Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Nadia Leloup"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Type-I transmembrane proteins represent a large group of 1,412 proteins in humans with a multitude of functions in cells and tissues. They are characterized by an extracellular, or luminal, N-terminus followed by a single transmembrane helix and a cy
Externí odkaz:
https://doaj.org/article/3939649fae2e4a37bdc8f156f7725dbe
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
The Sortilin-related CNS-expressed receptor 2 (SorCS2)–proneurotrophin signaling system regulates neuronal plasticity and its dysfunction is linked to schizophrenia. Here the authors present the structures of the SorCS2 ectodomain alone and in comp
Externí odkaz:
https://doaj.org/article/a272131e31ee4e99a1f0ca5d3e9dd5cb
Autor:
Nadia Leloup, Philip Lössl, Dimphna H. Meijer, Martha Brennich, Albert J. R. Heck, Dominique M. E. Thies-Weesie, Bert J. C. Janssen
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Sortilin is an endocytosis receptor with a luminal β-propeller domain. Here the authors present the structures of the β-propeller domain at neutral and acidic pH, which reveal that sortilin dimerises and undergoes conformational changes at low pH a
Externí odkaz:
https://doaj.org/article/6012de2c7ca2445a89156e52dab21cee
Autor:
Alexis D. Corrado, Akiko Koide, Wei Zhang, Nadia Leloup, Gayatri Ketavarapu, Takamitsu Hattori, Julien Oury, Steven J. Burden, Shohei Koide
Publikováno v:
Nature. 595:404-408
Congenital myasthenia (CM) is a devastating neuromuscular disease, and mutations in DOK7, an adaptor protein that is crucial for forming and maintaining neuromuscular synapses, are a major cause of CM1,2. The most common disease-causing mutation (DOK
Autor:
Waldemar Vollmer, Eefjan Breukink, Alexander J. F. Egan, Bert J. C. Janssen, Nathaniel I. Martin, Inge L. van't Veer, Nadia Leloup
Publikováno v:
ChemBioChem. 17:2207-2207