Výsledky vyhledávání - "Nadia P Belichenko"

Akademický článek

A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression.

Autor: Danielle A Simmons, Juliet K Knowles, Nadia P Belichenko, Gargi Banerjee, Carly Finkle, Stephen M Massa, Frank M Longo

Publikováno v: PLoS ONE, Vol 9, Iss 8, p e102136 (2014)

Degeneration of basal forebrain cholinergic neurons contributes significantly to the cognitive deficits associated with Alzheimer's disease (AD) and has been attributed to aberrant signaling through the neurotrophin receptor p75 (p75NTR). Thus, modul

Externí odkaz: https://doaj.org/article/ce298275ec274c88bc28dc54ea0e96ff

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Akademický článek

Evidence for both neuronal cell autonomous and nonautonomous effects of methyl-CpG-binding protein 2 in the cerebral cortex of female mice with Mecp2 mutation

Autor: Nadia P. Belichenko, Pavel V. Belichenko, William C. Mobley

Publikováno v: Neurobiology of Disease, Vol 34, Iss 1, Pp 71-77 (2009)

Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by mutations in the gene MECP2, encoding methyl-CpG-binding protein 2 (MeCP2). Few studies have explored dendritic morphology phenotypes in mouse models of RTT and none have determ

Externí odkaz: https://doaj.org/article/3dcf63326232432fa9e343717d0033e3

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Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity

Autor: Izumi V. Hinkson, Jae K. Ryu, Eva Czirr, Katerina Akassoglou, Nicholas A. Castello, Sasha N. Farina, Nadia P. Belichenko, John R. Cirrito, Markus Britschgi, Kira I. Mosher, Lulin Li, Tony Wyss-Coray, Bernat Baeza-Raja, Joseph M. Castellano, Frank M. Longo, Kurt M. Lucin

Publikováno v: The Journal of Experimental Medicine

Czirr et al. report that microglia lacking complement receptor 3 display increased extracellular Aβ degrading activity and that targeting the receptor with a small molecule increases Aβ clearance in vivo, thus identifying a microglial receptor as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4076dcc33cad166602275e952ee939dd
http://europepmc.org/articles/PMC5379986

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[18F]GE-180 PET Detects Reduced Microglia Activation After LM11A-31 Therapy in a Mouse Model of Alzheimer's Disease

Autor: Paul A. Jones, Jianghong Rao, Adam J. Shuhendler, Nadia P. Belichenko, Michelle L. James, Thuy-Vi V. Nguyen, Aileen Hoehne, Lauren Andrews, Vladimer Reiser, Frank M. Longo, William Trigg, Christina Condon, Sanjiv S. Gambhir

Publikováno v: Theranostics

Microglial activation is a key pathological feature of Alzheimer's disease (AD). PET imaging of translocator protein 18 kDa (TSPO) is a strategy to detect microglial activation in vivo. Here we assessed flutriciclamide ([18F]GE-180), a new second-gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f0070e66b5a10aa504800fbd47599c3
https://doi.org/10.7150/thno.17666

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Alzheimer's associated amyloid and tau deposition co-localizes with a homeostatic myelin repair pathway in two mouse models of post-stroke mixed dementia

Autor: Thuy-Vi V. Nguyen, Jennifer B. Frye, Brian S. McKay, Nadia P. Belichenko, Jacob C. Zbesko, Frank M. Longo, Kristian P. Doyle, Megan Hayes, Nicole R. Congrove

Publikováno v: Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-25 (2018)

The goal of this study was to determine the chronic impact of stroke on the manifestation of Alzheimer’s disease (AD) related pathology and behavioral impairments in mice. To accomplish this goal, we used two distinct models. First, we experimental

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a271af6b182cc8f122c50f02aeda3a7
https://pubmed.ncbi.nlm.nih.gov/30249297

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Small Molecule p75NTR Ligands Reduce Pathological Phosphorylation and Misfolding of Tau, Inflammatory Changes, Cholinergic Degeneration, and Cognitive Deficits in AβPPL/S Transgenic Mice

Autor: Tao Yang, Frank M. Longo, Tony Wyss-Coray, Stephen M. Massa, Lisa N. Quach, Lin Shen, Nay Saw, Lilith Vander Griend, Mehrdad Shamloo, Thuy-Vi V. Nguyen, Nadia P. Belichenko

Publikováno v: Journal of Alzheimer's Disease. 42:459-483

The p75 neurotrophin receptor (p75NTR ) is involved in degenerative mechanisms related to Alzheimer’s disease (AD). In addition, p75NTR levels are increased in AD and the receptor is expressed by neurons that are particularly vulnerable in the dise

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e09ff6fb3c04101346967e03ec6f293
https://doi.org/10.3233/jad-140036

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A Small Molecule TrkB Ligand Reduces Motor Impairment and Neuropathology in R6/2 and BACHD Mouse Models of Huntington's Disease

Autor: Deqiang Jing, Marie Monbureau, Christina Condon, Nadia P. Belichenko, Stephen M. Massa, Tao Yang, Mehrdad Shamloo, Danielle A. Simmons, Frank M. Longo

Publikováno v: The Journal of Neuroscience. 33:18712-18727

Loss of neurotrophic support in the striatum caused by reduced brain-derived neurotrophic factor (BDNF) levels plays a critical role in Huntington's disease (HD) pathogenesis. BDNF acts via TrkB and p75 neurotrophin receptors (NTR), and restoring its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8080bdc09d7fed11fab0ccdbeee64a6
https://doi.org/10.1523/jneurosci.1310-13.2013

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A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice

Autor: Marie Monbureau, Christina Condon, Nadia P. Belichenko, Danielle A. Simmons, Sarah Semaan, Sruti Aiyaswamy, Stephen M. Massa, Ellen C. Ford, Frank M. Longo, Cameron M. Holman, Mehrdad Shamloo

Publikováno v: Human Molecular Genetics

Decreases in the ratio of neurotrophic versus neurodegenerative signalling play a critical role in Huntington’s disease (HD) pathogenesis and recent evidence suggests that the p75 neurotrophin receptor (NTR) contributes significantly to disease pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::475b347f95e25b447dc9f31e440f2b70
https://pubmed.ncbi.nlm.nih.gov/28171570

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Widespread changes in dendritic and axonal morphology inMecp2-mutant mouse models of rett syndrome: Evidence for disruption of neuronal networks

Autor: Eliezer Masliah, Elena E. Wright, William C. Mobley, Hong Hua Li, Pavel V. Belichenko, Nadia P. Belichenko, Uta Francke

Publikováno v: The Journal of Comparative Neurology. 514:240-258

Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the X-linked gene MECP2. Girls with RTT show dramatic changes in brain function, but relatively few studies have explored the structure of neural circuits. Examining two mous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e0a1643f029c3eda4e855fc8e14e4f
https://doi.org/10.1002/cne.22009

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