Výsledky vyhledávání - "Nadia H Martins"

Akademický článek

Insights into phosphate cooperativity and influence of substrate modifications on binding and catalysis of hexameric purine nucleoside phosphorylases.

Autor: Priscila O de Giuseppe, Nadia H Martins, Andreia N Meza, Camila R dos Santos, Humberto D'Muniz Pereira, Mario T Murakami

Publikováno v: PLoS ONE, Vol 7, Iss 9, p e44282 (2012)

The hexameric purine nucleoside phosphorylase from Bacillus subtilis (BsPNP233) displays great potential to produce nucleoside analogues in industry and can be exploited in the development of new anti-tumor gene therapies. In order to provide structu

Externí odkaz: https://doaj.org/article/0f657b0966b244129a113bd1b491d185

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Effectiveness of commercial inhibitors against subtype F HIV-1 protease

Autor: Igor Polikarpov, Nadia H. Martins, Sandra Krauchenco, Mário Antônio Sanches

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Subtype F wild type HIV protease has been kinetically characterized using six commercial inhibitors (amprenavir, indinavir, lopinavir, nelfinavir, ritonavir and saquinavir) commonly used for HIV/AIDS treatment, as well as inhibitor TL-3 and acetyl-pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f34974e6a77d73ec57e1666162b1cf0
https://doi.org/10.1080/14756360802321740

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Structural Analysis of an Echinococcus granulosus Actin-Fragmenting Protein by Small-Angle X-Ray Scattering Studies and Molecular Modeling

Autor: Nadia H. Martins, Arnaldo Zaha, Igor Polikarpov, Eliana D. Grimm, Henrique Bunselmeyer Ferreira, Rodrigo Villares Portugal, Mario de Oliveira Neto

Publikováno v: Biophysical Journal. 90:3216-3223

The Echinococcus granulosus actin filament-fragmenting protein (EgAFFP) is a three domain member of the gelsolin family of proteins, which is antigenic to human hosts. These proteins, formed by three or six conserved domains, are involved in the dyna

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f73e1c3957e1fd3110084bdf7e2ad14a
https://doi.org/10.1529/biophysj.105.067801

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Structural characterization of B and non-B subtypes of HIV-protease: insigths into the natural susceptibility to drug resistance development

Autor: Alla Gustchina, Alexander Wlodawer, Mário Antônio Sanches, Igor Polikarpov, Sandra Krauchenco, Nadia H. Martins

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Although a majority of HIV-1 infections in Brazil are caused by the subtype B virus (also prevalent in the United States and Western Europe), viral subtypes F and C are also found very frequently. Genomic differences between the subtypes give rise to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af44b5e823fb067f84c78d67522b0db7

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Crystallization of a non-B and a B mutant HIV protease

Autor: Igor Polikarpov, Amilcar Tanuri, Rodrigo Brindeiro, Nadia H. Martins, Alexandre R. Calazans, Mário Antônio Sanches, Octavio A. C. Antunes

Publikováno v: Acta crystallographica. Section D, Biological crystallography. 60(Pt 9)

HIV polymorphism is responsible for the selection of variant viruses resistant to inhibitors used in AIDS treatment. Knowledge of the mechanism of resistance of those viruses is determinant to the development of new inhibitors able to stop, or at lea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4090f521a66814c4f26332bc9633a9b7
https://pubmed.ncbi.nlm.nih.gov/15333937

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