Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Nadia Abdel Wahab"'
Publikováno v:
Biochemical Journal. 406:131-138
Activated mesangial cells are thought to play a pivotal role in the development of kidney fibrosis under chronic pathological conditions, including DN (diabetic nephropathy). Their prolonged survival may enhance the development of the disease since t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a03a1e89e377153e5eac16a967072fc
https://doi.org/10.1042/bj20061817
https://doi.org/10.1042/bj20061817
Autor:
Sara Conti, Masao Masui, G. Li Volti, Roger M. Mason, Giuseppe Remuzzi, Rossella Bianchi, Martin Petrucci, Marco Campana, Luigi Fabrizio Rodella, Masashi Ito, Ariela Benigni, Nadia Abdel Wahab, Shan Yan Lin, Diego Gazzolo, Hideki Tanioka, Roberto Motterlini, Steve Ledbetter, Daniela Corna, C. Di Giacomo, Yves Paquette, François A. Leblond, Elena Gagliardini, Hui Lin, Toshihiro Shinosaki, Alain Bonnardeaux, Daniela Rottoli, Xiang Ming Qi, Elisa Borsani, Yong Gui Wu, Guo Zhong Wu, Masashi Nishida, Rita Rezzani, Carla Zoja, Mitsuru Notoya, Vincent Pichette, Ji Jia Shen, Takayuki Kuroda, Fabio Sangalli, Kenji Hamaoka
Publikováno v:
Nephron Experimental Nephrology. 104:e185-e188
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ac67c944e4fed572093116ffe019bf0
https://doi.org/10.1159/000097729
https://doi.org/10.1159/000097729
Autor:
Roger M. Mason, Nadia Abdel Wahab
Publikováno v:
Nephron Experimental Nephrology. 104:e129-e134
In the adult kidney, the cellular phenotypes are maintained by a strict balance of growth factors. Epithelial-to-mesenchymal transition (EMT) is a program whereby injured epithelial cells that function as ion and fluid transporters become matrix remo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e31aaa28084da9dc4bdec544a4cb43b5
https://doi.org/10.1159/000094963
https://doi.org/10.1159/000094963
Autor:
Nadia Abdel Wahab, Mark E. C. Dockrell, Mysore K Phanish, Paul Colville-Nash, Bruce M. Hendry
Publikováno v:
Biochemical Journal. 393:601-607
In chronic renal diseases, progressive loss of renal function correlates with advancing tubulo-interstitial fibrosis. TGFbeta1-Smad (transforming growth factor-beta1-Sma and Mad protein) signalling plays an important role in the development of renal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6a27f409de52cac2da8cf3ee7b5d091
https://doi.org/10.1042/bj20051106
https://doi.org/10.1042/bj20051106
Autor:
O. Yiannikouris, Roger M. Mason, Andrea Babelova, Nadia Abdel Wahab, A. Wright, Benjamin S. Weston, Roland M. Schaefer, Liliana Schaefer
Publikováno v:
Diabetologia. 48:2650-2660
We quantified the glomerular expression of thrombospondin-1 (THBS1, also known as TSP-1), transforming growth factor beta 1 (TGFB1, also known as TGF-beta1) and connective tissue growth factor (CTGF) at each stage of diabetic nephropathy. We also exa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634b0b52b3ab21053755c4d13088ab09
https://doi.org/10.1007/s00125-005-0006-5
https://doi.org/10.1007/s00125-005-0006-5
Autor:
Roger M. Mason, Nadia Abdel Wahab
Publikováno v:
Current Opinion in Nephrology and Hypertension. 13:53-58
Connective tissue growth factor (CCN2) has recently received much attention as a possible key determinant of progressive renal fibrosis. However, the mechanism(s) by which this growth factor functions is not known. The purpose of this review is to su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6c02e019a444d1e980af8f4a0476940
https://doi.org/10.1097/00041552-200401000-00008
https://doi.org/10.1097/00041552-200401000-00008
Publikováno v:
Journal of the American Society of Nephrology. 14:601-610
Excessive deposition of fibronectin in the glomerular mesangium in diabetic nephropathy (DN) is partly due to the induction of transforming growth factor-beta (TGF-beta) by high glucose. TGF-beta induces its downstream mediator connective tissue grow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bad98d63110dd74d587777f6e8beb1f0
https://doi.org/10.1097/01.asn.0000051600.53134.b9
https://doi.org/10.1097/01.asn.0000051600.53134.b9
Publikováno v:
Journal of the American Society of Nephrology. 13:2437-2445
Connective tissue growth factor (CTGF) is now considered to be one of the important driver molecules for the pathogenesis of diabetic nephropathy (DN) and possibly many other fibrotic disorders. However, the molecular mechanisms by which CTGF functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5889740152c5c28bb31555a1d2615cf5
https://doi.org/10.1097/01.asn.0000031828.58276.02
https://doi.org/10.1097/01.asn.0000031828.58276.02
Publikováno v:
Kidney International. 60(5):1756-1764
Bacitracin inhibits fibronectin matrix assembly by mesangial cells in high glucose. Background Accumulation of mesangial extracellular matrix is a major characteristic of diabetic nephropathy (DN). Expression of several extracellular matrix proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e48216c15250158ac9f143464d6e228
Autor:
Nadia Abdel WAHAB, Natalia YEVDOKIMOVA, Benjamin S. WESTON, Terry ROBERTS, Xin Jun LI, Heike BRINKMAN, Roger M. MASON
Publikováno v:
Biochemical Journal. 359:77-87
We characterized a rabbit polyclonal antibody raised against human recombinant connective tissue growth factor (CTGF). The antibody recognised a higher molecular mass form (approx. 56kDa) of CTGF in mesangial cell lysates as well as the monomeric (36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66771dad0130d18552b359e4bc1be367
https://doi.org/10.1042/bj3590077
https://doi.org/10.1042/bj3590077