Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Nadia Babaa"'
Autor:
Caterina Facchin, Ana B. Fraga-Timiraos, Julie Schmitt, Nadia Babaa, Naveet Pannu, Antonio Aliaga, Anne-Laure Larroque, Bertrand J. Jean-Claude
Publikováno v:
Cells, Vol 12, Iss 6, p 914 (2023)
Background: ZR2002 is a dual EGFR-DNA-targeting combi-molecule that carries a chloroethyl group at the six-position of the quinazoline ring designed to alkylate DNA. Despite its good pharmacokinetics, ZR2002 is metabolized in vivo into dechlorinated
Externí odkaz:
https://doaj.org/article/bab38f54266047238e6fe55c77e6e168
Autor:
Caterina Facchin, Ana Belen Fraga Timiraos, Brian Meehan, Nadia Babaa, Lata Adnani, Anne-Laure Larroque, Janusz Rak, Bertrand J Jean-Claude
Publikováno v:
Cancer Research. 83:1647-1647
Introduction. Glioblastoma multiforme (GBM) is the most aggressive form of primary brain tumours with an average survival rate of 12-18 months. The existing treatment (chemotherapy with temozolomide (TMZ)+radiotherapy) increases the median survival b