Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Nadia Keller"'
Autor:
Andre Mu, William P. Klare, Sarah L. Baines, C. N. Ignatius Pang, Romain Guérillot, Nichaela Harbison-Price, Nadia Keller, Jonathan Wilksch, Nguyen Thi Khanh Nhu, Minh-Duy Phan, Bernhard Keller, Brunda Nijagal, Dedreia Tull, Saravanan Dayalan, Hwa Huat Charlie Chua, Dominik Skoneczny, Jason Koval, Abderrahman Hachani, Anup D. Shah, Nitika Neha, Snehal Jadhav, Sally R. Partridge, Amanda J. Cork, Kate Peters, Olivia Bertolla, Stephan Brouwer, Steven J. Hancock, Laura Álvarez-Fraga, David M. P. De Oliveira, Brian Forde, Ashleigh Dale, Warasinee Mujchariyakul, Calum J. Walsh, Ian Monk, Anna Fitzgerald, Mabel Lum, Carolina Correa-Ospina, Piklu Roy Chowdhury, Robert G. Parton, James De Voss, James Beckett, Francois Monty, Jessica McKinnon, Xiaomin Song, John R. Stephen, Marie Everest, Matt I. Bellgard, Matthew Tinning, Michael Leeming, Dianna Hocking, Leila Jebeli, Nancy Wang, Nouri Ben Zakour, Serhat A. Yasar, Stefano Vecchiarelli, Tonia Russell, Thiri Zaw, Tyrone Chen, Don Teng, Zena Kassir, Trevor Lithgow, Adam Jenney, Jason N. Cole, Victor Nizet, Tania C. Sorrell, Anton Y. Peleg, David L. Paterson, Scott A. Beatson, Jemma Wu, Mark P. Molloy, Anna E. Syme, Robert J. A. Goode, Adam A. Hunter, Grahame Bowland, Nicholas P. West, Marc R. Wilkins, Steven P. Djordjevic, Mark R. Davies, Torsten Seemann, Benjamin P. Howden, Dana Pascovici, Sonika Tyagi, Ralf B. Schittenhelm, David P. De Souza, Malcolm J. McConville, Jonathan R. Iredell, Stuart J. Cordwell, Richard A. Strugnell, Timothy P. Stinear, Mark A. Schembri, Mark J. Walker
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Severe sepsis has a high mortality rate. Here, the authors provide genomic, transcriptomic, proteomic and metabolomic data across four sepsis-causing pathogens and identify a signature of global increase in fatty acid and lipid biosynthesis as well a
Externí odkaz:
https://doaj.org/article/6d65b18b91de403488fe5eca204df6be
Autor:
Mark R. Davies, Nadia Keller, Stephan Brouwer, Magnus G. Jespersen, Amanda J. Cork, Andrew J. Hayes, Miranda E. Pitt, David M. P. De Oliveira, Nichaela Harbison-Price, Olivia M. Bertolla, Daniel G. Mediati, Bodie F. Curren, George Taiaroa, Jake A. Lacey, Helen V. Smith, Ning-Xia Fang, Lachlan J. M. Coin, Kerrie Stevens, Steven Y. C. Tong, Martina Sanderson-Smith, Jai J. Tree, Adam D. Irwin, Keith Grimwood, Benjamin P. Howden, Amy V. Jennison, Mark J. Walker
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
A variant of group A Streptococcus serotype M1 (UK) has been increasingly reported and can be differentiated from the global variant by its overexpression of the superantigen SpeA. Here, Davies et al probe the mechanism behind enhanced SpeA expressio
Externí odkaz:
https://doaj.org/article/c8e8696ec17643b4a4f2990cdf959bbe
Autor:
David M. P. De Oliveira, Brian M. Forde, Minh-Duy Phan, Bernhard Steiner, Bing Zhang, Johannes Zuegg, Ibrahim M. El-deeb, Gen Li, Nadia Keller, Stephan Brouwer, Nichaela Harbison-Price, Amanda J. Cork, Michelle J. Bauer, Saleh F. Alquethamy, Scott A. Beatson, Jason A. Roberts, David L. Paterson, Alastair G. McEwan, Mark A. T. Blaskovich, Mark A. Schembri, Christopher A. McDevitt, Mark von Itzstein, Mark J. Walker
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT Acinetobacter baumannii causes high mortality in ventilator-associated pneumonia patients, and antibiotic treatment is compromised by multidrug-resistant strains resistant to β-lactams, carbapenems, cephalosporins, polymyxins, and tetracycl
Externí odkaz:
https://doaj.org/article/8f2bdff572bc4d56b1b341ed52eaa3c2
Autor:
David M. P. De Oliveira, Bernhard Keller, Andrew J. Hayes, Cheryl-Lynn Y. Ong, Nichaela Harbison-Price, Ibrahim M. El-Deeb, Gen Li, Nadia Keller, Lisa Bohlmann, Stephan Brouwer, Andrew G. Turner, Amanda J. Cork, Thomas R. Jones, David L. Paterson, Alastair G. McEwan, Mark R. Davies, Christopher A. McDevitt, Mark von Itzstein, Mark J. Walker
