Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Nadine Brehm"'
Autor:
Suna Lahut, Suzana Gispert, Özgür Ömür, Candan Depboylu, Kay Seidel, Jorge Antolio Domínguez-Bautista, Nadine Brehm, Hülya Tireli, Karl Hackmann, Caroline Pirkevi, Barbara Leube, Vincent Ries, Kerstin Reim, Nils Brose, Wilfred F. den Dunnen, Madrid Johnson, Zsuzsanna Wolf, Marc Schindewolf, Wiebke Schrempf, Kathrin Reetz, Peter Young, David Vadasz, Achilleas S. Frangakis, Evelin Schröck, Helmuth Steinmetz, Marina Jendrach, Udo Rüb, Ayşe Nazlı Başak, Wolfgang Oertel, Georg Auburger
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 5, Pp 619-631 (2017)
Parkinson's disease (PD) is a frequent neurodegenerative process in old age. Accumulation and aggregation of the lipid-binding SNARE complex component α-synuclein (SNCA) underlies this vulnerability and defines stages of disease progression. Determi
Externí odkaz:
https://doaj.org/article/f247356cd98c40f2b0349f1591cc83ae
Publikováno v:
Parkinson's Disease, Vol 2016 (2016)
Hereditary Parkinson’s disease can be triggered by an autosomal dominant overdose of alpha-Synuclein (SNCA) or the autosomal recessive deficiency of PINK1. We recently showed that the combination of PINK1-knockout with overexpression of A53T-SNCA i
Externí odkaz:
https://doaj.org/article/4a2567dc18e74c7a92f9b83ab9ffc0d7
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 471:1065-1078
Senescent cells, which are cells in a post-proliferative state, show an increased number of dysfunctional mitochondria and oxidatively damaged and aggregated proteins. The mitochondrial-lysosomal axis theory of aging proposes that the autophago-lysos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f15f1e311d9a0ba16d03bf46abfbc6a8
https://doi.org/10.1007/s00424-019-02288-x
https://doi.org/10.1007/s00424-019-02288-x
Publikováno v:
28th Annual European Real Estate Society Conference.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c13c74a9e7e1c1fb5600514a2e99fdfb
https://doi.org/10.15396/eres2021_166
https://doi.org/10.15396/eres2021_166
Publikováno v:
Zeitschrift für wirtschaftlichen Fabrikbetrieb. 112:843-847
Kurzfassung Die hohe Komplexität in Organisation und Technik sowie der Abbau von Zeit- und Bestandspuffern im Rahmen einer schlanken Produktion führen zu einer steigenden Störanfälligkeit der betrieblichen Abläufe. Eine vollkommene Prozessstabil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bbe32e3723270a973648d060d5b80b9
https://doi.org/10.3139/104.111840
https://doi.org/10.3139/104.111840
Autor:
Nadine Brehm, Peter Ohlhausen, Dennis Euper, Arthur Tomm, Daban Ahmad, Diana Mehl, Sebastian Schlund, Bastian Pokorni, Stefanie Findeisen, Daniel Palm
Publikováno v:
Zeitschrift für wirtschaftlichen Fabrikbetrieb. 112:20-24
Kurzfassung Angesichts des breiten Angebotsspektrums neuer Technologien und der Vielzahl verschieden verwendeter Begriffe rund um Industrie 4.0, stehen Unternehmen nicht selten orientierungslos vor der Herausforderung, individuelle Umsetzungsstrategi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc17350bcf2311e4fabbe85ce9f4687c
https://doi.org/10.3139/104.111662
https://doi.org/10.3139/104.111662
Autor:
Suzana Gispert, Marina Jendrach, Georg Auburger, Jana Key, Sylvia Torres-Odio, Nesli-Ece Sen, Nadine Brehm, Júlia Canet-Pons
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 13, p 3284 (2019)
International Journal of Molecular Sciences
Volume 20
Issue 13
International Journal of Molecular Sciences
Volume 20
Issue 13
Hereditary Parkinson&rsquo
s disease (PD) can be triggered by an autosomal dominant overdose of alpha-Synuclein (SNCA) as stressor or the autosomal recessive deficiency of PINK1 Serine/Threonine-phosphorylation activity as stress-response. We de
s disease (PD) can be triggered by an autosomal dominant overdose of alpha-Synuclein (SNCA) as stressor or the autosomal recessive deficiency of PINK1 Serine/Threonine-phosphorylation activity as stress-response. We de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c814482c846251ef8f6fc21f0d2c0e9
Autor:
Hülya Tireli, Marc Schindewolf, Özgür Ömür, Georg Auburger, Ayşe Nazlı Başak, Wilfred F. A. den Dunnen, Nadine Brehm, Candan Depboylu, David Vadasz, Helmuth Steinmetz, Vincent Ries, Achilleas S. Frangakis, Kerstin Reim, Caroline Pirkevi, Zsuzsanna Wolf, Jorge Antolio Dominguez-Bautista, Madrid Johnson, Nils Brose, Peter Young, Suzana Gispert, Marina Jendrach, Kay Seidel, Evelin Schröck, Kathrin Reetz, Wiebke Schrempf, Wolfgang H. Oertel, Udo Rüb, Barbara Leube, Suna Lahut, Karl Hackmann
Publikováno v:
Disease models and mechanisms
Parkinson's disease (PD) is a frequent neurodegenerative process in old age. Accumulation and aggregation of the lipid-binding SNARE complex component α-synuclein (SNCA) underlies this vulnerability and defines stages of disease progression. Determi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6d6d359d653032050e1f0418e829e79
https://hdl.handle.net/11858/00-001M-0000-002D-7056-611858/00-001M-0000-002D-7054-A
https://hdl.handle.net/11858/00-001M-0000-002D-7056-611858/00-001M-0000-002D-7054-A
Autor:
Rainer Landgraf, Ulrike Schmidt, Beat Lutz, Florian Holsboer, Patrick O. Markt, Tobias Mattheus, Stella Iurato, Elisabeth B. Binder, L. Czibere, Nadine Brehm, Rebekka P. Diepold, Andrea Bultmann, Angelika Erhardt, S. V. Sotnikov, Roshan R. Naik
Publikováno v:
Translational Psychiatry, Vol 8, Iss 1, Pp 1-18 (2018)
TRANSLATIONAL PSYCHIATRY
Translational Psychiatry
TRANSLATIONAL PSYCHIATRY
Translational Psychiatry
TMEM132D is a candidate gene, where risk genotypes have been associated with anxiety severity along with higher mRNA expression in the frontal cortex of panic disorder patients. Concurrently, in a high (HAB) and low (LAB) trait anxiety mouse model, T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dffad9a83768eef1af96598666336f0d
https://hdl.handle.net/10356/86287
https://hdl.handle.net/10356/86287
Autor:
Nadine Brehm, Georg Auburger, T. Carlsson, Beatrice Kern, Francesco Bez, Suzana Gispert, M. A. Cenci
Publikováno v:
Molecular Neurobiology. 52:1152-1164
Alpha-synuclein (SNCA) protein aggregation plays a causal role in Parkinson's disease (PD). The SNCA protein modulates neurotransmission via the SNAP receptor (SNARE) complex assembly and presynaptic vesicle trafficking. The striatal presynaptic dopa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c092a3825e5bae727b88670176259f6f
https://doi.org/10.1007/s12035-014-8911-6
https://doi.org/10.1007/s12035-014-8911-6