Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Nadine, Huber"'
Autor:
Alberto Benussi, Valentina Cantoni, Mario Grassi, Ilenia Libri, Maria Sofia Cotelli, Barbara Tarantino, Abhishek Datta, Chris Thomas, Nadine Huber, Sari Kärkkäinen, Sanna-Kaisa Herukka, Annakaisa Haapasalo, Massimiliano Filosto, Alessandro Padovani, Barbara Borroni
Publikováno v:
Brain Stimulation, Vol 16, Iss 6, Pp 1666-1676 (2023)
Background: Amyotrophic lateral sclerosis (ALS) is a progressive disease for which no curative treatment is currently available. Objective: This study aimed to investigate whether cortico-spinal transcranial direct current stimulation (tDCS) could mi
Externí odkaz:
https://doaj.org/article/852b7bd38dfd4d10bdf3cf60ff7fcc1f
Autor:
Kasper Katisko, Nadine Huber, Tarja Kokkola, Päivi Hartikainen, Johanna Krüger, Anna-Leena Heikkinen, Veera Paananen, Ville Leinonen, Ville E. Korhonen, Seppo Helisalmi, Sanna-Kaisa Herukka, Valentina Cantoni, Yasmine Gadola, Silvana Archetti, Anne M. Remes, Annakaisa Haapasalo, Barbara Borroni, Eino Solje
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-10 (2022)
Abstract Background Frontotemporal dementia (FTD) covers a spectrum of neurodegenerative disorders with various clinical and neuropathological subtypes. The two major pathological proteins accumulating in the brains of FTD patients, depending on thei
Externí odkaz:
https://doaj.org/article/3f83909ddbda4779af3f6dea81f281ff
Autor:
Susanna Kemppainen, Nadine Huber, Roosa-Maria Willman, Ana Zamora, Petra Mäkinen, Henna Martiskainen, Mari Takalo, Annakaisa Haapasalo, Tomás Sobrino, Manuel Antonio González Gómez, Yolanda Piñeiro, José Rivas, Uwe Himmelreich, Mikko Hiltunen
Publikováno v:
Cells, Vol 12, Iss 10, p 1422 (2023)
Organotypic slice culture models surpass conventional in vitro methods in many aspects. They retain all tissue-resident cell types and tissue hierarchy. For studying multifactorial neurodegenerative diseases such as tauopathies, it is crucial to main
Externí odkaz:
https://doaj.org/article/b2d2b78497a14c988a671308b90b6410
Autor:
Markus T. Sainio, Tiina Rasila, Svetlana M. Molchanova, Julius Järvilehto, Rubén Torregrosa-Muñumer, Sandra Harjuhaahto, Jana Pennonen, Nadine Huber, Sanna-Kaisa Herukka, Annakaisa Haapasalo, Henrik Zetterberg, Tomi Taira, Johanna Palmio, Emil Ylikallio, Henna Tyynismaa
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2022)
Neurofilament light (NFL) is one of the proteins forming multimeric neuron-specific intermediate filaments, neurofilaments, which fill the axonal cytoplasm, establish caliber growth, and provide structural support. Dominant missense mutations and rec
Externí odkaz:
https://doaj.org/article/f4541e595e534acebc0b20319f10d18f
Autor:
Nadine Huber, Dorit Hoffmann, Raisa Giniatullina, Hannah Rostalski, Stina Leskelä, Mari Takalo, Teemu Natunen, Eino Solje, Anne M. Remes, Rashid Giniatullin, Mikko Hiltunen, Annakaisa Haapasalo
Publikováno v:
Neurobiology of Disease, Vol 162, Iss , Pp 105584- (2022)
Frontotemporal lobar degeneration (FTLD) comprises a heterogenous group of progressive neurodegenerative syndromes. To date, no validated biomarkers or effective disease-modifying therapies exist for the different clinical or genetic subtypes of FTLD
Externí odkaz:
https://doaj.org/article/0d8dcea9ac014ce6b915a51bc64162b9
Autor:
Sami Heikkinen, Nadine Huber, Kasper Katisko, Tarja Kokkola, Päivi Hartikainen, Johanna Krüger, Ville Leinonen, Ville E. Korhonen, Sanna-Kaisa Herukka, Anne M. Remes, Barbara Borroni, Antonella Alberici, Ilenia Libri, Eino Solje, Annakaisa Haapasalo
Publikováno v:
Journal of Alzheimer's Disease. 93:395-401
Frontotemporal dementia (FTD) can manifest as diverse clinical phenotypes and is frequently caused by mutations in different genes, complicating differential diagnosis. This underlines the urgent need for valid biomarkers. Altered lysosomal and immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ff0fd1610a1fd1dc0a0bb6d9e2985b8
https://doi.org/10.3233/jad-221060
https://doi.org/10.3233/jad-221060
Autor:
Hannah Rostalski, Tomi Hietanen, Stina Leskelä, Andrea Behánová, Ali Abdollahzadeh, Rebekka Wittrahm, Petra Mäkinen, Nadine Huber, Dorit Hoffmann, Eino Solje, Anne M. Remes, Teemu Natunen, Mari Takalo, Jussi Tohka, Mikko Hiltunen, Annakaisa Haapasalo
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Hexanucleotide repeat expansion (HRE) in the chromosome 9 open-reading frame 72 (C9orf72) gene is the most common genetic cause underpinning frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). It leads to the accumulatio
Externí odkaz:
https://doaj.org/article/7ee95a02d4244ed2974cb00b06245408
Autor:
Henna Martiskainen, Kaisa M. A. Paldanius, Teemu Natunen, Mari Takalo, Mikael Marttinen, Stina Leskelä, Nadine Huber, Petra Mäkinen, Enni Bertling, Hiramani Dhungana, Mikko Huuskonen, Paavo Honkakoski, Pirta Hotulainen, Kirsi Rilla, Jari Koistinaho, Hilkka Soininen, Tarja Malm, Annakaisa Haapasalo, Mikko Hiltunen
Publikováno v:
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-16 (2017)
Abstract Background DHCR24, involved in the de novo synthesis of cholesterol and protection of neuronal cells against different stress conditions, has been shown to be selectively downregulated in neurons of the affected brain areas in Alzheimer’s
Externí odkaz:
https://doaj.org/article/6ffdfce30aa34abe808f0d76198110f4
Autor:
Hannah Rostalski, Stina Leskelä, Nadine Huber, Kasper Katisko, Antti Cajanus, Eino Solje, Mikael Marttinen, Teemu Natunen, Anne M. Remes, Mikko Hiltunen, Annakaisa Haapasalo
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are neurodegenerative diseases with a complex, but often overlapping, genetic and pathobiological background and thus they are considered to form a disease spectrum. Alt
Externí odkaz:
https://doaj.org/article/e1d3a20842544134bab22774b056de7e
Autor:
Stina Leskelä, Nadine Huber, Hannah Rostalski, Teemu Natunen, Anne M. Remes, Mari Takalo, Mikko Hiltunen, Annakaisa Haapasalo
Publikováno v:
Cells, Vol 8, Iss 10, p 1233 (2019)
Dysfunctional autophagy or ubiquitin-proteasome system (UPS) are suggested to underlie abnormal protein aggregation in neurodegenerative diseases. Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS)-associated C9orf72 is implicated
Externí odkaz:
https://doaj.org/article/c9b4569e0b284adbac56383fede625f7