Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Nadia I. Georgieva"'
Autor:
James A. Swenberg, Vernon E. Walker, Yutai Li, Karupiah Jayaraj, Patricia B. Upton, Nadia I. Georgieva, Gunnar Boysen
1,3-Butadiene is an important industrial chemical used in the production of synthetic rubber and is also found in gasoline and combustion products. It is a multispecies, multisite carcinogen in rodents, with mice being the most sensitive species. 1,3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f309f151862cccc299191958738b4d0
https://doi.org/10.1158/0008-5472.c.6493818.v1
https://doi.org/10.1158/0008-5472.c.6493818.v1
Autor:
James A. Swenberg, Vernon E. Walker, Yutai Li, Karupiah Jayaraj, Patricia B. Upton, Nadia I. Georgieva, Gunnar Boysen
Supplementary Table 1 from Analysis of Diepoxide-Specific Cyclic N-Terminal Globin Adducts in Mice and Rats after Inhalation Exposure to 1,3-Butadiene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f29e0921f29abf68c8efa001cf3e8cb
https://doi.org/10.1158/0008-5472.22363647
https://doi.org/10.1158/0008-5472.22363647
Publikováno v:
Toxicological Sciences. 115:322-329
1,3-Butadiene (BD) is a known rodent and human carcinogen that is metabolized mainly by P450 2E1 to three epoxides, 1,2-epoxy-3-butene (EB), 1,2:3,4-diepoxybutane (DEB), and 1,2-epoxy-3,4-butanediol. The individual epoxides vary up to 200-fold in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab7972fab6747d72f42938001ca85249
https://doi.org/10.1093/toxsci/kfq060
https://doi.org/10.1093/toxsci/kfq060
Publikováno v:
Chemico-Biological Interactions. 166:78-83
The 2005 International Symposium on the evaluation of butadiene and chloroprene health risks provided the opportunity to consider the past, present and future state of research issues for 1,3-butadiene. Considerable advancements have been made in our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71ef9149356cc71e7ed96358dd10680a
https://doi.org/10.1016/j.cbi.2007.01.012
https://doi.org/10.1016/j.cbi.2007.01.012
Publikováno v:
Chemico-Biological Interactions. 166:84-92
The aim of this review is to summarize our recent data on butadiene (BD) derived hemoglobin adducts as biomarkers for the internal formation of the individual epoxides formed by butadiene (BD). It is well known that BD is oxidized by cytochrome P450s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d59ded4749ce471ee5d48d30cb71cb1
https://doi.org/10.1016/j.cbi.2006.10.005
https://doi.org/10.1016/j.cbi.2006.10.005
Publikováno v:
Toxicology. 313(2-3)
Humans are constantly exposed to mixtures, such as tobacco smoke, exhaust from diesel, gasoline or new bio-fuels, containing several thousand compounds, including many known human carcinogens. Covalent binding of reactive compounds or their metabolit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb44e7f35fada6830ef1537a146d2cc
https://pubmed.ncbi.nlm.nih.gov/23219592
https://pubmed.ncbi.nlm.nih.gov/23219592
Autor:
Radim J. Sram, Narisa K. Bordeerat, Pamela M. Vacek, Nadia I. Georgieva, Richard J. Albertini, James A. Swenberg, Gunnar Boysen
1,3-Butadiene (BD) is an important industrial chemical that is classified as a human carcinogen. BD carcinogenicity has been attributed to its metabolism to several reactive epoxide metabolites and formation of the highly mutagenic 1,2:3,4-diepoxybut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1a748d3b9db4a14f9c5b26188f59a6c
https://europepmc.org/articles/PMC3243749/
https://europepmc.org/articles/PMC3243749/
Autor:
Hasan Koc, Daping Zhang, Ramiah Sangaiah, Bernard T. Golding, Gunnar Boysen, James A. Swenberg, Avram Gold, Petra Begemann, Karl M. Koshlap, Nadia I. Georgieva
Publikováno v:
Chemical research in toxicology. 24(7)
Isoprene, the 2-methyl analogue of 1,3-butadiene, is ubiquitous in the environment, with major contributions to total isoprene emissions stemming from natural processes despite the compound being a bulk industrial chemical. Additionally, isoprene is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09ee397558afffee8e074c56692cfe5e
https://pubmed.ncbi.nlm.nih.gov/21548641
https://pubmed.ncbi.nlm.nih.gov/21548641
Autor:
Nadia I. Georgieva, Pamela M. Vacek, Natalia Y. Tretyakova, Radim J. Sram, Sujey Carro, Jun Nakamura, John M. Troutman, James A. Swenberg, Gunnar Boysen, Vernon E. Walker, Melissa Goggin, Narisa K. Bordeerat, Patricia B. Upton, Richard J. Albertini
1,3-Butadiene (BD) is a known rodent and human carcinogen that is metabolized mainly by P450 2E1 to three epoxides, 1,2-epoxy-3-butene (EB), 1,2:3,4-diepoxybutane (DEB) and 1,2-epoxy-3,4-butanediol (EB-diol). The individual epoxides vary up to 200-fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc20088425a6cc39ae07e8524b1fdc8c
Autor:
David G. Klapper, Narisa K. Bordeerat, Leonard B. Collins, James A. Swenberg, Gunnar Boysen, Nadia I. Georgieva, Christoph H. Borchers, Tyra J. Cross
Mass spectrometry-based proteomics has become an indispensable tool in system biology generating a need for accurate and precise quantitation of peptide standards. The presented method utilizes ultra performance liquid chromatography-tandem mass spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf4580991e91fa079543d86c783f940
https://europepmc.org/articles/PMC2766299/
https://europepmc.org/articles/PMC2766299/