Výsledky vyhledávání - "Nadine Davelaar"

Akademický článek

Characterizing memory T helper cells in patients with psoriasis, subclinical, or early psoriatic arthritis using a machine learning algorithm

Autor: Hannah den Braanker, Wida Razawy, Kim Wervers, Anne-Marie C. Mus, Nadine Davelaar, Marc R. Kok, Erik Lubberts

Publikováno v: Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-11 (2022)

Abstract Background Psoriasis patients developing psoriatic arthritis (PsA) are thought to go through different phases. Understanding the underlying events in these phases is crucial to diagnose PsA early. Here, we have characterized the circulating

Externí odkaz: https://doaj.org/article/b5b109e680964125814cb04fe51be791

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Akademický článek

The heterogeneous human memory CCR6+ T helper-17 populations differ in T-bet and cytokine expression but all activate synovial fibroblasts in an IFNγ-independent manner

Autor: Wendy Dankers, Hannah den Braanker, Sandra M. J. Paulissen, Jan Piet van Hamburg, Nadine Davelaar, Edgar M. Colin, Erik Lubberts

Publikováno v: Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-14 (2021)

Abstract Background Chronic synovial inflammation is an important hallmark of inflammatory arthritis, but the cells and mechanisms involved are incompletely understood. Previously, we have shown that CCR6+ memory T-helper (memTh) cells and synovial f

Externí odkaz: https://doaj.org/article/526263f0e7cc4401a91b7282c617800f

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Akademický článek

Achieving sustained minimal disease activity with methotrexate in early interleukin 23-driven early psoriatic arthritis

Autor: Ilja Tchetverikov, J M W Hazes, Hannah den Braanker, Kim Wervers, Adriana M C Mus, Priyanka S Bangoer, Nadine Davelaar, Jolanda Luime, Marijn Vis, Erik Lubberts, Marc R Kok

Publikováno v: RMD Open, Vol 6, Iss 2 (2020)

Objectives Methotrexate (MTX) is currently the recommended first-line therapy for treating psoriatic arthritis (PsA), despite lacking clear evidence. No estimates of efficacy of MTX in usual care and no clear MTX responsive clinical or laboratory var

Externí odkaz: https://doaj.org/article/24b4e5d985e5401e84ecc24f39c6a671

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Akademický článek

1,25(OH)2D3 and dexamethasone additively suppress synovial fibroblast activation by CCR6+ T helper memory cells and enhance the effect of tumor necrosis factor alpha blockade

Autor: Wendy Dankers, Claudia González-Leal, Nadine Davelaar, Patrick S. Asmawidjaja, Adriana M. C. Mus, Johanna M. W. Hazes, Edgar M. Colin, Erik Lubberts

Publikováno v: Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-10 (2018)

Abstract Background Despite recent improvements in the treatment of rheumatoid arthritis (RA), an insufficient treatment response and the development of treatment resistance in many patients illustrates the need for new therapeutic strategies. Chroni

Externí odkaz: https://doaj.org/article/3a07dc2ca00a40bcbb47638e4912b65b

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Akademický článek

Human Memory Th17 Cell Populations Change Into Anti-inflammatory Cells With Regulatory Capacity Upon Exposure to Active Vitamin D

Autor: Wendy Dankers, Nadine Davelaar, Jan Piet van Hamburg, Jeroen van de Peppel, Edgar M. Colin, Erik Lubberts

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Autoimmune diseases are characterized by an aberrantly activated immune system, resulting in tissue damage and functional disability in patients. An important therapeutic goal is to restore the deregulated immunological balance between pro- and anti-

Externí odkaz: https://doaj.org/article/800b6073609f40459725de63c2f3f8be

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Discovery of small-molecules targeting the CCL20/CCR6 axis as first-in-class inhibitors for inflammatory bowel diseases

Autor: Maria Grazia Martina, Carmine Giorgio, Marika Allodi, Simone Palese, Elisabetta Barocelli, Vigilio Ballabeni, Martyna Szpakowska, Andy Chevigné, Jan Piet van Hamburg, Nadine Davelaar, Erik Lubberts, Simona Bertoni, Marco Radi

Publikováno v: European Journal of Medicinal Chemistry, 243:114703. Elsevier Masson

