Výsledky vyhledávání - "Nadine Clerc"

Diverse roles and modulations of IA in spinal cord pain circuits

Autor: Nadine Clerc, Aziz Moqrich

Publikováno v: Cell Reports
Cell Reports, 2022, 38 (13), pp.110588. ⟨10.1016/j.celrep.2022.110588⟩

International audience; Abstract Patients with bi-allelic loss of function mutations in the voltage-gated sodium channel Nav1.7 present with congenital insensitivity to pain (CIP), whilst low threshold mechanosensation is reportedly normal. Using psy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3357a4b43610c9e6f6e3d9bc978c951
https://cnrs.hal.science/hal-03871086

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Diverse roles and modulations of I

Autor: Nadine, Clerc, Aziz, Moqrich

Publikováno v: Cell reports. 38(13)

This review highlights recent findings of different amplitude ranges, roles, and modulations of A-type K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a1e7f540a96a400498aa3bac7997c400
https://pubmed.ncbi.nlm.nih.gov/35354022

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TAFA4 relieves injury-induced mechanical hypersensitivity through LDL receptors and modulation of spinal A-type K+ current

Autor: Catarina Santos, Rafaelle Rossignol, Ana Reynders, Jean-Yves Springael, Pascale Malapert, Irène Marics, Francis Castets, Marc Parmentier, Andrew J. Saurin, Aziz Moqrich, Sophie Ugolini, Nadine Clerc, Jean-Marc Goaillard, Sungjae Yoo, Abderazzak El Khallouqi, Aude Charron, Stéphane Gaillard

Publikováno v: Cell Reports
Cell Reports, 2021, 37 (4), pp.109884. ⟨10.1016/j.celrep.2021.109884⟩
Cell Reports, Elsevier Inc, 2021, 37 (4), pp.109884. ⟨10.1016/j.celrep.2021.109884⟩

Pain, whether acute or persistent, is a serious medical problem worldwide. However, its management remains unsatisfactory, and new analgesic molecules are required. We show here that TAFA4 reverses inflammatory, postoperative, and spared nerve injury

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78e722239cd59751b7510795b8b93fcf
https://doi.org/10.1016/j.celrep.2021.109884

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Kv4 channels underlie A-currents with highly variable inactivation time courses but homogeneous other gating properties in the nucleus tractus solitarii

Autor: Fabien Tell, Estelle Moubarak, Virginie Penalba, Layal Saliba, Nadine Clerc, Caroline Strube, Marie-France Martin-Eauclaire

Publikováno v: Pflügers Archiv European Journal of Physiology
Pflügers Archiv European Journal of Physiology, Springer Verlag, 2015, 467 (4), pp.789-803. ⟨10.1007/s00424-014-1533-z⟩
Pflügers Archiv European Journal of Physiology, 2015, 467 (4), pp.789-803. ⟨10.1007/s00424-014-1533-z⟩

In the nucleus of the tractus solitarii (NTS), a large proportion of neurones express transient A-type potassium currents (I KA) having deep influence on the fidelity of the synaptic transmission of the visceral primary afferent inputs to second-orde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bacd138cc8e833ea216dce9f0b1f6be3
https://doi.org/10.1007/s00424-014-1533-z

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Ankyrin G membrane partners drive the establishment and maintenance of the axon initial segment

Autor: Fanny Rueda-Boroni, Christophe Leterrier, Nadine Clerc, Audrey Montersino, Bénédicte Dargent, Francis Castets

Publikováno v: Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience, 2017, 11, pp.6. ⟨10.3389/fncel.2017.00006⟩
Frontiers in Cellular Neuroscience, Frontiers, 2017, 11, pp.6. ⟨10.3389/fncel.2017.00006⟩

International audience; The axon initial segment (AIS) is a highly specialized neuronal compartment that plays a key role in neuronal development and excitability. It concentrates multiple membrane proteins such as ion channels and cell adhesion mole

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc69d9621459ad7a4732fb546a057771
https://doi.org/10.1101/073163

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Activation of neurokinin 3 receptor increases Nav1.9 current in enteric neurons

Autor: Maurice Gola, Nadine Clerc, Patrick Delmas, Carine Copel, Marcel Crest, Nancy Osorio

Publikováno v: The Journal of Physiology. 587:1461-1479

The intrinsic primary afferent neurons (IPANs) of the guinea pig enteric nervous system express Na(v)1.9 sodium channels that produce a persistent TTX-resistant current having a low activation threshold and slow gating kinetics. These neurons receive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e40713436f8f468a581a0ffbf019410f
https://doi.org/10.1113/jphysiol.2009.169409

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Expression and localization of the Nav1.9 sodium channel in enteric neurons and in trigeminal sensory endings: Implication for intestinal reflex function and orofacial pain

Autor: Bertrand Coste, François Maingret, Marcel Crest, Henry Magloire, Patrick Delmas, Amy M. Ritter, Françoise Padilla, Nadine Clerc, Marie-Lise Couble

Publikováno v: Molecular and Cellular Neuroscience
Molecular and Cellular Neuroscience, 2007, 35 (1), pp.138-52. ⟨10.1016/j.mcn.2007.02.008⟩

The Nav1.9 sodium channel is expressed in nociceptive DRG neurons where it contributes to spontaneous pain behavior after peripheral inflammation. Here, we used a newly developed antibody to investigate the distribution of Nav1.9 in rat and mouse tri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68cc5bedee5f552bf37b50e22e8d6085
https://doi.org/10.1016/j.mcn.2007.02.008

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Intrinsic primary afferent neurones of the digestive tract

Autor: Nadine Clerc, John B. Furness

Publikováno v: Neurogastroenterology and Motility. 16:24-27

Intrinsic primary afferent neurones of the intestine are specialized neurones that encode information about the state of the intestine by transducing mechanical and chemical stimuli that reflect tension in the gut wall and the chemical nature of its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d31a78990aefee51a31b1c76b617bbe
https://doi.org/10.1111/j.1743-3150.2004.00470.x

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Intrinsic primary afferent neurons and nerve circuits within the intestine

Autor: Clare A. Jones, Kulmira Nurgali, John B. Furness, Nadine Clerc

Publikováno v: Progress in Neurobiology. 72:143-164

Intrinsic primary afferent neurons (IPANs) of the enteric nervous system are quite different from all other peripheral neurons. The IPANs are transducers of physiological stimuli, including movement of the villi or distortion of the mucosa, contracti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8912996dbb24cc5e61e7da70c1b2352b
https://doi.org/10.1016/j.pneurobio.2003.12.004

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Comparison of the effects of phorbol dibutyrate and low-frequency stimulation of synaptic inputs on the excitability of myenteric AH neurons

Autor: Nadine Clerc, Martin J. Stebbing, Trung V. Nguyen, Mitsuhisa Kawai, John B. Furness, Seiichi Komori

Publikováno v: Pfl�gers Archiv European Journal of Physiology. 447:298-304

Low-frequency stimulation of synaptic inputs to after-hyperpolarising (AH) neurons in the guinea-pig small intestine causes sustained increases in excitability that far outlast the stimulus period. This excitation has been called sustained, slow, pos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca9bd83f2cfa01e766d462f0408f3bb
https://doi.org/10.1007/s00424-003-1179-8

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