Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Nadine, Hövelmeyer"'
Natural antibodies are required for clearance of necrotic cells and recovery from acute liver injury
Autor:
Matheus Silvério Mattos, Sofie Vandendriessche, Sara Schuermans, Lars Feyaerts, Nadine Hövelmeyer, Ari Waisman, Pedro Elias Marques
Publikováno v:
JHEP Reports, Vol 6, Iss 4, Pp 101013- (2024)
Background & Aims: Hepatocellular necrosis is common in both acute and chronic liver injury and may evolve to fibrosis and liver failure. Injury leads to accumulation of necrotic cell debris in the liver, which drives persistent inflammation and poor
Externí odkaz:
https://doaj.org/article/3681b72ea6c4469fba06d59638e27087
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Colorectal cancer (CRC) is a complex and heterogeneous disease characterized by dysregulated interactions between tumor cells and the immune system. The tumor microenvironment plays a pivotal role in cancer initiation as well as progression, with mye
Externí odkaz:
https://doaj.org/article/ed205b08bf2948a390fdb58d49b731e2
Autor:
Eva-Maria Cox, Mohamed El-Behi, Stefanie Ries, Johannes F. Vogt, Vivien Kohlhaas, Thomas Michna, Benoît Manfroi, Mona Al-Maarri, Florian Wanke, Boaz Tirosh, Corinne Pondarre, Harry Lezeau, Nir Yogev, Romy Mittenzwei, Marc Descatoire, Sandra Weller, Jean-Claude Weill, Claude-Agnès Reynaud, Pierre Boudinot, Luc Jouneau, Stefan Tenzer, Ute Distler, Anne Rensing-Ehl, Christoph König, Julian Staniek, Marta Rizzi, Aude Magérus, Frederic Rieux-Laucat, F. Thomas Wunderlich, Nadine Hövelmeyer, Simon Fillatreau
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112378- (2023)
Summary: The signals controlling marginal zone (MZ) and follicular (FO) B cell development remain incompletely understood. Here, we show that AKT orchestrates MZ B cell formation in mice and humans. Genetic models that increase AKT signaling in B cel
Externí odkaz:
https://doaj.org/article/92cc14fd0e5540159395986a3869f5d7
Autor:
Nadine Gehrke, Marcus A. Wörns, Amrit Mann, Nadine Hövelmeyer, Ari Waisman, Beate K. Straub, Peter R. Galle, Jörn M. Schattenberg
Publikováno v:
Cell Death and Disease, Vol 13, Iss 5, Pp 1-12 (2022)
Abstract Acute liver failure (ALF) is a rare entity but exhibits a high mortality. The mechanisms underlying ALF are not completely understood. The present study explored the role of the hepatic B cell leukemia-3 (Bcl-3), a transcriptional regulator
Externí odkaz:
https://doaj.org/article/a7c9f6bc2f78494daefe0132b228da87
Autor:
Anna Juliane Vesting, Alexander Jais, Paul Klemm, Lukas Steuernagel, Peter Wienand, Morten Fog-Tonnesen, Henning Hvid, Anna–Lena Schumacher, Christian Kukat, Hendrik Nolte, Theodoros Georgomanolis, Janine Altmüller, Manolis Pasparakis, Andreas Schmidt, Marcus Krüger, Marc Schmidt Supprian, Ari Waisman, Beate Katharina Straub, Nathanael Raschzok, Michel Bernier, Andreas L. Birkenfeld, Nadine Hövelmeyer, Jens C. Brüning, F. Thomas Wunderlich
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101626- (2022)
Objective: Nonalcoholic fatty liver disease (NAFLD) ranges from steatosis to nonalcoholic steatohepatitis (NASH), which often progresses to hepatocellular carcinoma (HCC) through a largely undefined mechanism. NASH and HCC depend on inflammatory sign
Externí odkaz:
https://doaj.org/article/2bae8d5e2cd240e7ae3c80f88b871897
Autor:
Claudia M. Wunderlich, P. Justus Ackermann, Anna Lena Ostermann, Petra Adams-Quack, Merly C. Vogt, My-Ly Tran, Alexei Nikolajev, Ari Waisman, Christoph Garbers, Sebastian Theurich, Jan Mauer, Nadine Hövelmeyer, F. Thomas Wunderlich
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Inflammation can be induced by obesity, and has been linked with onset of colorectal cancer (CAC). Here the authors show in mouse models that obesity-induced interleukin-6 alters macrophage function to enhance CCL-20/CCR-6-mediated recruitment of B c
Externí odkaz:
https://doaj.org/article/8aa769939cda447285b994dfedfa8895
Autor:
Ning Xia, Solveig Hasselwander, Gisela Reifenberg, Alice Habermeier, Ellen I. Closs, Maximilian Mimmler, Rebecca Jung, Susanne Karbach, Jérémy Lagrange, Philip Wenzel, Andreas Daiber, Thomas Münzel, Nadine Hövelmeyer, Ari Waisman, Huige Li
Publikováno v:
Biomedicines, Vol 9, Iss 11, p 1686 (2021)
B lymphocytes have been implicated in the development of insulin resistance, atherosclerosis and certain types of hypertension. In contrast to these studies, which were performed under pathological conditions, the present study provides evidence for
Externí odkaz:
https://doaj.org/article/ae5f35f2a9c24aa0be52938250a875bd
Autor:
Sonja Reißig, Yilang Tang, Alexei Nikolaev, Katharina Gerlach, Christine Wolf, Kathrin Davari, Christian Gallus, Joumana Masri, Ilgiz A. Mufazalov, Markus F. Neurath, F. Thomas Wunderlich, Jörn M. Schattenberg, Peter R. Galle, Benno Weigmann, Ari Waisman, Elke Glasmacher, Nadine Hövelmeyer
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Bcl-3 modulates effector T cell responses, but the importance of Bcl-3 in T regulatory cells and autoimmunity is not clear. Here the authors show that Bcl-3 impedes NF-κB DNA binding to alter T regulatory cell development and function, causing spont
Externí odkaz:
https://doaj.org/article/87d328bf46c940f9b17786b9c4f283ce
Autor:
Burkhard Becher, Lubor Borsig, Ari Waisman, Christian Gorzelanny, Gabor Gyülvészi, Nadine Hövelmeyer, Andrew L. Croxford, Joanna Mikita-Geoffroy, Sara Burkhard, Paulina Kulig
The role of the IL23/IL17A axis in tumor–immune interactions is a matter of controversy. Although some suggest that IL17A-producing T cells (TH17) can suppress tumor growth, others report that IL17A and IL23 accelerate tumor growth. Here, we system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e34b7410518e3eccf2690eb7f342ba79
https://doi.org/10.1158/2326-6066.c.6548816.v1
https://doi.org/10.1158/2326-6066.c.6548816.v1
Autor:
Burkhard Becher, Lubor Borsig, Ari Waisman, Christian Gorzelanny, Gabor Gyülvészi, Nadine Hövelmeyer, Andrew L. Croxford, Joanna Mikita-Geoffroy, Sara Burkhard, Paulina Kulig
Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb85128805af69b3bad1fb5c7b10161
https://doi.org/10.1158/2326-6066.22538582.v1
https://doi.org/10.1158/2326-6066.22538582.v1