Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Nadine, Mayotte"'
Autor:
Marie-Eve Bordeleau, Éric Audemard, Arnaud Métois, Louis Theret, Véronique Lisi, Azer Farah, Jean-François Spinella, Jalila Chagraoui, Ossama Moujaber, Léo Aubert, Banafsheh Khakipoor, Laure Mallinger, Isabel Boivin, Nadine Mayotte, Azadeh Hajmirza, Éric Bonneil, François Béliveau, Sybille Pfammatter, Albert Feghaly, Geneviève Boucher, Patrick Gendron, Pierre Thibault, Frédéric Barabé, Sébastien Lemieux, Guillaume Richard-Carpentier, Josée Hébert, Vincent-Philippe Lavallée, Philippe P. Roux, Guy Sauvageau
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114260- (2024)
Summary: Immunotherapy remains underexploited in acute myeloid leukemia (AML) compared to other hematological malignancies. Currently, gemtuzumab ozogamicin is the only therapeutic antibody approved for this disease. Here, to identify potential targe
Externí odkaz:
https://doaj.org/article/8cf475f1511748f0b536ab3c7b29e97a
Autor:
Jalila Chagraoui, Bernhard Lehnertz, Simon Girard, Jean Francois Spinella, Iman Fares, Elisa Tomellini, Nadine Mayotte, Sophie Corneau, Tara MacRae, Laura Simon, Guy Sauvageau
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0224900 (2019)
Elucidation of the molecular cues required to balance adult stem cell self-renewal and differentiation is critical for advancing cellular therapies. Herein, we report that the hematopoietic stem cell (HSC) self-renewal agonist UM171 triggers a balanc
Externí odkaz:
https://doaj.org/article/25a9012ffe7940d3b0c613d52f396eaf
Autor:
Réjean Ruel, Deanne Gracias, Bernhard Lehnertz, Jasmin Coulombe-Huntington, Geneviève Boucher, Richard Bisaillon, Guy Sauvageau, Sébastien Lemieux, Marie-Eve Bordeleau, Tara MacRae, Thierry Bertomeu, Nadine Mayotte, Josée Hébert, Céline Moison, Anne Marinier, Patrick Gendron, Mike Tyers, Isabel Boivin, Jana Krosl, Irène Baccelli, Frédéric Barabé, Rodrigo Mendoza-Sanchez, Vincent-Philippe Lavallée, Caroline Pabst, Nandita Noronha
Publikováno v:
Blood Advances
Key Points Inhibition of RAB protein function mediates the anti–acute myeloid leukemia activity of statins.Statin sensitivity is associated with enhanced vesicle-mediated traffic.
Visual Abstract
Cholesterol homeostasis has been proposed
Visual Abstract
Cholesterol homeostasis has been proposed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c795ab9cf3038006282d431d6e784f4
https://doi.org/10.1182/bloodadvances.2021006047
https://doi.org/10.1182/bloodadvances.2021006047
Autor:
Tara MacRae, Deanne Gracias, Nadine Mayotte, Sophie Corneau, Elisa Tomellini, Guy Sauvageau, Jalila Chagraoui, Isabel Boivin, Bernhard Lehnertz, Aurelie Durand
Publikováno v:
Blood. 138:2642-2654
Hematopoietic stem cells (HSCs) sustain blood cell homeostasis throughout life and can regenerate all blood lineages after transplantation. Despite this clear functional definition, highly enriched isolation of human HSCs can currently only be achiev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::511034c4dc235010db059dabb0731c47
https://doi.org/10.1182/blood.2021010745
https://doi.org/10.1182/blood.2021010745
Autor:
David Grote, Céline Moison, Stéphanie Duhamel, Jalila Chagraoui, Simon Girard, Jay Yang, Nadine Mayotte, Yan Coulombe, Jean-Yves Masson, Grant W. Brown, Sylvain Meloche, Guy Sauvageau
