Výsledky vyhledávání - "Nadia Ladygina"

Akademický článek

Structure of the human marker of self 5-transmembrane receptor CD47

Autor: Gustavo Fenalti, Nicolas Villanueva, Mark Griffith, Barbra Pagarigan, Sirish Kaushik Lakkaraju, Richard Y.-C. Huang, Nadia Ladygina, Alok Sharma, David Mikolon, Mahan Abbasian, Jeffrey Johnson, Haralambos Hadjivassiliou, Dan Zhu, Philip P. Chamberlain, Ho Cho, Kandasamy Hariharan

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

CD47 is a transmembrane receptor involved in the regulation of various signalling pathways and a promising target for immuno-oncology therapeutics. Here, the authors present the crystal structure of full-length human CD47 and provide insights into th

Externí odkaz: https://doaj.org/article/16ac1202277e490cac61cc68b1c66fb7

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Structure of the human marker of self 5-transmembrane receptor CD47

Autor: Philip P Chamberlain, David Mikolon, Ho Cho, Johnson Jeffrey C, Mahan Abbasian, Nadia Ladygina, Nicolas Villanueva, Hadjivassiliou Haralambos, Richard Y.-C. Huang, Gustavo Fenalti, Alok Sharma, Dan Zhu, Barbra Pagarigan, Sirish Kaushik Lakkaraju, Kandasamy Hariharan, Mark Griffith

Publikováno v: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

CD47 is the only 5-transmembrane (5-TM) spanning receptor of the immune system. Its extracellular domain (ECD) is a cell surface marker of self that binds SIRPα and inhibits macrophage phagocytosis, and cancer immuno-therapy approaches in clinical t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea8c511046adf13fd6850c565f111f03
https://doi.org/10.1038/s41467-021-25475-w

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PI3Kγ kinase activity is required for optimal T‐cell activation and differentiation

Autor: Wai-Ping Fung-Leung, Sridevi Gottipati, Nadia Ladygina, Homayon Banie, Tadimeti S. Rao, Glenda Castro, Jing‐Ying Ma, Karen Ngo

Publikováno v: European Journal of Immunology

Phosphatidylinositol-3-kinase gamma (PI3Kγ) is a leukocyte-specific lipid kinase with signaling function downstream of G protein-coupled receptors to regulate cell trafficking, but its role in T cells remains unclear. To investigate the requirement

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ab189ab0c7c16d9836193c125200ea9
https://doi.org/10.1002/eji.201343812

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