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pro vyhledávání: '"Nadia Sukhova"'
Autor:
Joyce A. Goldstein, Nadia Sukhova, Linda W. Pickle, Raymond L. Woosley, James W. Harris, Jan Hewett, John D. Balian, David A. Flockhart
Publikováno v:
Clinical pharmacology and therapeutics. 57(6)
We compared omeprazole and mephenytoin as probes for the CYP2C19 metabolic polymorphism. Single oral doses of omeprazole (20 mg) or mephenytoin (100 mg) were administered at least 1 week apart to 167 healthy volunteers. Mephenytoin metabolism was mea