Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Nadine Bakkar"'
Autor:
Nadine Bakkar, Alexander Starr, Benjamin E. Rabichow, Ileana Lorenzini, Zachary T. McEachin, Robert Kraft, Matthew Chaung, Sam Macklin-Isquierdo, Taylor Wingfield, Briggs Carhart, Nathan Zahler, Wen-Hsuan Chang, Gary J. Bassell, Alexandre Betourne, Nicholas Boulis, Samuel V. Alworth, Justin K. Ichida, Paul R. August, Daniela C. Zarnescu, Rita Sattler, Robert Bowser
Publikováno v:
Neurobiology of Disease, Vol 149, Iss , Pp 105228- (2021)
Disruption in copper homeostasis causes a number of cognitive and motor deficits. Wilson's disease and Menkes disease are neurodevelopmental disorders resulting from mutations in the copper transporters ATP7A and ATP7B, with ATP7A mutations also caus
Externí odkaz:
https://doaj.org/article/9e65354b9c964af3a16790973ddace6f
Autor:
Jennifer M. Peterson, David J. Wang, Vikram Shettigar, Steve R. Roof, Benjamin D. Canan, Nadine Bakkar, Jonathan Shintaku, Jin-Mo Gu, Sean C. Little, Nivedita M. Ratnam, Priya Londhe, Leina Lu, Christopher E. Gaw, Jennifer M. Petrosino, Sandya Liyanarachchi, Huating Wang, Paul M. L. Janssen, Jonathan P. Davis, Mark T. Ziolo, Sudarshana M. Sharma, Denis C. Guttridge
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
The molecular mechanisms leading to heart failure in patients with Duchenne muscular dystrophy are unclear. Here the authors show that NF-κB is activated in the heart of dystrophin-deficient mice and that its ablation rescues cardiac function throug
Externí odkaz:
https://doaj.org/article/aa724b3e4c7b4ada9b67a708841b1195
Autor:
Kateřina Sheardová, Gustavo Sevlever, Victoria David-Dirgo, Marian Hajduch, Patrick Pirrotte, Clara Limbäck-Stokin, Ritin Sharma, Durga Jha, Robert A. Rissman, Lucia Pertierra, Maria Carna, Richard A. G. Smith, Petr Kaňovsky, Nadine Bakkar, Valentina Lacovich, Hana Markova, Mojmir Vinkler, Giancarlo Forte, Jiri Damborsky, Jan Fric, Silvie Belaskova, Krystine Garcia-Mansfield, Hernan Chaves, Eric B. Dammer, Marketa Nezvedova, Ruben Houbrechts, Gorazd B. Stokin, Nicholas T. Seyfried, Robert Bowser, Martin Vyhnalek, Zuzana Nedelska, Stanislav Katina, Kateřina Texlova, Jan Laczó, Isaac G. Onyango, Thijs Vande Vyvere, Dusan Holub, Zdenek Spacil, Jakub Hort
Publikováno v:
Alzheimer´s & Dementia
Alzheimer’s disease is a neurodegenerative disorder characterized clinically by cognitive decline and pathologically by amyloid deposition and neurofibrillary changes. These neuropathological hallmarks are accompanied by reactive events including m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0876e506d5055bb9da0913d0998881ad
https://doi.org/10.1002/alz.12970
https://doi.org/10.1002/alz.12970
Autor:
Briggs Carhart, Matthew Chaung, Taylor Wingfield, Sam Macklin-Isquierdo, Gary J. Bassell, Alexander Starr, Ileana Lorenzini, Zachary T. McEachin, Daniela C. Zarnescu, Paul R. August, Robert Bowser, Alexandre Betourne, Nadine Bakkar, Robert Kraft, Nicholas M. Boulis, Nathan Zahler, Justin K. Ichida, Samuel V. Alworth, Benjamin E. Rabichow, Wen-Hsuan Chang, Rita Sattler
Publikováno v:
Neurobiology of Disease, Vol 149, Iss, Pp 105228-(2021)
Disruption in copper homeostasis causes a number of cognitive and motor deficits. Wilson's disease and Menkes disease are neurodevelopmental disorders resulting from mutations in the copper transporters ATP7A and ATP7B, with ATP7A mutations also caus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1b093cb0d40dc3783f16c5e990d7e3b
http://www.sciencedirect.com/science/article/pii/S0969996120305039
http://www.sciencedirect.com/science/article/pii/S0969996120305039
Autor:
