A review on lipid and polymeric nano-based 17-β-estradiol delivery systems: advances and challenges

Autor: Mayara Munhoz de Assis Ramos, Fernanda Yamamoto Ricardo-da-Silva, Luiza de Oliveira Macedo, Cristiano Jesus Correia, Luiz Felipe Pinho Moreira, Raimar Löbenberg, Ana Cristina Breithaupt-Faloppa, Nadia Bou-Chacra

Publikováno v: Journal of Pharmacy & Pharmaceutical Sciences, Vol 27 (2024)

17β-estradiol (E2) is an endogenous steroid hormone pivotal for the development of female secondary sexual characteristics and the maintenance of the female reproductive system. Its roles extend beyond these physiological functions, as E2 is employe

Externí odkaz: https://doaj.org/article/c9ea0bbb8f964e8dab595db255a4dc7d

Simulated Lymphatic Fluid for In-Vitro Assessment in Pharmaceutical Development

Autor: Malaz Yousef, Chulhun Park, Tyson S. Le, Nadia Bou Chacra, Neal M. Davies, Raimar Löbenberg

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d9fe4fbeff2896f919cb01bda7fbc25
https://doi.org/10.14227/dt290222p86

Biphasic Dissolution as an Exploratory Method during Early Drug Product Development

Autor: Daniela Amaral Silva, Jozef Al-Gousous, Neal M. Davies, Nadia Bou Chacra, Gregory K. Webster, Elke Lipka, Gordon L. Amidon, Raimar Löbenberg

Publikováno v: Pharmaceutics, Vol 12, Iss 5, p 420 (2020)

Dissolution testing is a major tool used to assess a drug product’s performance and as a quality control test for solid oral dosage forms. However, compendial equipment and methods may lack discriminatory power and the ability to simulate aspects o

Externí odkaz: https://doaj.org/article/95601e7b79904e82aa44db104dba1221

Synthesis, Characterization, and Activity of Hydroxymethylnitrofurazone Nanocrystals against Trypanosoma cruzi and Leishmania spp

Autor: Cauê Scarim, Aline de Souza, Débora Marins, Elda Santos, Lívia de Figueiredo Diniz Castro, Ivo Caldas, Patrícia Espuri, Marcos Marques, Elizabeth Ferreira, Nadia Bou-Chacra, Chung Chin

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Drugs and Drug Candidates; Volume 1; Issue 1; Pages: 43-55

Hydroxymethylnitrofurazone (NFOH) is a prodrug of nitrofurazone devoid of mutagenic toxicity, with in vitro and in vivo activity against Trypanosoma cruzi (T. cruzi) and in vitro activity against Leishmania. In this study, we aimed to increase the so

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a12f4471e4614c7add59e2860d1d9942

Design Space Approach for Preservative System Optimization of an Anti-Aging Eye Fluid Emulsion

Autor: Felipe Rebello Lourenço, Fabiane Lacerda Francisco, Márcia Regina Spuri Ferreira, Terezinha de Jesus Andreoli, Raimar Löbenberg, Nádia Bou-Chacra

Publikováno v: Journal of Pharmacy & Pharmaceutical Sciences, Vol 18, Iss 3 (2015)

The use of preservatives must be optimized in order to ensure the efficacy of an antimicrobial system as well as the product safety. Despite the wide variety of preservatives, the synergistic or antagonistic effects of their combinations are not well

Externí odkaz: https://doaj.org/article/9a322115c8ae4dd895475b57e55db0b6