Publikováno v:
Antibiotics, Vol 11, Iss 4, p 449 (2022)
Gram-positive bacteria do not produce lipopolysaccharide as a cell wall component. As such, the polymyxin class of antibiotics, which exert bactericidal activity against Gram-negative pathogens, are ineffective against Gram-positive bacteria. The saf
Externí odkaz:
https://doaj.org/article/1be6b9530c0b43719c05faf3da6a377f
Autor:
Johan Seijsing, Anna M. Sobieraj, Nadia Keller, Yang Shen, Annelies S. Zinkernagel, Martin J. Loessner, Mathias Schmelcher
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
The increasing number of multidrug-resistant bacteria intensifies the need to develop new antimicrobial agents. Endolysins are bacteriophage-derived enzymes that degrade the bacterial cell wall and hold promise as a new class of highly specific and v
Externí odkaz:
https://doaj.org/article/7208ba3a8031415ca4ff598cb3fc9bc9
Autor:
Ann E. Lin, Federico C. Beasley, Nadia Keller, Andrew Hollands, Rodolfo Urbano, Emily R. Troemel, Hal M. Hoffman, Victor Nizet
Publikováno v:
mBio, Vol 6, Iss 2 (2015)
ABSTRACT The M1T1 clone of group A Streptococcus (GAS) is associated with severe invasive infections, including necrotizing fasciitis and septicemia. During invasive M1T1 GAS disease, mutations in the covRS regulatory system led to upregulation of an
Externí odkaz:
https://doaj.org/article/1ae0b0c745294a0da11db658350bbcde
Autor:
Ann E Lin, Federico C Beasley, Joshua Olson, Nadia Keller, Robert A Shalwitz, Thomas J Hannan, Scott J Hultgren, Victor Nizet
Publikováno v:
PLoS Pathogens, Vol 11, Iss 4, p e1004818 (2015)
Uropathogenic E. coli (UPEC) is the primary cause of urinary tract infections (UTI) affecting approximately 150 million people worldwide. Here, we revealed the importance of transcriptional regulator hypoxia-inducible factor-1 α subunit (HIF-1α) in
Externí odkaz:
https://doaj.org/article/db10f08b193f496fb43608ee76bb7be3
Autor:
Nadia Keller, Mathilde Boumasmoud, Federica Andreoni, Andrea Tarnutzer, Manuela von Matt, Thomas C. Scheier, Alejandro Gómez-Mejia, Markus Huemer, Ewerton Marques-Maggio, Reto A. Schuepbach, Srikanth Mairpady-Shambat, Silvio D. Brugger, Annelies S. Zinkernagel
ObjectivesGroup AStreptococcus(GAS) necrotizing fasciitis (NF) is a difficult-to-treat bacterial infection associated with high morbidity and mortality despite extensive surgery and targeted antibiotic treatment. Bacteria surviving prolonged antibiot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5701944f493ec0d17d23c157b2dc968
https://doi.org/10.1101/2022.08.19.504414
https://doi.org/10.1101/2022.08.19.504414
Autor:
Alastair G. McEwan, Mark A. Schembri, Freda E.-C. Jen, Gregory M. Cook, Timothy J. Kidd, Mark J. Walker, Christopher A. McDevitt, Jake A. Lacey, Ibrahim M. El-Deeb, Trent Conroy, Brian M. Forde, Scott A. Beatson, David L. Paterson, Minh-Duy Phan, Mark von Itzstein, Karl A. Hansford, Michelle J Bauer, Nadia Keller, Lisa Bohlmann, Raghu Bolisetti, Jian Li, Arun V. Everest-Dass, Michael P. Jennings, Aimee Tan, Mark A. T. Blaskovich, Stephan Brouwer, Tania Rivera-Hernandez, Amanda J. Cork, David M. P. De Oliveira, Mark R. Davies
Publikováno v:
Science translational medicine. 12(570)
The emergence of polymyxin resistance in carbapenem-resistant and extended-spectrum β-lactamase (ESBL)-producing bacteria is a critical threat to human health, and alternative treatment strategies are urgently required. We investigated the ability o
Autor:
Federica Andreoni, Annelies S. Zinkernagel, Nadia Keller, Anna Norrby-Teglund, Alexander A. Tarnutzer, Claudia Zürcher, Reto Schüpbach
Objectives Streptococcus pyogenes causes life-threatening invasive infections including necrotizing fasciitis (NF). Current treatment guidelines recommend the use of a cell-wall–active antibiotic combined with a protein synthesis inhibitor and surg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61f5969ddf73cdf70637a70c469b7ced
https://doi.org/10.5167/uzh-153627
https://doi.org/10.5167/uzh-153627