Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Nadia T. Al-Qurashi"'
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Structure Determination and Quantum Chemical Analysis of 1,3-Dipolar Cycloaddition of Nitrile Imines and New Dipolarophiles and POM Analyses of the Products as Potential Breast Cancer Inhibitors
Autor: Thoraya A. Farghaly, Ikhlass M. Abbas, Walid Hassan, Nadia T. Al-Qurashi, M. S. Lotfy, T. Ben Hadda
Publikováno v: Russian Journal of Organic Chemistry. 56:1258-1271
The 1,3-dipolar cycloaddition of nitrile imines to 11-aryl-4-(arylmethylidene)-1,2,3,4,11,11a-hexahydrodibenzo[b,e][1,4]thiazepines possessing exocyclic C=C and endocyclic C=N bonds as dipolarophilic sites showed site selectivity, depending on the ty
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eaa3498ce9135ba61e6e087c96ab5490
https://doi.org/10.1134/s1070428020070210
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5
Discovery of novel indolyl-1,2,4-triazole hybrids as potent vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitors with potential anti-renal cancer activity
Autor: Thoraya A. Farghaly, Nadia T. Al-Qurashi, Sami A. Al-Hussain, Hanan Gaber Abdulwahab, Zeinab A. Muhammad, Magdi E. A. Zaki
Publikováno v: Bioorganic chemistry. 105
Targeting VEGFR-2 signaling pathway is well-established as an important approach for the treatment of solid tumors, particularly renal cancer. Herein, novel indolyl-1,2,4-triazole hybrids were designed and synthesized as VEGFR-2 kinase inhibitors wit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf517db890395134163b3635592b7857
https://pubmed.ncbi.nlm.nih.gov/33038552
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6
Novel 2-indolinone thiazole hybrids as sunitinib analogues: Design, synthesis, and potent VEGFR-2 inhibition with potential anti-renal cancer activity
Autor: Huda K. Mahmoud, Hanan Gaber Abdulwahab, Nadia T. Al-Qurashi, Mohamed R. Shaaban, Thoraya A. Farghaly
Publikováno v: European journal of medicinal chemistry. 208
Novel 2-indolinone thiazole hybrids were designed and synthesized as VEGFR-2 inhibitors based on sunitinib, an FDA-approved anticancer drug. The proposed structures of the prepared 2-indolinone thiazole hybrids were confirmed based on their spectral
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26127ee5316063c1c4ab25274c60d79f
https://pubmed.ncbi.nlm.nih.gov/32947227
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8
Indomethacin Analogs: Synthesis, Anti-inflammatory and Analgesic Activities of Indoline Derivatives
Autor: Huda K. Mahmoud, Thoraya A. Farghaly, Mohamed R. Shaaban, Mohamed M. Amin, Nadia T. Al-Qurashi
Publikováno v: Mini-Reviews in Medicinal Chemistry. 18:1409-1421
Background Microwave assisted reactions offer a considerable advantages over conventional method reactions because the former results in substantial rate enhancement in a wide range of organic reactions. Objective we interested herein to prepare new
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fff374d8e22cccd96f70932cd5bfba8
https://doi.org/10.2174/1389557518666180330101447
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10
Synthesis under microwaves irradiation, structure elucidation, docking study for inhibiting COVID-19 and DFT calculations of novel azoles incorporated indole moiety
Autor: Umar Farooq, Thoraya A. Farghaly, Ismail Althagafi, Nadia T. Al-Qurashi, Mona H. Ibrahim
Publikováno v: Journal of Molecular Structure. 1244:131263
In short reaction time with excellent yield, we designed and synthesized a series of indole linked azole ring at position-2 as thiazole and pyrazole moieties under microwaves irradiation. The structures and mechanistic pathways were discussed in this
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c8755f53a4d9c187c106a8fc16edf21
https://doi.org/10.1016/j.molstruc.2021.131263
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