Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Nadia Moretto"'
Autor:
Cataldo Martucci, Andrew Dennis Allen, Nadia Moretto, Valentina Bagnacani, Alessandro Fioni, Riccardo Patacchini, Maurizio Civelli, Gino Villetti, Fabrizio Facchinetti
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Inhibition of p38 mitogen-activated protein kinase (MAPKs) is a potential therapeutic approach for the treatment of acute and chronic pulmonary inflammatory conditions. Here, we report the in vitro and in vivo characterization of the anti-inflammator
Externí odkaz:
https://doaj.org/article/e024c104ed8c452b84fdb9c6bcc61046
Autor:
Romina Nassini, Pamela Pedretti, Nadia Moretto, Camilla Fusi, Chiara Carnini, Fabrizio Facchinetti, Arturo Roberto Viscomi, Anna Rita Pisano, Susan Stokesberry, Charlott Brunmark, Naila Svitacheva, Lorcan McGarvey, Riccardo Patacchini, Anders B Damholt, Pierangelo Geppetti, Serena Materazzi
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42454 (2012)
BACKGROUND: The transient receptor potential ankyrin 1 (TRPA1) channel, localized to airway sensory nerves, has been proposed to mediate airway inflammation evoked by allergen and cigarette smoke (CS) in rodents, via a neurogenic mechanism. However t
Externí odkaz:
https://doaj.org/article/d4a93ac0c47b41b3a7f6c2f4bb8e3713
Autor:
Elisabetta Armani, Carmelida Capaldi, Valentina Bagnacani, Francesca Saccani, Giancarlo Aquino, Paola Puccini, Fabrizio Facchinetti, Cataldo Martucci, Nadia Moretto, Gino Villetti, Riccardo Patacchini, Maurizio Civelli, Chris Hurley, Andrew Jennings, Lilian Alcaraz, Dawn Bloomfield, Michael Briggs, Stephen Daly, Terry Panchal, Vince Russell, Sharon Wicks, Harry Finch, Mary Fitzgerald, Craig Fox, Maurizio Delcanale
Publikováno v:
Journal of Medicinal Chemistry. 65:7170-7192
The identification of novel inhaled p38α/β mitogen-activated protein kinases (MAPK) (MAPK14/11) inhibitors suitable for the treatment of pulmonary inflammatory conditions has been described. A rational drug design approach started from the identifi
Autor:
Maurizio Civelli, Alice Pappani, Paola Puccini, Elisabetta Armani, Laura Carzaniga, Silvia Catinella, Roberta Volta, Riccardo Patacchini, Gabriele Amari, Valentina Cenacchi, Maurizio Delcanale, Fabrizio Facchinetti, Chiara Carnini, Carmelida Capaldi, Silvia Capacchi, Andrea Rizzi, Gessica Marchini, Valentina Bagnacani, Gino Villetti, Nadia Moretto, Loredana Battipaglia, Paola Caruso, Francesco Amadei, Eleonora Ghidini, Fanti Renato De
Publikováno v:
Journal of Medicinal Chemistry. 60:10026-10046
Phosphodiesterase 4 (PDE4) is a key cAMP-metabolizing enzyme involved in the pathogenesis of inflammatory disease, and its pharmacological inhibition has been shown to exert therapeutic efficacy in chronic obstructive pulmonary disease (COPD). Herein
Autor:
Nadia Moretto, Carmen Parola, Valentina Salvi, Fabrizio Facchinetti, Veronica Gianello, Gino Villetti, Daniela Bosisio, Silvano Sozzani, Maurizio Civelli
Phosphodiesterase 4 (PDE4) inhibitors are used to treat autoimmune and inflammatory diseases, such as psoriasis and chronic obstructive pulmonary disease (COPD). CHF6001 is a novel, potent and selective inhaled PDE4 inhibitor in development for the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c65182414b007aa4e85bb1b2c86fa8a
http://hdl.handle.net/11573/1371424
http://hdl.handle.net/11573/1371424
Autor:
Maurizio Civelli, Carola Buccellati, Angelo Sala, Fabrizio Facchinetti, Laura Carzaniga, Eleonora Ghidini, Gabriele Amari, Fanti Renato De, Fiorella Pastore, Chiara Carnini, Paola Caruso, Maurizio Delcanale, Elisabetta Armani, Gino Villetti, Carmelida Capaldi, Riccardo Patacchini, Gessica Marchini, Andrea Rizzi, Emilio Hirsch, Raffaella Bosco, Nadia Moretto
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 352:559-567
This study examined the pharmacologic characterization of CHF6001 [(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3-(cyclopropylmethoxy)-4-(methylsulfonamido)benzoyloxy)ethyl)pyridine 1-oxide], a novel phosphodiesterase (
Publikováno v:
Annals of the New York Academy of Sciences. 1259:39-46
Acrolein (2-propenal) is a highly reactive α,β-unsaturated aldehyde and a respiratory irritant that is ubiquitously present in the environment but that can also be generated endogenously at sites of inflammation. Acrolein is abundant in tobacco smo
Publikováno v:
British Journal of Pharmacology. 163:649-661
BACKGROUND AND PURPOSE Vascular endothelial growth factor (VEGF) is an angiogenic factor known to be elevated in the sputum of asymptomatic smokers as well as smokers with bronchitis type of chronic obstructive pulmonary disease. The aim of this stud
Autor:
Thomas Southworth, Maurizio Civelli, Dave Singh, Fabrizio Facchinetti, Nadia Moretto, Riccardo Patacchini
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 296:L839-L848
Cigarette smoking is the major risk factor for chronic obstructive pulmonary disease (COPD), a syndrome characterized by pulmonary neutrophil infiltration, chronic inflammation, and progressive tissue destruction. We examined here the acute effect of
Autor:
Fabrizio Facchinetti, Simone Ottonello, Elda Del Giudice, Francesca Grassi, Paola Puccini, Gino Villetti, Roberta Volta, Alberta Leon, Bruno P. Imbimbo, Nadia Moretto, Benedetta Riccardi, Valentina Cenacchi
Publikováno v:
Pharmacological Research. 55:318-328
Long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) may delay or prevent the onset of Alzheimer's disease (AD). A subset of NSAIDs, including flurbiprofen, has been shown to selectively inhibit the production of beta-amyloid(1-42) (Abeta4