Zobrazeno 1 - 10
of 271
pro vyhledávání: '"Nadim A. Ajami"'
Autor:
Samantha Franklin, Samuel L. Aitken, Yushi Shi, Pranoti V. Sahasrabhojane, Sarah Robinson, Christine B. Peterson, Naval Daver, Nadim A. Ajami, Dimitrios P. Kontoyiannis, Samuel A. Shelburne, Jessica Galloway-Peña
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Failure to maintain segregation of oral and gut microbial communities has been linked to several diseases. We sought to characterize oral-fecal microbiome community coalescence, ectopic extension of oral bacteria, clinical variables contributing to t
Externí odkaz:
https://doaj.org/article/fa6a0fdef875457a8afce22c6e36d929
Intratumoral microbiome of adenoid cystic carcinomas and comparison with other head and neck cancers
Autor:
Tatiana V. Karpinets, Yoshitsugu Mitani, Chia-Chi Chang, Xiaogang Wu, Xingzhi Song, Ivonne I. Flores, Lauren K. McDaniel, Yasmine M. Hoballah, Fabiana J. Veguilla, Renata Ferrarotto, Lauren E. Colbert, Nadim J. Ajami, Robert R. Jenq, Jianhua Zhang, Andrew P. Futreal, Adel K. El-Naggar
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Adenoid cystic carcinoma (ACC) is a rare, usually slow-growing yet aggressive head and neck malignancy. Despite its clinical significance, our understanding of the cellular evolution and microenvironment in ACC remains limited. We investigat
Externí odkaz:
https://doaj.org/article/e1c7c9a7f34347698b377e27634d3bc8
Autor:
Jake Lin, Elaheh Moradi, Karoliina Salenius, Suvi Lehtipuro, Tomi Häkkinen, Jutta E. Laiho, Sami Oikarinen, Sofia Randelin, Hemang M. Parikh, Jeffrey P. Krischer, Jorma Toppari, Åke Lernmark, Joseph F. Petrosino, Nadim J. Ajami, Jin-Xiong She, William A. Hagopian, Marian J. Rewers, Richard E. Lloyd, Kirsi J. Rautajoki, Heikki Hyöty, Matti Nykter, the TEDDY Study Group
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Although the genetic basis and pathogenesis of type 1 diabetes have been studied extensively, how host responses to environmental factors might contribute to autoantibody development remains largely unknown. Here, we use longitudinal blood t
Externí odkaz:
https://doaj.org/article/80ebd0159183481dafbd9063fd5905f9
Autor:
Jacob H. Elnaggar, Victoria O. Huynh, Daniel Lin, R. Tyler Hillman, Chike O. Abana, Molly B. El Alam, Katarina C. Tomasic, Tatiana V. Karpinets, Ramez Kouzy, Jae L. Phan, Jennifer Wargo, Emma B. Holliday, Prajnan Das, Melissa P. Mezzari, Nadim J. Ajami, Erica J. Lynn, Bruce D. Minsky, Van K. Morris, Andrea Milbourne, Craig A. Messick, Ann H. Klopp, P. Andrew Futreal, Cullen M. Taniguchi, Kathleen M. Schmeler, Lauren E. Colbert
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundSquamous cell carcinoma of the anus (SCCA) is a rare gastrointestinal cancer. Factors associated with progression of HPV infection to anal dysplasia and cancer are unclear and screening guidelines and approaches for anal dysplasia are less
Externí odkaz:
https://doaj.org/article/24e00470215b468e8484d70a543c2072
Autor:
Tina Cascone, Annikka Weissferdt, Myrna C. B. Godoy, William N. William, Cheuk H. Leung, Heather Y. Lin, Sreyashi Basu, Shalini S. Yadav, Apar Pataer, Kyle G. Mitchell, Md Abdul Wadud Khan, Yushu Shi, Cara Haymaker, Luisa M. Solis, Edwin R. Parra, Humam Kadara, Ignacio I. Wistuba, Padmanee Sharma, James P. Allison, Nadim J. Ajami, Jennifer A. Wargo, Robert R. Jenq, Don L. Gibbons, J. Jack Lee, Stephen G. Swisher, Ara A. Vaporciyan, John V. Heymach, Boris Sepesi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Granulomatous/sarcoid-like lesions have been reported in patients treated with immune checkpoint inhibitors (ICIs). Here the authors report the occurrence of “nodal immune flare”, an apparent radiological cancer progression in the nodes character
