Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Nadia M, Luheshi"'
Autor:
Azar Shahraz, Mark Penney, Juliana Candido, Grace Opoku‐Ansah, Melanie Neubauer, Jim Eyles, Oluwaseun Ojo, Nelson Liu, Nadia M. Luheshi, Alex Phipps, Karthick Vishwanathan
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 10, Pp 1670-1681 (2024)
Abstract AZD0171 (INN: Falbikitug) is being developed as a humanized monoclonal antibody (mAb), immunoglobulin G subclass 1 (IgG1), which binds specifically to the immunosuppressive human cytokine leukemia inhibitory factor (LIF) and inhibits downstr
Externí odkaz:
https://doaj.org/article/654650c22c3e43b7a045471ce1fdd1d4
Autor:
Mark Austin, Daniel Burschowsky, Denice T.Y. Chan, Lesley Jenkinson, Stuart Haynes, Agata Diamandakis, Chitra Seewooruthun, Alexandra Addyman, Sebastian Fiedler, Stephanie Ryman, Jessica Whitehouse, Louise H. Slater, Andreas V. Hadjinicolaou, Uzi Gileadi, Ellen Gowans, Yoko Shibata, Michelle Barnard, Teresa Kaserer, Pooja Sharma, Nadia M. Luheshi, Robert W. Wilkinson, Tristan J. Vaughan, Sarah V. Holt, Vincenzo Cerundolo, Mark D. Carr, Maria A. T. Groves
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
Arginase 2 (ARG2) is a binuclear manganese metalloenzyme that catalyzes the hydrolysis of L-arginine. The dysregulated expression of ARG2 within specific tumor microenvironments generates an immunosuppressive niche that effectively renders the tumor
Externí odkaz:
https://doaj.org/article/e9b2ccb330b0476b8cb004d93c4045cc
Autor:
Victor S, Tapia, Michael J D, Daniels, Pablo, Palazón-Riquelme, Matthew, Dewhurst, Nadia M, Luheshi, Jack, Rivers-Auty, Jack, Green, Elena, Redondo-Castro, Philipp, Kaldis, Gloria, Lopez-Castejon, David, Brough
Publikováno v:
The Journal of Biological Chemistry
Interleukin (IL)-1 family cytokines potently regulate inflammation, with the majority of the IL-1 family proteins being secreted from immune cells via unconventional pathways. In many cases, secretion of IL-1 cytokines appears to be closely coupled t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4bc970a802f25a9a3aae02c018dda128
https://pubmed.ncbi.nlm.nih.gov/30940725
https://pubmed.ncbi.nlm.nih.gov/30940725