Different susceptibility to the Parkinson's toxin MPTP in mice lacking the redox master regulator Nrf2 or its target gene heme oxygenase-1.

Autor: Nadia G Innamorato, Agnieszka Jazwa, Ana I Rojo, Concepción García, Javier Fernández-Ruiz, Anna Grochot-Przeczek, Anna Stachurska, Alicja Jozkowicz, Jozef Dulak, Antonio Cuadrado

Publikováno v: PLoS ONE, Vol 5, Iss 7, p e11838 (2010)

The transcription factor Nrf2 (NF-E2-related factor 2) and its target gene products, including heme oxygenase-1 (HO-1), elicit an antioxidant response that may have therapeutic value for Parkinson's disease (PD). However, HO-1 protein levels are incr

Externí odkaz: https://doaj.org/article/237962fa790f4612901e768c53a7dc3e

Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/β-TrCP Axis

Autor: Patricia Rada, Ana I. Rojo, Nathalie Evrard-Todeschi, Nadia G. Innamorato, Axelle Cotte, Tomasz Jaworski, Julio C. Tobón-Velasco, Herman Devijver, María Flor García-Mayoral, Fred Van Leuven, John D. Hayes, Gildas Bertho, Antonio Cuadrado

Publikováno v: Biblos-e Archivo. Repositorio Institucional de la UAM
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The transcription factor NF-E2-related factor 2 (Nrf2) is a master regulator of a genetic program, termed the phase 2 response, that controls redox homeostasis and participates in multiple aspects of physiology and pathology. Nrf2 protein stability i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbfe319bf84745853a3bc5708dbf1498
https://doi.org/10.1128/mcb.00180-12

α-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease

Autor: Isabel Lastres-Becker, Alberto Rábano, Antonio Cuadrado, Nadia G. Innamorato, Ayse Ulusoy, Deniz Kirik, Gurdal Sahin

Publikováno v: Human molecular genetics 21(14), 3173-3192 (2012). doi:10.1093/hmg/dds143
Human Molecular Genetics; Vol 21
Digital.CSIC. Repositorio Institucional del CSIC
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Human Molecular Genetics; 21(14), pp 3173-3192 (2012)

Although α-synuclein (α-SYN) aggregation is a hallmark of sporadic and familial Parkinson's disease (PD), it is not known how it contributes to early events of PD pathogenesis such as oxidative and inflammatory stress. Here, we addressed this quest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc84090c86482174e3e669ff9fd4921
https://pub.dzne.de/record/136563

Pharmacological targeting of the transcription factor Nrf2 at the basal ganglia provides disease modifying therapy for experimental parkinsonism

Autor: Ana I. Rojo, Antonio Cuadrado, Marlen Hesse, Agnieszka Jazwa, Nadia G. Innamorato, Javier Fernández-Ruiz

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Biblos-e Archivo. Repositorio Institucional de la UAM

Current therapies for motor symptoms of Parkinson's disease (PD) are based on dopamine replacement. However, the disease progression remains unaffected, because of continuous dopaminergic neuron loss. Since oxidative stress is actively involved in ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74da923da8ce2d2e6634cb8317363531
https://doi.org/10.1089/ars.2010.3731

Different susceptibility to the Parkinson's toxin MPTP in mice lacking the redox master regulator Nrf2 or its target gene heme oxygenase-1

Autor: Javier Fernández-Ruiz, Antonio Cuadrado, Nadia G. Innamorato, Alicja Jozkowicz, Concepción García, Ana I. Rojo, Anna Grochot Przeczek, Agnieszka Jazwa, Anna Stachurska, Jozef Dulak

Publikováno v: PLoS ONE, Vol 5, Iss 7, p e11838 (2010)
PLoS ONE
Digital.CSIC. Repositorio Institucional del CSIC
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This is an open-access article distributed under the terms of the Creative Commons Attribution License.-- et al.
[Background]: The transcription factor Nrf2 (NF-E2-related factor 2) and its target gene products, including heme oxygenase-1 (HO-1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b61d6343146a5530a682c63d80da7b59
http://europepmc.org/articles/PMC2911386?pdf=render