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Nasopharyngeal colonization withStreptococcus pneumoniaetriggers dendritic cell dependent antibody responses against invasive disease in mice

Autor: Anne Dommaschk, Tobias Welte, Peter Braubach, Torsten Lippmann, Regina Maus, Jennifer Stolper, Lara Friederike Bittersohl, Meritxell Tort Tarrés, Nadine Ding, Ulrich A. Maus, Danny Jonigk

Publikováno v: European Journal of Immunology. 47:540-551

Nasopharyngeal colonization with Streptococcus pneumoniae (Spn) is an important precondition for the development of pneumococcal pneumonia. At the same time, nasopharyngeal colonization with Spn has been shown to mount adaptive immune responses again

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf572f8fc080d3f0d6f34957edbb0ca7
https://doi.org/10.1002/eji.201646700

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Impact of nasopharyngeal pneumococcal colonization on dendritic cell-dependent protective immunity against invasive pneumococcal disease in mice

Autor: Anne Dommaschk, Tobias Welte, Nadine Ding, Lara Friederike Bittersohl, Gabriele Kirchhof, Ulrich A. Maus

Publikováno v: 10.1 Respiratory Infections.

Nasopharyngeal colonization with Streptococcus pneumoniae (Spn) is an essential precondition to develop pneumococcal pneumonia. At the same time, it has also been shown to mount adaptive immune responses against Spn in mice and humans. Until now, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b35889014f73ef72796cf3a2f4fded1e
https://doi.org/10.1183/13993003.congress-2016.pa2592

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Role of p38 mitogen-activated protein kinase in posttraumatic immunosuppression in mice

Autor: Katja Dahlke, Nadine Ding, Ann-Kathrin Janze, Regina Maus, Jennifer Bohling, Ulrich A. Maus, Michael Bauer, Petra C. Mailer, Niels C. Riedemann, Tobias Welte

Publikováno v: Journal of Trauma and Acute Care Surgery. 73:861-868

BACKGROUND: Patients with multiple injuries surviving the initial insult are highly susceptible to secondary pneumonia, frequently progressing into sepsis and multiorgan failure. However, the underlying mechanisms of posttraumatic immunosuppression a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13c5c0761c67f84859f43b5ba5f86a9c
https://doi.org/10.1097/ta.0b013e31825ab11f

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Importance of CXC Chemokine Receptor 2 in Alveolar Neutrophil and Exudate Macrophage Recruitment in Response to Pneumococcal Lung Infection

Autor: David E. Briles, Ulrich A. Maus, Regina Maus, Jörg Reutershan, Matthias Mack, James C. Paton, Ines Hahn, Wiebke Herbold, Tobias Welte, John W. Christman, Mrigank Srivastava, Christine C. Winter, Nadine Ding

Publikováno v: Infection and Immunity. 78:2620-2630

Sustained neutrophilic infiltration is known to contribute to organ damage, such as acute lung injury. CXC chemokine receptor 2 (CXCR2) is the major receptor regulating inflammatory neutrophil recruitment in acute and chronic inflamed tissues. Whethe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c73f4fab42b60ae5753905f092823d
https://doi.org/10.1128/iai.01169-09

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Mice That Overexpress CC Chemokine Ligand 2 in Their Lungs Show Increased Protective Immunity to Infection withMycobacterium bovisBacille Calmette‐Guérin

Autor: Nadine Ding, Ulrich A. Maus, Jana Prokein, Florian Länger, Tobias Welte, Michael D. Gunn, Regina Maus, Mrigank Srivastava, Olivia Schreiber, Kathrin Steinwede, Stefan Ehlers

Publikováno v: The Journal of Infectious Diseases. 198:1044-1054

Background. The acute phase of mycobacterial lung infection is characterized by a nearly exponential outgrowth of mycobacteria in the alveolar airspace and lung parenchymal tissue, suggesting insufficient early protective immunity against mycobacteri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e79ffa3b93b3d7d30d391ac99cc26ff
https://doi.org/10.1086/591501

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Impact of nasopharyngeal pneumococcal colonization on protective immunity againstS. pneumoniaein mice

Autor: Anne Dommaschk, Ulrich A. Maus, Lara Friederike Bittersohl, Gabriele Kirchhof, Nadine Ding, Tobias Welte

Publikováno v: 10.1 Respiratory Infections.

Nasopharyngeal colonization with S. pneumoniae (Spn) has been shown to mount adaptive immune responses against Spn in mice and humans. However, the cellular response of the nasopharyngeal compartment, including the nasal-associated lymphoreticular ti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e63cde2ccac0c7706417a756079bd2b6
https://doi.org/10.1183/13993003.congress-2015.pa5042

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Streptococcus pneumoniae triggers progression of pulmonary fibrosis through pneumolysin

Publikováno v: Thorax. 70(7)

Rationale: Respiratory tract infections are common in patients suffering from pulmonary fibrosis. The interplay between bacterial infection and fibrosis is poorly characterized. It is still unclear whether bacterial infections in IPF are merely a sec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b38b060e5f14b03a19d3093aba2cd5b9
https://pubmed.ncbi.nlm.nih.gov/25964315

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Basophil expansion protects against invasive pneumococcal disease in mice

Autor: Christina Brumshagen, Andrea Bischof, Tobias Welte, Matthias Mack, David E. Briles, Johannes Engelbert Gessner, Nadine Ding, Gabriele Kirchhof, Ulrich A. Maus

Publikováno v: The Journal of infectious diseases. 210(1)

Background Protein-based vaccination using pneumococcal proteins is a promising approach for efficient vaccines against Streptococcus pneumoniae. Basophils play an important role in enhancing memory immune responses to intact proteins. We examined th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::292e19fe569a6c64fe0cf1b7c5368c8a
https://pubmed.ncbi.nlm.nih.gov/24470504

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