Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Nadia Aithmitti"'
Autor:
Angie C.A. Chiang, Nadia Aithmitti, Joanna L. Jankowsky, Alexandra Litvinchuk, Hui Zheng, Hong Lian
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 36(2)
Increasing evidence supports a role of neuroinflammation in the pathogenesis of Alzheimer's disease (AD). Previously, we identified a neuron–glia signaling pathway whereby Aβ acts as an upstream activator of astroglial nuclear factor kappa B (NF-
A critical role of the amyloid precursor protein (APP) in Alzheimer's disease (AD) pathogenesis has been well established. However, the physiological function of APP remains elusive and much debated. We reported previously that the APP family of prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f4c061b2e31585f2245a95dd0515875
https://europepmc.org/articles/PMC2757256/
https://europepmc.org/articles/PMC2757256/
Publikováno v:
The Journal of biological chemistry. 277(25)
Neuronal cell death after DNA damage requires p53 and Bax, but the mechanism by which p53 activation leads to Bax translocation and cell death in neurons is not known. We report here that Peg3/Pw1 is up-regulated after DNA damage in cortical neurons
Autor:
Serge Y. Fuchs, Hua Lu, Lois Resnick-Silverman, Yahong Lin, Nadia Aithmitti, Ze'ev Ronai, Thomas Buschmann, James J. Manfredi, Xiangwei Wu
Publikováno v:
The Journal of biological chemistry. 276(17)
Regulation of the stability of p53 is key to its tumor-suppressing activities. mdm2 directly binds to the amino-terminal region of p53 and targets it for degradation through the ubiquitin-proteasome pathway. The coactivator protein TAF(II)31 binds to