Zobrazeno 1 - 10
of 1 403
pro vyhledávání: '"Nadia J"'
Autor:
Ethan P. Oxley, Nadia J. Kershaw, Cynthia Louis, Katharine J. Goodall, Maximilian M. Garwood, Skye Min Jee Ho, Veronica T.F. Voo, Hae-Young Park, Josephine Iaria, Lilian L.L. Wong, Ariel G. Lebenbaum, Stephanie Wiranata, Ee Shan Pang, Emily S.J. Edwards, Damian B. D’Silva, Jacinta Hansen, Menno C. van Zelm, Meredith O’Keeffe, P. Mark Hogarth, Nicole M. Haynes, Nicholas D. Huntington, Ian P. Wicks, Ross A. Dickins
Publikováno v:
Cell Reports, Vol 43, Iss 10, Pp 114834- (2024)
Summary: T cell surface CTLA4 sequesters the costimulatory ligands CD80 and CD86 on antigen-presenting cells (APCs) to prevent autoimmunity. Therapeutic immunosuppression by recombinant CTLA4-immunoglobulin (Ig) fusion proteins, including abatacept,
Externí odkaz:
https://doaj.org/article/6c8609b2d6c447c2abb2c3c69d1e33ba
Autor:
Kaiseal T. G. Sarson-Lawrence, Joshua M. Hardy, Josephine Iaria, Dina Stockwell, Kira Behrens, Tamanna Saiyed, Cyrus Tan, Leila Jebeli, Nichollas E. Scott, Toby A. Dite, Nicos A. Nicola, Andrew P. Leis, Jeffrey J. Babon, Nadia J. Kershaw
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Thrombopoietin (Tpo) is the primary regulator of megakaryocyte and platelet numbers and is required for haematopoetic stem cell maintenance. Tpo functions by binding its receptor (TpoR, a homodimeric Class I cytokine receptor) and initiating
Externí odkaz:
https://doaj.org/article/90ff36cf97bf40a595fd54f4fb808af6
Autor:
Héctor Herrera-Orozco, Verónica García-Castillo, Eduardo López-Urrutia, Antonio Daniel Martinez-Gutierrez, Eloy Pérez-Yepez, Oliver Millán-Catalán, David Cantú de León, César López-Camarillo, Nadia J. Jacobo-Herrera, Mauricio Rodríguez-Dorantes, Rosalío Ramos-Payán, Carlos Pérez-Plasencia
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 12, Pp 9549-9565 (2023)
Colorectal cancer (CRC) represents the second deadliest malignancy worldwide. Around 75% of CRC patients exhibit high levels of chromosome instability that result in the accumulation of somatic copy number alterations. These alterations are associate
Externí odkaz:
https://doaj.org/article/b1802939daaf41058e4b16337465248c
Autor:
Shuwei Liang, Eric Tran, Xin Du, Jiajun Dong, Harrison Sudholz, Hao Chen, Zihan Qu, Nicholas D. Huntington, Jeffrey J. Babon, Nadia J. Kershaw, Zhong-Yin Zhang, Jonathan B. Baell, Florian Wiede, Tony Tiganis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-27 (2023)
Abstract The inhibition of protein tyrosine phosphatases 1B (PTP1B) and N2 (PTPN2) has emerged as an exciting approach for bolstering T cell anti-tumor immunity. ABBV-CLS-484 is a PTP1B/PTPN2 inhibitor in clinical trials for solid tumors. Here we hav
Externí odkaz:
https://doaj.org/article/0cb5e14e733040fe85a8642c25963be7
Autor:
Rhiannon Morris, Narelle Keating, Cyrus Tan, Hao Chen, Artem Laktyushin, Tamanna Saiyed, Nicholas P. D. Liau, Nicos A. Nicola, Tony Tiganis, Nadia J. Kershaw, Jeffrey J. Babon
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract Protein Tyrosine Phosphatase 1B (PTP1B) is the prototypical protein tyrosine phosphatase and plays an essential role in the regulation of several kinase-driven signalling pathways. PTP1B displays a preference for bisphosphorylated substrates
Externí odkaz:
https://doaj.org/article/fe7ce3bae9694500a0f1ccbffabd3899
Autor:
Larissa L.S. Scholte, David J. Leggat, Kristen W. Cohen, Lara Hoeweler, Guacyara C. Erwin, Farhard Rahaman, Angela Lombardo, Vincent Philiponis, Dagna S. Laufer, Heather Siefers, Alexis M. Ruppel, Joshua Brand, Janine Maenza, Rhi Bronson, Madhu Prabhakaran, Jalen Jean-Baptiste, Orpheus Kolokythas, Aimee A. Desrosiers, Caroline K. Thoreson, Antje Heit, Nadia J. Khati, Elissa Malkin, M. Juliana McElrath, Adrian B. McDermott, William R. Schief, David Diemert, Jeffrey M. Bethony
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102576- (2023)
Summary: The lymph node (LN) is a critical biological site for immune maturation after vaccination as it includes several cell populations critical for priming the antibody response. Here, we present a protocol for sampling the LN and isolating cell
Externí odkaz:
https://doaj.org/article/35d5c65745b04af5bc934414faf8dd90
Autor:
Irma B. Mitre-Aguilar, Daniel Moreno-Mitre, Jorge Melendez-Zajgla, Vilma Maldonado, Nadia J. Jacobo-Herrera, Victoria Ramirez-Gonzalez, Gretel Mendoza-Almanza
Publikováno v:
Current Oncology, Vol 30, Iss 1, Pp 298-314 (2022)
Glucocorticoids (GCs) are anti-inflammatory and immunosuppressive steroid molecules secreted by the adrenal gland and regulated by the hypothalamic–pituitary–adrenal (HPA) axis. GCs present a circadian release pattern under normal conditions; the
Externí odkaz:
https://doaj.org/article/9959425fed1a4414ae3e3c48792fb082
Autor:
Fatima Alnaimat, Nadia J. Sweis, Jaleel Jerry G. Sweis, Christian Ascoli, Peter Korsten, Israel Rubinstein, Nadera J. Sweiss
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
Externí odkaz:
https://doaj.org/article/06e188c5f79247dd88d82add660b24f4
Autor:
Edmond M. Linossi, Kunlun Li, Gianluca Veggiani, Cyrus Tan, Farhad Dehkhoda, Colin Hockings, Dale J. Calleja, Narelle Keating, Rebecca Feltham, Andrew J. Brooks, Shawn S. Li, Sachdev S. Sidhu, Jeffrey J. Babon, Nadia J. Kershaw, Sandra E. Nicholson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/3771a83e093b48e7a5c69cac8e14f288
Publikováno v:
SA Journal of Human Resource Management, Vol 21, Iss 0, Pp e1-e11 (2023)
Orientation: Learnerships has been operationalised in South Africa as part of the National Skills Development Strategy (NSDS). The success of a learnership programme is influenced by stakeholder involvement. Research purpose: This study set out to e
Externí odkaz:
https://doaj.org/article/21610cef5e074df3ae71f69faee86b04