The CCL20/CCR6 axis is implicated in the migration of CCR6+ immune cells towards CCL20, its sole ligand, whose expression is increased during inflammatory processes and is known to play a pivotal role in triggering different autoimmune-mediated infla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba00cdd7a8f3511eb54cb95d8f4337e
https://doi.org/10.1016/j.ejmech.2022.114703

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Interleukin-17A Is Produced by CD4+ but Not CD8+ T Cells in Synovial Fluid Following T Cell Receptor Activation and Regulates Different Inflammatory Mediators Compared to Tumor Necrosis Factor in a Model of Psoriatic Arthritis Synovitis

Autor: Dominique Baeten, Patrick S. Asmawidjaja, Johanna M. W. Hazes, R Bisoendial, X Xu, Erik Lubberts, Anne-Marie Mus, Errol P. Prens, Nadine Davelaar, Marijn Vis

Publikováno v: Arthritis & Rheumatology (Hoboken, N.j.)
Arthritis & rheumatology (Hoboken, N.J.), 72(8), 1303-1313. John Wiley and Sons Ltd
Arthritis and Rheumatology, 72(8), 1303-1313. John Wiley & Sons Ltd.

Objective: Interleukin-17A (IL-17A) and tumor necrosis factor (TNF) contribute to the pathogenesis of psoriatic arthritis (PsA). However, their functional relationship in PsA synovitis has not been fully elucidated. Additionally, although CD8+ T cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd90ea574eafee4f02f40b79cf3a766
http://www.scopus.com/inward/record.url?scp=85087625133&partnerID=8YFLogxK

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The heterogeneous human memory CCR6+ T helper-17 populations differ in T-bet and cytokine expression but all activate synovial fibroblasts in an IFNγ-independent manner

Autor: Hannah den Braanker, Jan Piet van Hamburg, Wendy Dankers, Erik Lubberts, Nadine Davelaar, Sandra M. J. Paulissen, E. M. Colin

Publikováno v: Arthritis Research & Therapy
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-14 (2021)
Arthritis research & therapy, 23(1):157. BioMed Central
Arthritis Research and Therapy, 23(1):157. BioMed Central Ltd.

Background Chronic synovial inflammation is an important hallmark of inflammatory arthritis, but the cells and mechanisms involved are incompletely understood. Previously, we have shown that CCR6+ memory T-helper (memTh) cells and synovial fibroblast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::795f7dc24a0cf3004bc454e0fdadf116
http://www.scopus.com/inward/record.url?scp=85107112014&partnerID=8YFLogxK

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CD4 + CCR6 + T cells, but not γδ T cells, are important for the IL‐23R‐dependent progression of antigen‐induced inflammatory arthritis in mice

Autor: Anne-Marie Mus, Wida Razawy, Erik Lubberts, Nicole Kops, Celso H. Alves, Nadine Davelaar, Nazike Salioska, Patrick S. Asmawidjaja, Mohamed Oukka

Publikováno v: European Journal of Immunology
European Journal of Immunology, 50, 245-255. Wiley-VCH

IL-23 plays an important role in the development of arthritis and the IL-23 receptor (IL-23R) is expressed on different types of T cells. However, it is not fully clear which IL-23R+ T cells are critical in driving T cell-mediated synovitis. We demon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c94b6f3d2c96705cdedbe6c1fe2beee
https://doi.org/10.1002/eji.201948112

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Apremilast for moderate hidradenitis suppurativa: no significant change in lesional skin inflammatory biomarkers

Autor: Adriana M.C. Mus, Allard R. J. V. Vossen, Errol P. Prens, M.B.A. van Doorn, Nadine Davelaar, H.H. van der Zee

Publikováno v: Journal of the Academy of Dermatology and Venereology, 33(4), 761-765. Wiley-Blackwell
Journal of the European Academy of Dermatology and Venereology

Background Treatment with apremilast has recently demonstrated clinically meaningful improvement in moderate hidradenitis suppurativa (HS). Objective To evaluate the change in expression of inflammatory markers in lesional skin of HS patients receivi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65dd97232b37bafdfb4678beaa725063
https://hdl.handle.net/1765/113080

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