Serum and Soleus Metabolomics Signature of Klf10 Knockout Mice to Identify Potential Biomarkers

Autor: Nadine Baroukh, Nathan Canteleux, Antoine Lefèvre, Camille Dupuy, Cécile Martias, Antoine Presset, Malayannan Subramaniam, John R. Hawse, Patrick Emond, Philippe Pouletaut, Sandrine Morandat, Sabine F. Bensamoun, Lydie Nadal-Desbarats

Publikováno v: Metabolites, Vol 12, Iss 6, p 556 (2022)

The transcription factor Krüppel-like factor 10 (Klf10), also known as Tieg1 for TGFβ (Inducible Early Gene-1) is known to control numerous genes in many cell types that are involved in various key biological processes (differentiation, proliferati

Externí odkaz: https://doaj.org/article/df3452c8521d491aae4c8884357bf112

Optimization of Sample Preparation for Metabolomics Exploration of Urine, Feces, Blood and Saliva in Humans Using Combined NMR and UHPLC-HRMS Platforms

Autor: Cécile Martias, Nadine Baroukh, Sylvie Mavel, Hélène Blasco, Antoine Lefèvre, Léa Roch, Frédéric Montigny, Julie Gatien, Laurent Schibler, Diane Dufour-Rainfray, Lydie Nadal-Desbarats, Patrick Emond

Publikováno v: Molecules, Vol 26, Iss 14, p 4111 (2021)

Currently, most clinical studies in metabolomics only consider a single type of sample such as urine, plasma, or feces and use a single analytical platform, either NMR or MS. Although some studies have already investigated metabolomics data from mult

Externí odkaz: https://doaj.org/article/3a270acea1814406b6d6d4895539ead4

Panitumumab and cetuximab affect differently miRNA expression in colorectal cancer cells

Autor: Sajida Ibrahim, Gilles Paintaud, Laetitia Corset, Maxime Guéguinou, Céline Desvignes, Romain Chautard, William Raoul, Nadine Baroukh, Thierry Lecomte

Publikováno v: Biomarkers in Medicine
Biomarkers in Medicine, Future Medicine, 2021, Online ahead of print. ⟨10.2217/bmm-2020-0520⟩
Biomarkers in Medicine, 2021, Online ahead of print. ⟨10.2217/bmm-2020-0520⟩

International audience; Structured abstract Background & aim: Resistance to anti-EGFR monoclonal antibodies in metastatic colorectal cancer (CRC) is frequent and prognostic biomarkers are lacking. MicroRNAs (miR) are good candidates in this context.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::362055362c36a043cfa89401fe0e327f
https://www.hal.inserm.fr/inserm-03272360

Function of microRNA-375 and microRNA-124a in pancreas and brain

Autor: Nadine Baroukh, Emmanuel Van Obberghen

Publikováno v: FEBS Journal. 276:6509-6521

In recent years, our understanding of how gene regulatory networks control cell physiology has improved dramatically. Studies have demonstrated that transcription is regulated not only by protein factors, but also by small RNA molecules, microRNAs (m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::585787a32436df2b338a91d7c3c3822f
https://doi.org/10.1111/j.1742-4658.2009.07353.x

IgG1 Allotypes Influence the Pharmacokinetics of Therapeutic Monoclonal Antibodies through FcRn Binding

Autor: David Ternant, Christophe Passot, Christine Dhommée, Gilles Paintaud, Gérard Tiraby, Christophe Arnoult, Valérie Gouilleux-Gruart, Daniel Drocourt, Nadine Baroukh, Eric Perouzel, Hervé Watier, Martine Pugnière, Denis Mulleman

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2016, 196 (2), pp.607-613. ⟨10.4049/jimmunol.1501780⟩

Because IgG1 allotypes might have different half-lives, their influence on infliximab (G1m17,1 allotype) pharmacokinetics was investigated in a group of spondyloarthritis patients. Infliximab was found to have a shorter half-life in patients homozygo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b11a1768d70c899e5f0737fe172318
https://pubmed.ncbi.nlm.nih.gov/26685205