George A. Carlson, Evan Lester, Jacob I. Ayers, Felicia K. Ooi, Stanley B. Prusiner, Robert Bowser, Nadine Bakkar, Amanda L. Woerman, Joshua Wheeler, Roy Parker
Tau aggregates contribute to neurodegenerative diseases including frontotemporal dementia and Alzheimer’s disease (AD). Although RNA promotes tau aggregation in vitro, whether tau aggregates in cells contain RNA is unknown. We demonstrate in cell c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7ee8482b4bcb3d3c192cddd999c7efd
https://doi.org/10.1101/2021.01.27.428450
https://doi.org/10.1101/2021.01.27.428450
Autor:
Nadine Bakkar, Kyle Sponaugle, Ileana Lorenzini, Elenee Argentinis, Alix M. B. Lacoste, Philip Ferrante, Rita Sattler, Robert Bowser, Scott Spangler, Tina Kovalik
Publikováno v:
Acta Neuropathologica
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with no effective treatments. Numerous RNA-binding proteins (RBPs) have been shown to be altered in ALS, with mutations in 11 RBPs causing familial forms of the disease, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2232f10a1355c82fa12ede82b4c79371
https://doi.org/10.1007/s00401-017-1785-8
https://doi.org/10.1007/s00401-017-1785-8
Autor:
Nadine Bakkar, Jacob I. Ayers, Evan Lester, George A. Carlson, Stanley B. Prusiner, Felicia K. Ooi, Roy Parker, Robert Bowser, Amanda L. Woerman, Joshua Wheeler
Publikováno v:
Neuron
Summary Tau aggregates contribute to neurodegenerative diseases, including frontotemporal dementia and Alzheimer’s disease (AD). Although RNA promotes tau aggregation in vitro, whether tau aggregates in cells contain RNA is unknown. We demonstrate,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a228d7dd536c180f83ad5c907139f5ca
https://doi.org/10.1016/j.neuron.2021.03.026
https://doi.org/10.1016/j.neuron.2021.03.026
Autor:
Huating Wang, Jin Mo Gu, Jennifer M. Peterson, Sandya Liyanarachchi, Christopher E. Gaw, Vikram Shettigar, Mark T. Ziolo, Benjamin D. Canan, Jennifer M. Petrosino, Steve R. Roof, Sudarshana M. Sharma, Denis C. Guttridge, Nadine Bakkar, David J. Wang, Leina Lu, Paul M.L. Janssen, Jonathan P. Davis, Sean C. Little, Priya Londhe, Jonathan Shintaku, Nivedita M. Ratnam
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications
Nature Communications
Duchenne muscular dystrophy (DMD) is a neuromuscular disorder causing progressive muscle degeneration. Although cardiomyopathy is a leading mortality cause in DMD patients, the mechanisms underlying heart failure are not well understood. Previously,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f63bf87ccb4cd7d383c6c439c75e5c0f
https://doi.org/10.1038/s41467-018-05910-1
https://doi.org/10.1038/s41467-018-05910-1
Publikováno v:
Brain Research. 1607:94-107
The past decade has seen a dramatic increase in the discovery of candidate biomarkers for ALS. These biomarkers typically can either differentiate ALS from control subjects or predict disease course (slow versus fast progression). At the same time, l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72de5d45350de834de7e212cbf762e70
https://doi.org/10.1016/j.brainres.2014.10.031
https://doi.org/10.1016/j.brainres.2014.10.031
Autor:
Patrick Pirrotte, Robert Bowser, Nadine Bakkar, Krystine Garcia-Mansfield, Ashley Boehringer, Gurkaran Singh
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Mutations in Matrin 3 have recently been linked to ALS, though the mechanism that induces disease in these patients is unknown. To define the protein interactome of wild-type and ALS-linked MATR3 mutations, we performed immunoprecipitation followed b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::461d8b386bde8de60252f3d1d22a132d
http://europepmc.org/articles/PMC5674072
http://europepmc.org/articles/PMC5674072