, Andy Chevigné, Philipp Sasse, Stefan Schulz, Carsten Hoffmann, Peter Kolb, Maria Waldhoer, Katharina Simon, Jesus Gomeza, Evi Kostenis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Abstract Carvedilol is among the most effective β-blockers for improving survival after myocardial infarction. Yet the mechanisms by which carvedilol achieves this superior clinical profile are still unclear. Beyond blockade of β1-adrenoceptors, ar
Externí odkaz:
https://doaj.org/article/31913551d70443ecbc6be0521f89476a
Autor:
Martin Soste, Dominique Kamber, Nadine Dobberstein, Mirjam Zimmermann, Aurelien Rizk, Yuehan Feng, Yaroslav Nikolaev, Nigel Beaton
Publikováno v:
Cancer Research. 83:3847-3847
In drug discovery, target identification (ID) after phenotypic screens is a resource-intensive endeavor aimed to understand compound’s mechanism of action. Target ID for membrane proteins is particularly challenging due to hurdles such as poor prot
Autor:
Bernd Bodenmiller, Denis Schapiro, Nadine Dobberstein, Vito R T Zanotelli, Marco Tognetti, James D Wade, Xiao-Kang Lun
Publikováno v:
Nature Biotechnology
Nature biotechnology
Nature biotechnology
Signaling networks are key regulators of cellular function. Although the concentrations of signaling proteins are perturbed in disease states, such as cancer, and are modulated by drug therapies, our understanding of how such changes shape the proper
Autor:
Attila Gábor, Bernd Bodenmiller, Julio Saez-Rodriguez, Xiao-Kang Lun, Christian von Mering, Damian Szklarczyk, Vito R T Zanotelli, Nadine Dobberstein
Publikováno v:
Molecular Cell, 74 (5)
Molecular Cell
Molecular cell 74(5), 1086-1102.e5 (2019). doi:10.1016/j.molcel.2019.04.021
Molecular Cell
Molecular cell 74(5), 1086-1102.e5 (2019). doi:10.1016/j.molcel.2019.04.021
Summary Kinase and phosphatase overexpression drives tumorigenesis and drug resistance. We previously developed a mass-cytometry-based single-cell proteomics approach that enables quantitative assessment of overexpression effects on cell signaling. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9830df187cade67403042e215a49e2cd
https://hdl.handle.net/20.500.11850/346503
https://hdl.handle.net/20.500.11850/346503
Autor:
Damian Szklarczyk, Bernd Bodenmiller, Vito R T Zanotelli, von Mering C, Attila Gábor, Julio Saez-Rodriguez, Xiao-Kang Lun, Nadine Dobberstein
Kinase and phosphatase overexpression drives tumorigenesis and drug resistance in many cancer types. Signaling networks reprogrammed by protein overexpression remain largely uncharacterized, hindering discovery of paths to therapeutic intervention. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7a9eb2042507f16e0ee0e9e9cb0a0ea
https://doi.org/10.1101/314716
https://doi.org/10.1101/314716