Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Nadia Soukhova"'
Publikováno v:
Clinica Chimica Acta. 358:113-118
Most clinical chemistry laboratories measure free thyroxine (FT4) by an analogue (direct) method. Nevertheless, the validity of analogue FT4 immunoassays has been questioned and patient's results using this approach frequently do not fit in with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a66efc4d90d006e07b0ebc0a46014341
https://doi.org/10.1016/j.cccn.2005.02.010
https://doi.org/10.1016/j.cccn.2005.02.010
Publikováno v:
Clinica Chimica Acta. 343:185-190
Background : The thyroid hormones thyroxine (T4) and 3,5,3′-triidothyronine (T3) are essential for regulating a number of biological processes, including growth, neurodevelopment, carbohydrate metabolism, oxygen consumption and protein synthesis. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd98692031ab5a78fee96c99280369f
https://doi.org/10.1016/j.cccn.2004.01.007
https://doi.org/10.1016/j.cccn.2004.01.007
Publikováno v:
Drug Metabolism and Disposition. 30:525-530
Cytochrome P450 2B6 is a genetically polymorphic enzyme that is important in the metabolism of a number of clinically used drugs. This enzyme is not as well studied as other cytochrome P450 (P450) isoforms because of the lack of specific antibodies,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d49e1333a243fe3da5c11463aeed84cc
https://doi.org/10.1124/dmd.30.5.525
https://doi.org/10.1124/dmd.30.5.525
Autor:
Jari J. Lilja, Nadia Soukhova, Zeruesenay Desta, Janne T. Backman, David A. Flockhart, Pertti J. Neuvonen, Kari T. Kivistö
Publikováno v:
British Journal of Clinical Pharmacology. 52:399-407
Aims To determine whether the pharmacokinetics of cisapride and its interaction with grapefruit juice are stereoselective. Methods The study was a randomized, two-phase cross over design with a washout period of 2 weeks. Ten healthy volunteers were p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d899a31642caef55f72ea11e8abf8b1d
https://doi.org/10.1046/j.0306-5251.2001.01473.x
https://doi.org/10.1046/j.0306-5251.2001.01473.x
Autor:
Nadia Soukhova, Alan Morocho, Subena K. Mahal, Jae Park, David A. Flockhart, Zeruesenay Desta
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 744:263-272
We have developed a simple, sensitive, specific and reproducible stereoselective high-performance liquid chromatography technique for analytical separation of cisapride enantiomers and measurement of cisapride enantiomers in human plasma. A chiral an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::895b8d8f62f7c82e820db977eadf4a74
https://doi.org/10.1016/s0378-4347(00)00247-4
https://doi.org/10.1016/s0378-4347(00)00247-4
Autor:
Thomas Kerbusch, Philip L. Pearle, David A. Flockhart, Milou-daniel Drici, Victoria J. Babb, Subena K. Mahal, Nadia Soukhova, Emily Richard
Publikováno v:
Journal of Clinical Psychopharmacology. 20:317-324
The authors report in detail the case of a 27-year-old man who experienced sudden cardiac death 2 days after coprescription of the neuroleptic pimozide and the macrolide antibiotic clarithromycin after the documentation of a prolonged QT interval. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0184be2487c6975dfad82f49a176789d
https://doi.org/10.1097/00004714-200006000-00005
https://doi.org/10.1097/00004714-200006000-00005
Publikováno v:
British Journal of Clinical Pharmacology. 49:343-351
Aims To examine the potency of ticlopidine (TCL) as an inhibitor of cytochrome P45()s (CYP450s) in vitro using human liver microsomes (HLMs) and recombinant human CYP450s. Methods Isoform-specific substrate probes of CYP1A2, 2C19, 2C9, 2D6, 2E1 and 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::621ff875688619d8ced963837d33d6d4
https://doi.org/10.1046/j.1365-2125.2000.00175.x
https://doi.org/10.1046/j.1365-2125.2000.00175.x
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 694:163-168
A method is described for the measurement of pimozide in human plasma using HPLC with fluorescence detection. The method is specific and sensitive in the range of concentrations seen in human plasma after conventional dosing (1–15 ng/ml) with a lim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4c4d92a9a28da615f821f0701372d40
https://doi.org/10.1016/s0378-4347(97)00152-7
https://doi.org/10.1016/s0378-4347(97)00152-7
Publikováno v:
Clinica chimica acta; international journal of clinical chemistry. 358(1-2)
Tandem mass spectrometry (MS/MS) is being increasingly used to identify and measure acylcarnitines in blood and urine of children suspected of having fatty oxidation disorders and other inborn errors of metabolism. Rapid MS/MS analysis requires simpl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f154d289092aadcdb8920e71bf181a7
https://pubmed.ncbi.nlm.nih.gov/16018880
https://pubmed.ncbi.nlm.nih.gov/16018880
Publikováno v:
Journal of clinical psychopharmacology. 22(2)
Pimozide is often coprescribed with serotonin reuptake inhibitor (SSRI) antidepressants to treat depression in patients with Tourette's syndrome. In human liver microsomes (HLMs), the inhibition of the primary route of pimozide metabolism, N-dealkyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::478dfc8efeb9dc023a1c9a2894338118
https://pubmed.ncbi.nlm.nih.gov/11910261
https://pubmed.ncbi.nlm.nih.gov/11910261