The genetic landscape of basal ganglia and implications for common brain disorders

Autor: Shahram Bahrami, Kaja Nordengen, Jaroslav Rokicki, Alexey A. Shadrin, Zillur Rahman, Olav B. Smeland, Piotr P. Jaholkowski, Nadine Parker, Pravesh Parekh, Kevin S. O’Connell, Torbjørn Elvsåshagen, Mathias Toft, Srdjan Djurovic, Anders M. Dale, Lars T. Westlye, Tobias Kaufmann, Ole A. Andreassen

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract The basal ganglia are subcortical brain structures involved in motor control, cognition, and emotion regulation. We conducted univariate and multivariate genome-wide association analyses (GWAS) to explore the genetic architecture of basal ga

Externí odkaz: https://doaj.org/article/2f1f263ef851499c8530865075d76cf0

Neurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm

Autor: Yuchao Jiang, Cheng Luo, Jijun Wang, Lena Palaniyappan, Xiao Chang, Shitong Xiang, Jie Zhang, Mingjun Duan, Huan Huang, Christian Gaser, Kiyotaka Nemoto, Kenichiro Miura, Ryota Hashimoto, Lars T. Westlye, Genevieve Richard, Sara Fernandez-Cabello, Nadine Parker, Ole A. Andreassen, Tilo Kircher, Igor Nenadić, Frederike Stein, Florian Thomas-Odenthal, Lea Teutenberg, Paula Usemann, Udo Dannlowski, Tim Hahn, Dominik Grotegerd, Susanne Meinert, Rebekka Lencer, Yingying Tang, Tianhong Zhang, Chunbo Li, Weihua Yue, Yuyanan Zhang, Xin Yu, Enpeng Zhou, Ching-Po Lin, Shih-Jen Tsai, Amanda L. Rodrigue, David Glahn, Godfrey Pearlson, John Blangero, Andriana Karuk, Edith Pomarol-Clotet, Raymond Salvador, Paola Fuentes-Claramonte, María Ángeles Garcia-León, Gianfranco Spalletta, Fabrizio Piras, Daniela Vecchio, Nerisa Banaj, Jingliang Cheng, Zhening Liu, Jie Yang, Ali Saffet Gonul, Ozgul Uslu, Birce Begum Burhanoglu, Aslihan Uyar Demir, Kelly Rootes-Murdy, Vince D. Calhoun, Kang Sim, Melissa Green, Yann Quidé, Young Chul Chung, Woo-Sung Kim, Scott R. Sponheim, Caroline Demro, Ian S. Ramsay, Felice Iasevoli, Andrea de Bartolomeis, Annarita Barone, Mariateresa Ciccarelli, Arturo Brunetti, Sirio Cocozza, Giuseppe Pontillo, Mario Tranfa, Min Tae M. Park, Matthias Kirschner, Foivos Georgiadis, Stefan Kaiser, Tamsyn E. Van Rheenen, Susan L. Rossell, Matthew Hughes, William Woods, Sean P. Carruthers, Philip Sumner, Elysha Ringin, Filip Spaniel, Antonin Skoch, David Tomecek, Philipp Homan, Stephanie Homan, Wolfgang Omlor, Giacomo Cecere, Dana D. Nguyen, Adrian Preda, Sophia I. Thomopoulos, Neda Jahanshad, Long-Biao Cui, Dezhong Yao, Paul M. Thompson, Jessica A. Turner, Theo G. M. van Erp, Wei Cheng, ENIGMA Schizophrenia Consortium, Jianfeng Feng, ZIB Consortium

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Abstract Machine learning can be used to define subtypes of psychiatric conditions based on shared biological foundations of mental disorders. Here we analyzed cross-sectional brain images from 4,222 individuals with schizophrenia and 7038 healthy su

Externí odkaz: https://doaj.org/article/76bdd81832814fb8a0f1d01e09c35de4

Shared genetic architecture between irritable bowel syndrome and psychiatric disorders reveals molecular pathways of the gut-brain axis

Autor: Markos Tesfaye, Piotr Jaholkowski, Guy F. L. Hindley, Alexey A. Shadrin, Zillur Rahman, Shahram Bahrami, Aihua Lin, Børge Holen, Nadine Parker, Weiqiu Cheng, Linn Rødevand, Oleksandr Frei, Srdjan Djurovic, Anders M. Dale, Olav B. Smeland, Kevin S. O’Connell, Ole A. Andreassen

Publikováno v: Genome Medicine, Vol 15, Iss 1, Pp 1-18 (2023)

Abstract Background Irritable bowel syndrome (IBS) often co-occurs with psychiatric and gastrointestinal disorders. A recent genome-wide association study (GWAS) identified several genetic risk variants for IBS. However, most of the heritability rema

Externí odkaz: https://doaj.org/article/d4cf61f95eec4b69bd69fd5c62edd34e

Shared genetic loci between depression and cardiometabolic traits.

Autor: Kristin Torgersen, Zillur Rahman, Shahram Bahrami, Guy Frederick Lanyon Hindley, Nadine Parker, Oleksandr Frei, Alexey Shadrin, Kevin S O'Connell, Martin Tesli, Olav B Smeland, John Munkhaugen, Srdjan Djurovic, Toril Dammen, Ole A Andreassen

Publikováno v: PLoS Genetics, Vol 18, Iss 5, p e1010161 (2022)

Epidemiological and clinical studies have found associations between depression and cardiovascular disease risk factors, and coronary artery disease patients with depression have worse prognosis. The genetic relationship between depression and these

Externí odkaz: https://doaj.org/article/5a79f08b00a84586ac3791821276945e

General Psychopathology, Cognition, and the Cerebral Cortex in 10-Year-Old Children: Insights From the Adolescent Brain Cognitive Development Study

Autor: Yash Patel, Nadine Parker, Giovanni A. Salum, Zdenka Pausova, Tomáš Paus

Publikováno v: Frontiers in Human Neuroscience, Vol 15 (2022)

General psychopathology and cognition are likely to have a bidirectional influence on each other. Yet, the relationship between brain structure, psychopathology, and cognition remains unclear. This brief report investigates the association between st

Externí odkaz: https://doaj.org/article/c6ed4292b04749d39312c4426e4d8cfb