Externí odkaz:
https://doaj.org/article/02f55269e7f9462fb8c8389a4b130848
Autor:
Katherine Laiton-Donato, Camila Guzmán, Erik Perdomo-Balaguera, Ladys Sarmiento, Orlando Torres-Fernandez, Héctor Alejandro Ruiz, Alicia Rosales-Munar, Dioselina Peláez-Carvajal, Maria-Cristina Navas, Matthew C. Wong, Sandra Junglen, Nadim J. Ajami, Gabriel Parra-Henao, José A. Usme-Ciro
Publikováno v:
Viruses, Vol 15, Iss 4, p 953 (2023)
The family Tymoviridae comprises positive-sense RNA viruses, which mainly infect plants. Recently, a few Tymoviridae-like viruses have been found in mosquitoes, which feed on vertebrate sources. We describe a novel Tymoviridae-like virus, putatively
Externí odkaz:
https://doaj.org/article/186cad04cf1e4fe9a44fab4ff2e28376
Autor:
Grace T. Patterson, Elvia Y. Osorio, Alex Peniche, Sara M. Dann, Erika Cordova, Geoffrey A. Preidis, Ji Ho Suh, Ichiaki Ito, Omar A. Saldarriaga, Michael Loeffelholz, Nadim J. Ajami, Bruno L. Travi, Peter C. Melby
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Acute malnutrition, or wasting, is implicated in over half of all deaths in children under five and increases risk of infectious disease. Studies in humans and preclinical models have demonstrated that malnutrition is linked to an immature intestinal
Externí odkaz:
https://doaj.org/article/798f5b8d15854f23adeb949f3d0fee69
Autor:
Travis T. Sims, Molly B. El Alam, Tatiana V. Karpinets, Stephanie Dorta-Estremera, Venkatesh L. Hegde, Sita Nookala, Kyoko Yoshida-Court, Xiaogang Wu, Greyson W. G. Biegert, Andrea Y. Delgado Medrano, Travis Solley, Mustapha Ahmed-Kaddar, Bhavana V. Chapman, K. Jagannadha Sastry, Melissa P. Mezzari, Joseph F. Petrosino, Lilie L. Lin, Lois Ramondetta, Anuja Jhingran, Kathleen M. Schmeler, Nadim J. Ajami, Jennifer Wargo, Lauren E. Colbert, Ann H. Klopp
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Travis Sims and Molly El Alam et al. show that diversity of gut microbiota is associated with a favorable response to chemoradiation for cervical cancer and use flow cytometry to show that patients with high microbiome diversity had increased tumor i
Externí odkaz:
https://doaj.org/article/c76ee253ea0f4e5b85dab20f72cbe758
Autor:
Melinda A. Engevik, Lori D. Banks, Kristen A. Engevik, Alexandra L. Chang-Graham, Jacob L. Perry, Diane S. Hutchinson, Nadim J. Ajami, Joseph F. Petrosino, Joseph M. Hyser
Publikováno v:
Gut Microbes, Vol 11, Iss 5, Pp 1324-1347 (2020)
Multiple studies have identified changes within the gut microbiome in response to diarrheal-inducing bacterial pathogens. However, examination of the microbiome in response to viral pathogens remains understudied. Compounding this, many studies use f
Externí odkaz:
https://doaj.org/article/8c2256208e634e9b87d3022a100bfe3d
Autor:
Romualdo Barroso-Sousa, Tianyu Li, Ashish V. Damania, Molly K. DiLullo, Tanya Keenan, Gerburg M. Wulf, Laura M. Spring, Elizabeth A. Mittendorf, Jennifer A. Ligibel, Nadim J. Ajami, Jennifer Wargo, Nabihah Tayob, Sara Tolaney
Publikováno v:
Cancer Research. 83:PD11-05
Background: The gut microbiome modulates response and resistance to immune checkpoint inhibitors (ICI) across different cancer types. The objective of this study was to explore the association between fecal microbiome profiles and clinical outcomes i