Výsledky vyhledávání

Structural basis and dynamics of Chikungunya alphavirus RNA capping by nsP1 capping pores

Autor: Rhian Jones, Michael Hons, Nadia Rabah, Noelia Zamarreño, Rocío Arranz, Juan Reguera

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2023, 120 (12), ⟨10.1073/pnas.2213934120⟩

Alphaviruses are emerging positive-stranded RNA viruses which replicate and transcribe their genomes in membranous organelles formed in the cell cytoplasm. The nonstructural protein 1 (nsP1) is responsible for viral RNA capping and gates the replicat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9abd0d33db918b7cb428798d9091820d
https://doi.org/10.1073/pnas.2213934120

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Structure, function and dynamics of alphavirus capping pores

Autor: Rhian Jones, Michael Hons, Nadia Rabah, Noelia Zamarreno Fernandez, Rocio Arranz Avila, Juan Reguera

Publikováno v: Biophysical Journal. 122:305a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4e2aac4e254daf173989b3a09c4de446
https://doi.org/10.1016/j.bpj.2022.11.1719

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Structure and Sequence Requirements for RNA Capping at the Venezuelan Equine Encephalitis Virus RNA 5′ End

Autor: Etienne Decroly, Nadia Rabah, Oney Ortega Granda, Coralie Valle, Bruno Canard, Ashleigh Shannon, Bruno Coutard

Publikováno v: Journal of Virology
Journal of Virology, 2021, 95 (15), ⟨10.1128/JVI.00777-21⟩
Journal of Virology, American Society for Microbiology, 2021, 95 (15), ⟨10.1128/JVI.00777-21⟩
J Virol

Venezuelan equine encephalitis virus (VEEV) is a reemerging arthropod-borne virus causing encephalitis in humans and domesticated animals. VEEV possesses a positive single-stranded RNA genome capped at its 5′ end. The capping process is performed b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d172695d8398d5ebc28566948e143856
https://doi.org/10.1128/jvi.00777-21

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Protein-primed RNA synthesis in SARS-CoVs and structural basis for inhibition by AT-527

SummaryHow viruses from the Coronaviridae family initiate viral RNA synthesis is unknown. Here we show that the SARS-CoV-1 and −2 Nidovirus RdRp-Associated Nucleotidyltransferase (NiRAN) domain on nsp12 uridylates the viral cofactor nsp8, forming a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1e1d77f43ab95d6f58607895a539c39
https://doi.org/10.1101/2021.03.23.436564

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Mutations on VEEV nsP1 relate RNA capping efficiency to ribavirin susceptibility

Autor: Bruno Coutard, Nadia Rabah, Oney Ortega Granda, Bruno Canard, Gilles Querat, Etienne Decroly

Publikováno v: Antiviral Research
Antiviral Research, 2020, 182, pp.104883. ⟨10.1016/j.antiviral.2020.104883⟩
Antiviral Research, Elsevier Masson, 2020, 182, pp.104883. ⟨10.1016/j.antiviral.2020.104883⟩

International audience; Alphaviruses are arthropod-borne viruses of public health concern. To date no efficient vaccine nor antivirals are available for safe human use. During viral replication the nonstructural protein 1 (nsP1) catalyzes capping of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aaf67467e0f3738b24b68e750fb86d2
https://hal.science/hal-03030827/document

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Les protéines non structurales des Alphavirus : rôle dans la réplication et l'interaction du virus avec la cellule hôte

Autor: Nadia, Rabah, Bruno, Coutard, Bruno, Canard

Publikováno v: Virologie (Montrouge, France). 17(1)

Alphaviruses (genus of the family Togaviridae) are emergent arthropod borne viruses. They can cause mild to severe diseases including fever, arthritis, and in certain cases encephalitis leading to neurological sequels. Alphaviruses are enveloped, sin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e80ceb8713dc44d7315d986dbabfc566
https://pubmed.ncbi.nlm.nih.gov/31910548

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The C-terminal region of the proprotein convertase 1/3 (PC1/3) exerts a bimodal regulation of the enzyme activity in vitro

Autor: Dany Gauthier, Jimmy D. Dikeakos, Claude Lazure, Timothy L. Reudelhuber, Nadia Rabah

Publikováno v: FEBS Journal. 274:3482-3491

The proprotein convertase PC1/3 preferentially cleaves its substrates in the dense core secretory granules of endocrine and neuroendocrine cells. Similar to most proteinases synthesized first as zymogens, PC1/3 is synthesized as a larger precursor th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d284d085758e7158ca8d7df838992284
https://doi.org/10.1111/j.1742-4658.2007.05883.x

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Arenavirus Glycan Shield Promotes Neutralizing Antibody Evasion and Protracted Infection

Autor: Melissa Remy, Paul-Henri Lambert, Claire-Anne Siegrist, Bruno Coutard, Sébastien Igonet, Giovanni Magistrelli, Dorothée Rigo, Pauline Malinge, Nicolas Fischer, Daniel D. Pinschewer, Thomas A. Bowden, Andreas Bergthaler, Lukas Flatz, Nadia Rabah, Jan ter Meulen, Mehmet Sahin, Paolo Meda, Rami Sommerstein

Publikováno v: PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2015, 11 (11), ⟨10.1371/journal.ppat.1005276⟩
PLoS Pathog
PLoS Pathogens, Vol 11, Iss 11, p e1005276 (2015)
PLoS Pathogens, 2015, 11 (11), ⟨10.1371/journal.ppat.1005276⟩
PLOS Pathogens, Vol. 11, No 11 (2015) P. e1005276

Arenaviruses such as Lassa virus (LASV) can cause severe hemorrhagic fever in humans. As a major impediment to vaccine development, delayed and weak neutralizing antibody (nAb) responses represent a unifying characteristic of both natural infection a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a35e41b794cacb959bec395e2a198c8c
https://hal.archives-ouvertes.fr/hal-01439028

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