Publikováno v:
Cell Reports, Vol 11, Iss 2, Pp 210-219 (2015)
It has been previously shown that the polycomb protein BMI1 and E4F1 interact physically and genetically in the hematopoietic system. Here, we report that E4f1 is essential for hematopoietic cell function and survival. E4f1 deletion induces acute bon
Externí odkaz:
https://doaj.org/article/eea3de97076c4935830fbd6b151f051f
Identification of Novel Cell Surface Therapeutic Targets for KMT2A-Rearranged Acute Myeloid Leukemia
Autor:
Louis Theret, Marie-Eve Bordeleau, Azadeh Hajmirza, Arnaud Metois, Ossama Moujaber, Eric Audemard, Jean-Francois Spinella, Jalila Chagraoui, Léo Aubert, Azer Farah, Véronique Lisi, Eric Bonneil, Isabel Boivin, Nadine Mayotte, Tara MacRae, Pierre Thibault, Sébastien Lemieux, Vincent-Philippe Lavallée, Josee Hebert, Guy Sauvageau, Philippe P Roux
Publikováno v:
Blood. 140:6316-6317
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::123f0e173d7f5d4ab001711e2068e7c6
https://doi.org/10.1182/blood-2022-166769
https://doi.org/10.1182/blood-2022-166769
Autor:
Arnaud Metois, Marie-Eve Bordeleau, Louis Theret, Azadeh Hajmirza, Ossama Moujaber, Jean-François Spinella, Jalila Chagraoui, Nadine Mayotte, Isabel Boivin, Eric Audemard, Azer Farah, Véronique Lisi, Eric Bonneil, Pierre Thibault, Guillaume Richard-Carpentier, Vincent-Philippe Lavallée, Josee Hebert, Philippe P Roux, Guy Sauvageau
Publikováno v:
Blood. 140:11791-11792
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c53829d176da7839cbf73e8a2fead1c
https://doi.org/10.1182/blood-2022-166857
https://doi.org/10.1182/blood-2022-166857
Autor:
Azadeh Hajmirza, Laura Simon, Jalila Chagraoui, Nadine Mayotte, Jean-François Spinella, Tara Macrae, Bernhard Lehnertz, Thierry Bertomeu, Jasmin Coulombe-Huntington, Geneviève Boucher, Sébastien Lemieux, Mike Tyers, Josee Hebert, Guy Sauvageau
Publikováno v:
Blood. 140:8825-8826
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::015196cd24ae87d2bda8cf8c2dbbdf05
https://doi.org/10.1182/blood-2022-163685
https://doi.org/10.1182/blood-2022-163685
Autor:
Unain Ansari, Elisa Tomellini, Jalila Chagraoui, Bernhard Lehnertz, Nadine Mayotte, Marie-Eve Bordeleau, Philippe P. Roux, Guy Sauvageau
Publikováno v:
Blood advances. 6(12)
Key Points CEACAM1 is a novel cell surface marker of ex vivo expanded LT-HSCs. Sorting umbilical cord blood cells based on CEACAM1 and known HSC marker expression allows purification of LT-HSCs with improved purity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed00949075af7e2f5b3262723fc9fdde
https://pubmed.ncbi.nlm.nih.gov/35286394
https://pubmed.ncbi.nlm.nih.gov/35286394
Autor:
Céline Moison, Jean-François Spinella, Jalila Chagraoui, Vincent-Philippe Lavallée, Bernhard Lehnertz, Clarisse Thiollier, Isabel Boivin, Nadine Mayotte, Tara MacRae, Anne Marinier, Josée Hébert, Guy Sauvageau
Publikováno v:
Blood advances. 6(16)
High-mobility group AT-hook 2 (HMGA2) is a nonhistone chromatin-binding protein that is normally expressed in stem cells of various tissues and aberrantly detected in several tumor types. We recently observed that one-fourth of human acute myeloid le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::154015402d5ae71ea4449e5d8a99b392
https://pubmed.ncbi.nlm.nih.gov/35797243
https://pubmed.ncbi.nlm.nih.gov/35797243