Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Nadine Avenel"'
Autor:
Frédéric Féru, Yves Pascal, Marie-Pierre Pruniaux, Malika Ouagued, Charles R Andrianjara, Adrian Payne, Bernadette Bertin, Nadine Avenel, Sophie Lardon, Eric Auclair, Alain Calvet, Corinne M. Szilagyi, Indres Moodley
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:35-38
A novel series of benzodiazepine derivatives have been discovered as inhibitors of PDE4 enzymes. We have found that our compounds are selective versus other PDE enzymes, and that the activity can be modulated by specific structural modifications. One
Autor:
Eric Auclair, Veronique Fasquelle, Annette M. Doherty, Kam Chan, Stéphane Milano, Emmanuelle Lallier, Bernadette Bertin, Malika Ouagued, Marie-Noelle Rocher, Catherine Burnouf, Christèle Bigot, Brigitte Martin, Roger Wrigglesworth, Marie-Pierre Pruniaux, Richard B. Gilbertsen, Frederic Feru, Jocelyne Puaud, Nadine Avenel, Jacquie Maignel, Yves Pascal, Adel Kebsi, Calvet Alain Pierre, Henry Jacobelli, Christophe Terrasse, Corinne Durand
Publikováno v:
Journal of medicinal chemistry. 43(25)
The synthesis, structure-activity relationships, and biological properties of a novel series of potent and selective phosphodiesterase type 4 (PDE4) inhibitors are described. These new aminodiazepinoindoles displayed in vitro PDE4 activity with submi