Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Nadine Apetz"'
1
Akademický článek
Cerebellar Metabolic Connectivity during Treadmill Walking before and after Unilateral Dopamine Depletion in Rats
Autor: Heike Endepols, Nadine Apetz, Lukas Vieth, Christoph Lesser, Léon Schulte-Holtey, Bernd Neumaier, Alexander Drzezga
Publikováno v: International Journal of Molecular Sciences, Vol 25, Iss 16, p 8617 (2024)
Compensatory changes in brain connectivity keep motor symptoms mild in prodromal Parkinson’s disease. Studying compensation in patients is hampered by the steady progression of the disease and a lack of individual baseline controls. Furthermore, co
Externí odkaz: https://doaj.org/article/a8a0d3e4d18f492392e6d24ca344c228
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2
Akademický článek
Imaging of cerebral tryptophan metabolism using 7-[18F]FTrp-PET in a unilateral Parkinsonian rat model
Autor: Heike Endepols, Boris D. Zlatopolskiy, Johannes Zischler, Nazanin Alavinejad, Nadine Apetz, Stefanie Vus, Alexander Drzezga, Bernd Neumaier
Publikováno v: NeuroImage, Vol 247, Iss , Pp 118842- (2022)
Degradation products of the essential amino acid tryptophan (Trp) are important signaling molecules in the mammalian brain. Trp is metabolized either through the kynurenine pathway or enters serotonin and melatonin syntheses. The aim of the present w
Externí odkaz: https://doaj.org/article/acd2ba9d9d0a41de89c91dae238e3ac9
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3
Akademický článek
Effects of subthalamic deep brain stimulation on striatal metabolic connectivity in a rat hemiparkinsonian model
Autor: Nadine Apetz, Elena Kordys, Mascha Simon, Britta Mang, Markus Aswendt, Dirk Wiedermann, Bernd Neumaier, Alexander Drzezga, Lars Timmermann, Heike Endepols
Publikováno v: Disease Models & Mechanisms, Vol 12, Iss 5 (2019)
Deep brain stimulation (DBS) in the subthalamic nucleus (STN) has been successfully used for the treatment of advanced Parkinson's disease, although the underlying mechanisms are complex and not well understood. There are conflicting results about th
Externí odkaz: https://doaj.org/article/43b8cec2198f43e0bb03950be77c808c
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4
Imaging of cerebral tryptophan metabolism using 7-[
Autor: Heike, Endepols, Boris D, Zlatopolskiy, Johannes, Zischler, Nazanin, Alavinejad, Nadine, Apetz, Stefanie, Vus, Alexander, Drzezga, Bernd, Neumaier
Publikováno v: NeuroImage. 247
Degradation products of the essential amino acid tryptophan (Trp) are important signaling molecules in the mammalian brain. Trp is metabolized either through the kynurenine pathway or enters serotonin and melatonin syntheses. The aim of the present w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e0b1d1fd0eae5982b7a2a5b4e1a38c19
https://pubmed.ncbi.nlm.nih.gov/34942366
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5
Towards chronic deep brain stimulation in freely moving hemiparkinsonian rats: Applicability and functionality of a fully implantable stimulation system
Autor: Lars Timmermann, Gordon O. Munns, Alexander Drzezga, Kunal J. Paralikar, Erik R. Scott, Rajesh V. Iyer, Dirk Wiedermann, Bernd Neumaier, Heike Endepols, Nadine Apetz
Publikováno v: Journal of neural engineering 18(3), 036018-(2021). doi:10.1088/1741-2552/abe806
Journal of neural engineering 18(3), 036018 (2021). doi:10.1088/1741-2552/abe806
Abstract Objective. This study aimed at investigating a novel fully implantable deep brain stimulation (DBS) system and its ability to modulate brain metabolism and behavior through subthalamic nucleus (STN) stimulation in a hemiparkinsonian rat mode
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::800181cbac16113d994ae7223d7e0a7d
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6
Effects of subthalamic deep brain stimulation on striatal metabolic connectivity in a rat hemiparkinsonian model
Autor: Mascha Simon, Heike Endepols, Markus Aswendt, Britta Mang, Nadine Apetz, Alexander Drzezga, Elena Kordys, Dirk Wiedermann, Lars Timmermann, Bernd Neumaier
Publikováno v: Disease Models & Mechanisms
Disease models & mechanisms 12(5), dmm039065-(2019). doi:10.1242/dmm.039065
Disease Models & Mechanisms, Vol 12, Iss 5 (2019)
Deep brain stimulation (DBS) in the subthalamic nucleus (STN) has been successfully used for the treatment of advanced Parkinson's disease, although the underlying mechanisms are complex and not well understood. There are conflicting results about th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f92aa61f5795d2e7b32918d73dd09af4
http://europepmc.org/articles/PMC6550046
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8
Motor impairment and compensation in a hemiparkinsonian rat model: correlation between dopamine depletion severity, cerebral metabolism and gait patterns
Autor: Heike Endepols, Katharina Schneider, Michael Sué, Lars Timmermann, Alexander Drzezga, Cathrin Rohleder, Eilidh Duncan, Nadine Apetz, Elena Kordys, Beatriz Büschbell, Bernd Neumaier
Publikováno v: EJNMMI Research
EJNMMI Research 7(1), 68 (2017). doi:10.1186/s13550-017-0317-9
Background In Parkinson’s disease (PD), cerebral dopamine depletion is associated with PD subtype-specific metabolic patterns of hypo- and hypermetabolism. It has been hypothesised that hypometabolism reflects impairment, while hypermetabolism may
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::021e21a55dd062de710cb61cf6848acd
http://europepmc.org/articles/PMC5567589
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9
High levels of intravenous mephedrone (4-methylmethcathinone) self-administration in rats: Neural consequences and comparison with methamphetamine
Autor: Kong M. Li, John Ramsey, Adam R. Winstock, Jennifer L. Cornish, Nadine Apetz, Paul D. Callaghan, Iain S. McGregor, Craig P. Motbey, Michael T. Bowen, Kelly J. Clemens, Naomi Wyatt
Publikováno v: Journal of Psychopharmacology. 27:823-836
Mephedrone (MMC) is a relatively new recreational drug that has rapidly increased in popularity in recent years. This study explored the characteristics of intravenous MMC self-administration in the rat, with methamphetamine (METH) used as a comparat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78414ae23873a1c8578c0b56671136a8
https://doi.org/10.1177/0269881113490325
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10
Natural compounds and plant extracts as therapeutics against chronic inflammation in Alzheimer's disease--a translational perspective
Autor: Nadine Apetz, Erika Gyengesi, Gerald Münch, Suresh Govindaraghavan
Publikováno v: CNSneurological disorders drug targets. 13(7)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder, characterized by deposition of amyloid beta, neurofibrillary tangles, astrogliosis and microgliosis, leading to neuronal dysfunction and loss in the brain. Bio- and histochemical e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa25631777df586003f77bd5821df8d9
https://pubmed.ncbi.nlm.nih.gov/25230232
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